Na_v1.1 Localizes to Axons of Parvalbumin-Positive Inhibitory Interneurons: A Circuit Basis for Epileptic Seizures in Mice Carrying anScn1aGene Mutation

Critical period plasticity in local cortical circuits

2005 • 2,144 citations

From Ionic Currents to Molecular Mechanisms

2000 • 2,039 citations

Brain-state- and cell-type-specific firing of hippocampal interneurons in vivo

2003 • 1,312 citations

Green fluorescent protein expression and colocalization with calretinin, parvalbumin, and somatostatin in the GAD67‐GFP knock‐in mouse

2003 • 1,239 citations

De Novo Mutations in the Sodium-Channel Gene SCN1A Cause Severe Myoclonic Epilepsy of Infancy

2001 • 1,220 citations

Monoclonal antibodies distinguish phosphorylated and nonphosphorylated forms of neurofilaments in situ.

1983 • 1,162 citations

Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy

2006 • 1,089 citations

Mutations of SCN1A, encoding a neuronal sodium channel, in two families with GEFS+2

2000 • 986 citations

A network of fast-spiking cells in the neocortex connected by electrical synapses

1999 • 969 citations

Salient features of synaptic organisation in the cerebral cortex1Published on the World Wide Web on 3 March 1998.1

1998 • 891 citations

A Perfect Message

1999 • 807 citations

Kv3 channels: voltage-gated K+ channels designed for high-frequency repetitive firing

2001 • 764 citations

Sodium channel Na _v 1.6 is localized at nodes of Ranvier, dendrites, and synapses

2000 • 626 citations

Synchronous Activity of Inhibitory Networks in Neocortex Requires Electrical Synapses Containing Connexin36

2001 • 579 citations

A Common Ankyrin-G-Based Mechanism Retains KCNQ and Na_VChannels at Electrically Active Domains of the Axon

2006 • 554 citations

Sodium channel mutations in epilepsy and other neurological disorders

2005 • 503 citations

Differential subcellular localization of the RI and RII Na+ channel subtypes in central neurons

1989 • 467 citations

Parvalbumin, somatostatin and cholecystokinin as chemical markers for specific GABAergic interneuron types in the rat frontal cortex.

2002 • 391 citations

Molecular Basis of an Inherited Epilepsy

2002 • 369 citations

Inherited disorders of voltage-gated sodium channels

2005 • 367 citations

Differential regulation of three sodium channel messenger RNAs in the rat central nervous system during development.

1989 • 356 citations

Mutations of sodium channel alpha subunit type 1 (SCN1A) in intractable childhood epilepsies with frequent generalized tonic-clonic seizures

2003 • 353 citations

SCN1Amutations and epilepsy

2005 • 351 citations

Shunting Inhibition Improves Robustness of Gamma Oscillations in Hippocampal Interneuron Networks by Homogenizing Firing Rates

2006 • 348 citations

A Targeting Motif Involved in Sodium Channel Clustering at the Axonal Initial Segment

2003 • 344 citations

β Subunits of Voltage-gated Sodium Channels Are Novel Substrates of β-Site Amyloid Precursor Protein-cleaving Enzyme (BACE1) and γ-Secretase

2005 • 288 citations

βIV-spectrin regulates sodium channel clustering through ankyrin-G at axon initial segments and nodes of Ranvier

2002 • 272 citations

βiv Spectrin, a New Spectrin Localized at Axon Initial Segments and Nodes of Ranvier in the Central and Peripheral Nervous System

2000 • 260 citations

Spectrum ofSCN1Amutations in severe myoclonic epilepsy of infancy

2003 • 257 citations

Reduced Sodium Current in Purkinje Neurons from Na_V1.1 Mutant Mice: Implications for Ataxia in Severe Myoclonic Epilepsy in Infancy

2007 • 249 citations

Frequent mutations of SCN1A in severe myoclonic epilepsy in infancy

2002 • 243 citations

Identification of a Conserved Ankyrin-binding Motif in the Family of Sodium Channel α Subunits

2003 • 235 citations

Functional Properties of Electrical Synapses Between Inhibitory Interneurons of Neocortical Layer 4

2004 • 235 citations

Epilepsy-Associated Dysfunction in the Voltage-Gated Neuronal Sodium Channel SCN1A

2003 • 214 citations

Polarized distribution of ion channels within microdomains of the axon initial segment

2006 • 212 citations

Critical Period Mechanisms in Developing Visual Cortex

2005 • 208 citations

Type I and type II Na+ channel ?-subunit polypeptides exhibit distinct spatial and temporal patterning, and association with auxiliary subunits in rat brain

1999 • 207 citations

Enhancement of Spike-Timing Precision by Autaptic Transmission in Neocortical Inhibitory Interneurons

2006 • 204 citations

Mutations of Neuronal Voltage‐gated Na⁺ Channel α1 Subunit Gene SCN1A in Core Severe Myoclonic Epilepsy in Infancy (SMEI) and in Borderline SMEI (SMEB)

2004 • 194 citations

A Nonsense Mutation of the Sodium Channel GeneSCN2Ain a Patient with Intractable Epilepsy and Mental Decline

2004 • 192 citations

Noninactivating voltage-gated sodium channels in severe myoclonic epilepsy of infancy

2004 • 183 citations

Voltage-gated ion channels in the axon initial segment of human cortical pyramidal cells and their relationship with chandelier cells

2006 • 180 citations

Impaired Fast-Spiking, Suppressed Cortical Inhibition, and Increased Susceptibility to Seizures in Mice Lacking Kv3.2 K⁺Channel Proteins

2000 • 179 citations

Tissue-specific expression of the RI and RII sodium channel subtypes.

1987 • 171 citations

Comparative distribution of voltage-gated sodium channel proteins in human brain

2001 • 158 citations

Impaired Firing and Cell-Specific Compensation in Neurons Lacking Na_v1.6 Sodium Channels

2006 • 137 citations

βIVΣ1 spectrin stabilizes the nodes of Ranvier and axon initial segments

2004 • 130 citations

Sodium channel Nav1.6 accumulates at the site of infraorbital nerve injury

2007 • 123 citations

Immunolocalization of sodium channel isoform NaCh6 in the nervous system

2000 • 118 citations

Sodium channel mRNAs I, II and III in the CNS: cell-specific expression

1994 • 111 citations

Monoclonal antibodies SMI 311 and SMI 312 as tools to investigate the maturation of nerve cells and axonal patterns in human fetal brain

1998 • 99 citations

Complications associated with genetic background effects in models of experimental epilepsy

2002 • 96 citations

Nav1.1 channels with mutations of severe myoclonic epilepsy in infancy display attenuated currents

2003 • 82 citations

Nonfunctional SCN1A Is Common in Severe Myoclonic Epilepsy of Infancy

2006 • 78 citations

Sodium channel dysfunction in intractable childhood epilepsy with generalized tonic–clonic seizures

2005 • 73 citations

Distribution of I, II and III subtypes of voltage-sensitive Na+ channel mRNA in the rat brain

1993 • 63 citations

Familial severe myoclonic epilepsy of infancy: truncation of Nav1.1 and genetic heterogeneity.

2003 • 55 citations

Novel clustering of sodium channel Nav1.1 with ankyrin-G and neurofascin at discrete sites in the inner plexiform layer of the retina

2005 • 38 citations

Epilepsy and sodium channel gene mutations: gain or loss of function?

2004 • 32 citations

An analysis of HRP-filled basket cell axons in the cat's cerebellum

1993 • 30 citations

An analysis of HRP-filled basket cell axons in the cat's cerebellum

1993 • 24 citations