Intermittent Hypoxia Is Associated with Oxidative Stress and Spatial Learning Deficits in the Rat

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

1991 • 6,550 citations

Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans.

1992 • 5,156 citations

Glutamate and the pathophysiology of hypoxic–ischemic brain damage

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Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

2002 • 1,612 citations

Aging, energy, and oxidative stress in neurodegenerative diseases

1995 • 1,453 citations

The release and uptake of excitatory amino acids

1990 • 1,090 citations

Obstructive sleep apnea and the prefrontal cortex: towards a comprehensive model linking nocturnal upper airway obstruction to daytime cognitive and behavioral deficits

2002 • 877 citations

A Role for 4‐Hydroxynonenal, an Aldehydic Product of Lipid Peroxidation, in Disruption of Ion Homeostasis and Neuronal Death Induced by Amyloid β‐Peptide

1997 • 779 citations

RNA Oxidation Is a Prominent Feature of Vulnerable Neurons in Alzheimer’s Disease

1999 • 718 citations

Ischemia-induced neuronal apoptosis

1996 • 600 citations

Molecular biology of glutamate receptors in the central nervous system and their role in excitotoxicity, oxidative stress and aging

1998 • 575 citations

Alternative excitotoxic hypotheses

1992 • 572 citations

Behavioral and Anatomical Correlates of Chronic Episodic Hypoxia during Sleep in the Rat

2001 • 544 citations

Brain Morphology Associated with Obstructive Sleep Apnea

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Molecular mechanisms of calcium-dependent excitotoxicity

2000 • 467 citations

The Role of Glutamate in Neurotransmission and in Neurologic Disease

1986 • 294 citations

Impaired Spatial Learning and Hyperactivity in Developing Rats Exposed to Intermittent Hypoxia

2002 • 226 citations

RECOGNITION AND CONSEQUENCES OF OBSTRUCTIVE SLEEP APNEA HYPOPNEA SYNDROME

1998 • 187 citations

Signatures of hippocampal oxidative stress in aged spatial learning-impaired rodents

2001 • 178 citations

Relation of Measures of Sleep-Disordered Breathing to Neuropsychological Functioning

2001 • 168 citations

Developmental differences in cortical and hippocampal vulnerability to intermittent hypoxia in the rat

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Coupling Among Energy Failure, Loss of Ion Homeostasis, and Phospholipase A₂ and C Activation During Ischemia

1993 • 119 citations

Proteomic analysis of CA1 and CA3 regions of rat hippocampus and differential susceptibility to intermittent hypoxia

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NMDA and Non‐NMDA Receptor Gene Expression Following Global Brain Ischemia in Rats: Effect of NMDA and Non‐NMDA Receptor Antagonists

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Obstructive sleep apnea

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Sub-regional hippocampal vulnerability in various animal models leading to cognitive dysfunction

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NMDA receptor activation: critical role in oxidant tissue injury

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Pyrrolopyrimidines: novel brain-penetrating antioxidants with neuroprotective activity in brain injury and ischemia models.

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Hypoxia, excitotoxicity, and neuroprotection in the hippocampal slice preparation

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Morbidity of Obstructive Sleep Apnea in Children: Facts and Theory

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Hippocampal Neurons Become More Vulnerable to Glutamate after Subcritical Hypoxia: An in vitro Study

1990 • 54 citations

Morbidity of Obstructive Sleep Apnea in Children: Facts and Theory

2001 • 54 citations

Combination Therapy with MK-801 and α-Phenyl-tert-butyl-nitrone Enhances Protection against Ischemic Neuronal Damage in Organotypic Hippocampal Slice Cultures

1996 • 51 citations

Selective and biphasic effect of the membrane lipid peroxidation product 4‐hydroxy‐2,3‐nonenal on N‐methyl‐<scp>d</scp>‐aspartate channels

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Chronic hypoxia induces modification of the N-methyl-d-aspartate receptor in rat brain

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Superior Neuroprotective Efficacy of a Novel Antioxidant (U-101033E) With Improved Blood-Brain Barrier Permeability in Focal Cerebral Ischemia

1997 • 36 citations

Neuroprotective Efficacy and Mechanisms of Novel Pyrrolopyrimidine Lipid Peroxidation Inhibitors in the Gerbil Forebrain Ischemia Model

1998 • 28 citations

The spin trapping agent PBN stimulates H2O2-induced Erk and Src kinase activity in human neuroblastoma cells

2002 • 20 citations

Mechanisms of hippocampal reoxygenation injury

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Posthypoxic Reoxygenation-Induced Neurotoxicity Prevented by Free Radical Scavenger and NMDA/non-NMDA Antagonist in Tandem as Revealed by Dynamic Changes in Glucose Metabolism with Positron Autoradiography

2000 • 10 citations