Atherosclerosis, vascular amyloidosis and brain hypoperfusion in the pathogenesis of sporadic Alzheimer's disease

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

1993 • 8,888 citations

Prevalence and Trends in Obesity Among US Adults, 1999-2000

2002 • 6,312 citations

Plasma Homocysteine as a Risk Factor for Dementia and Alzheimer's Disease

2002 • 3,174 citations

Increasing prevalence of overweight among US adults. The National Health and Nutrition Examination Surveys, 1960 to 1991

1994 • 2,623 citations

Annual Deaths Attributable to Obesity in the United States

1999 • 1,924 citations

15-year longitudinal study of blood pressure and dementia

1996 • 1,706 citations

Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease

1997 • 1,680 citations

Type 2 Diabetes, APOE Gene, and the Risk for Dementia and Related Pathologies

2002 • 1,166 citations

Cholesterol depletion inhibits the generation of β-amyloid in hippocampal neurons

1998 • 1,139 citations

Simvastatin strongly reduces levels of Alzheimer's disease β-amyloid peptides Aβ42 and Aβ40 in vitro and in vivo

2001 • 1,083 citations

A white matter disorder in dementia of the Alzheimer type: A pathoanatomical study

1986 • 999 citations

Incipient Alzheimer's disease: Microarray correlation analyses reveal major transcriptional and tumor suppressor responses

2004 • 998 citations

Hypercholesterolemia Accelerates the Alzheimer's Amyloid Pathology in a Transgenic Mouse Model

2000 • 984 citations

Midlife blood pressure and dementia: the Honolulu–Asia aging study☆

2000 • 963 citations

The Prevention of Dementia With Antihypertensive Treatment<subtitle>New Evidence From the Systolic Hypertension in Europe (Syst-Eur) Study</subtitle>

2002 • 879 citations

Cardiovascular risk factors and cognitive decline in middle-aged adults

2001 • 876 citations

Dietary fat intake and the risk of incident dementia in the Rotterdam study

1997 • 873 citations

Leuko-Araiosis

1987 • 724 citations

beta-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease.

1993 • 713 citations

Midlife vascular risk factors and late-life mild cognitive impairment

2001 • 699 citations

Early inflammation and dementia: A 25‐year follow‐up of the Honolulu‐Asia aging study

2002 • 679 citations

Diabetes Mellitus and Risk of Alzheimer's Disease and Dementia with Stroke in a Multiethnic Cohort

2001 • 671 citations

Hypertension Is Related to Cognitive Impairment

1998 • 631 citations

Apolipoprotein E ϵ4 Allele, Elevated Midlife Total Cholesterol Level, and High Midlife Systolic Blood Pressure Are Independent Risk Factors for Late-Life Alzheimer Disease

2002 • 630 citations

Induction of Alzheimer-like β-Amyloid Immunoreactivity in the Brains of Rabbits with Dietary Cholesterol

1994 • 549 citations

The Significance of Cerebral White Matter Abnormalities 100 Years After Binswanger’s Report

1995 • 537 citations

The role of cerebral ischemia in Alzheimer’s disease

2000 • 521 citations

A Cholesterol-Lowering Drug Reduces β-Amyloid Pathology in a Transgenic Mouse Model of Alzheimer's Disease

2001 • 516 citations

Preclinical prediction of Alzheimer's disease using SPECT

1998 • 476 citations

Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid β-peptide

2001 • 462 citations

Midlife blood pressure and neuritic plaques, neurofibrillary tangles, and brain weight at death: the HAAS☆

2000 • 447 citations

Cholesterol Modulates α-Secretase Cleavage of Amyloid Precursor Protein

1996 • 444 citations

Frequency of hippocampal formation atrophy in normal aging and Alzheimer's disease

1997 • 422 citations

Assessment of cerebral blood flow in Alzheimer's disease by spin-labeled magnetic resonance imaging

2000 • 405 citations

Development of Alzheimer-related neurofibrillary changes in the neocortex inversely recapitulates cortical myelogenesis

1996 • 390 citations

Cognitive decline in individuals with high blood pressure

1999 • 362 citations

Elevated Low-Density Lipoprotein in Alzheimer's Disease Correlates with Brain Aβ 1–42 Levels

1998 • 305 citations

Deciphering the Genetic Basis of Alzheimer's Disease

2002 • 292 citations

Low Blood Pressure and Risk of Dementia in the Kungsholmen Project

2003 • 281 citations

Circle of Willis Atherosclerosis Is a Risk Factor for Sporadic Alzheimer’s Disease

2003 • 278 citations

Increased Aβ Peptides and Reduced Cholesterol and Myelin Proteins Characterize White Matter Degeneration in Alzheimer's Disease

2002 • 267 citations

Cortical and Leptomeningeal Cerebrovascular Amyloid and White Matter Pathology in Alzheimer’s Disease

2003 • 266 citations

Cortical senile plaques in coronary artery disease, aging and Alzheimer's disease

1990 • 263 citations

Amyloid-β peptide induces oligodendrocyte death by activating the neutral sphingomyelinase–ceramide pathway

2004 • 254 citations

Women, myocardial infarction, and dementia in the very old

1990 • 252 citations

Demonstrating the case that AD is a vascular disease: epidemiologic evidence

2002 • 229 citations

The CERAD Neuropathology Protocol and Consensus Recommendations for the Postmortem Diagnosis of Alzheimer’s Disease: A Commentary

1997 • 226 citations

Increased incidence of neurofibrillary tangles (NFT) in non-demented individuals with hypertension

1995 • 205 citations

Retrogenesis: clinical, physiologic, and pathologic mechanisms in brain aging, Alzheimer’s and other dementing processes

1999 • 191 citations

Clinical Correlates of White-Matter Changes on Magnetic Resonance Imaging Scans of the Brain

1991 • 188 citations

Excess Deaths From Nine Chronic Diseases in the United States, 1986

1990 • 188 citations

Systolic Blood Pressure Tracking Over 25 to 30 Years and Cognitive Performance in Older Adults

1998 • 178 citations

Leuko-Araiosis: An Ancient Term for a New Problem

1986 • 177 citations

A study of regional cerebral blood flow and cognitive performance in Alzheimer's disease.

1992 • 173 citations

Age-Dependent Association of Apolipoprotein E Genotype With Coronary and Aortic Atherosclerosis in Middle-Aged Men

1999 • 169 citations

Cerebral Perfusion Imaging in Alzheimer's Disease

1987 • 168 citations

Cholesterol Accumulates in Senile plaques of Alzheimer Disease patients and in Transgenic APP_swMice

2001 • 167 citations

Variability in Midlife Systolic Blood Pressure Is Related to Late-Life Brain White Matter Lesions

2002 • 163 citations

Secretory processing of amyloid precursor protein is inhibited by increase in cellular cholesterol content

1997 • 152 citations

Leukoaraiosis: correlation of MR and CT findings with blood flow, atrophy, and cognition.

1990 • 143 citations

The Neuropathological Diagnosis of Alzheimer’s Disease: Clinical-Pathological Studies

1997 • 139 citations

Neuropathologic Correlates of Leuko-araiosis

1989 • 138 citations

Clinical features, pathogenesis, and computed tomographic characteristics of internal watershed infarction.

1993 • 135 citations

Joint Effect of the APOE Gene and Midlife Systolic Blood Pressure on Late-Life Cognitive Impairment

2001 • 130 citations

Dynamic susceptibility contrast MR imaging of regional cerebral blood volume in Alzheimer disease: A promising alternative to nuclear medicine

1998 • 128 citations

Association of Aortic Atherosclerosis with Cerebral β-Amyloidosis and Learning Deficits in a Mouse Model of Alzheimer's Disease

2003 • 125 citations

Cholesterol and neuropathologic markers of AD

2001 • 124 citations

Cerebral perfusion as a diagnostic marker of early Alzheimer's disease

1988 • 117 citations

Cerebrovascular Hypoperfusion: A Risk Factor for Alzheimer's Disease?

1997 • 108 citations

Heterogeneity of neocortical cerebral blood flow deficits in dementia of the Alzheimer type: a [99mTc]-d,l-HMPAO SPECT study.

1994 • 106 citations

β-Amyloid from Alzheimer disease brains inhibits sprouting and survival of sympathetic neurons

1991 • 103 citations

Functional MR in the evaluation of dementia: correlation of abnormal dynamic cerebral blood volume measurements with changes in cerebral metabolism on positron emission tomography with fludeoxyglucose F 18.

1995 • 102 citations

The Effect of Brain Atrophy on Cerebral Hypometabolism in the Visual Variant of Alzheimer Disease

2001 • 88 citations

Cerebral Hypoperfusion, Capillary Degeneration, and Development of Alzheimer Disease

2000 • 88 citations

Cognitive Impairment and Cellular/Vascular Changes in the Cerebral White Matter^a

1997 • 86 citations

Impaired Cerebromicrovascular Perfusion: Summary of Evidence in Support of Its Causality in Alzheimer's Disease

2000 • 86 citations

Clinical features, pathogenesis, and computed tomographic characteristics of internal watershed infarction.

1993 • 86 citations

Critically Attained Threshold of Cerebral Hypoperfusion: Can It Cause Alzheimer's Disease?

2000 • 83 citations

Hypertension and Hypercholesterolaemia as Risk Factors for Alzheimer??s Disease

2002 • 83 citations

Improved Recognition of Leukoaraiosis and Cognitive Impairment in Alzheimer's Disease

1991 • 80 citations

Can PET Data Differentiate Alzheimer's Disease from Vascular Dementia?

2000 • 77 citations

Amyloid and lipids in the pathology of Alzheimer disease

1999 • 62 citations

Beta-protein immunoreactivity in the human brain after cardiac arrest.

1996 • 61 citations

Cerebrovascular risk factors in Alzheimer's disease: Brain hemodynamics and pharmacogenomic implications

2003 • 61 citations

Hypertension and Related Factors in the Etiology of Alzheimer's Disease

2002 • 55 citations

Cognitive declines correlate with decreased cortical volume and perfusion in dementia of Alzheimer type

1994 • 46 citations

Severe cardiovascular disease and Alzheimer's disease: Senile plaque formation in cortical areas

1996 • 45 citations

Correlations of leuko-araiosis with cerebral atrophy and perfusion in elderly normal subjects and demented patients.

1993 • 44 citations

Hemodynamic Aspects of Alzheimer's Disease

2002 • 37 citations

Leukb-Araiosis and Cerebral Hypoperfusion Compared in Elderly Normals and Alzheimer's Dementia

1992 • 32 citations

Excess deaths from nine chronic diseases in the United States, 1986

1990 • 30 citations

Treatment of Alzheimer's Disease by Transposition of the Omentum

2002 • 28 citations

Omental Transposition to the Brain for Alzheimer's Disease

1997 • 18 citations

Leuko-Araiosis: Definition and Clinical Correlates – An Overview

1989 • 10 citations

Clinico-pathological Evaluation of Leukoaraisosis in Alzheimer's Disease.

1996 • 5 citations

Neuroimaging, cognitive, and pathological changes in dementia of the Alzheimer type (DAT)

1989 • 5 citations