Cyp26 enzymes generate the retinoic acid response pattern necessary for hindbrain development

Stages of embryonic development of the zebrafish

1995 • 11,263 citations

Embryonic retinoic acid synthesis is essential for early mouse post-implantation development

1999 • 1,051 citations

Nuclear retinoid receptors and the transcription of retinoid-target genes

2004 • 739 citations

Expression of a retinoic acid response element-hsplacZ transgene defines specific domains of transcriptional activity during mouse embryogenesis.

1991 • 730 citations

The retinoic acid-metabolizing enzyme, CYP26A1, is essential for normal hindbrain patterning, vertebral identity, and development of posterior structures

2001 • 550 citations

Sequential activation of HOX2 homeobox genes by retinoic acid in human embryonal carcinoma cells

1990 • 524 citations

dead end, a Novel Vertebrate Germ Plasm Component, Is Required for Zebrafish Primordial Germ Cell Migration and Survival

2003 • 450 citations

A conserved retinoic acid response element required for early expression of the homeobox gene Hoxb-1

1994 • 446 citations

The retinoic acid-inactivating enzyme CYP26 is essential for establishing an uneven distribution of retinoic acid along the anterio-posterior axis within the mouse embryo

2001 • 439 citations

Retinoic acid synthesis and hindbrain patterning in the mouse embryo

2000 • 377 citations

Identification of the Retinoic Acid-inducible All-trans-retinoic Acid 4-Hydroxylase

1996 • 376 citations

The zebrafish gene map defines ancestral vertebrate chromosomes

2005 • 371 citations

The zebrafishnecklessmutation reveals a requirement forraldh2in mesodermal signals that pattern the hindbrain

2001 • 366 citations

Metabolic inactivation of retinoic acid by a novel P450 differentially expressed in developing mouse embryos

1997 • 362 citations

The cellular basis of segmentation in the developing hindbrain

1990 • 358 citations

Vitamin A-deficient quail embryos have half a hindbrain and other neural defects

1996 • 335 citations

Regulation of Retinoic Acid Distribution Is Required for Proximodistal Patterning and Outgrowth of the Developing Mouse Limb

2004 • 315 citations

Retinoic acid signalling in the zebrafish embryo is necessary during pre-segmentation stages to pattern the anterior-posterior axis of the CNS and to induce a pectoral fin bud

2002 • 298 citations

Distinct roles for Fgf, Wnt and retinoic acid in posteriorizing the neural ectoderm

2002 • 288 citations

The retinoid ligand 4-oxo-retinoic acid is a highly active modulator of positional specification

1993 • 285 citations

Role of a Conserved Retinoic Acid Response Element in Rhombomere Restriction of Hoxb-1

1994 • 281 citations

Complementary Domains of Retinoic Acid Production and Degradation in the Early Chick Embryo

1999 • 279 citations

Zebrafish hox genes: expression in the hindbrain region of wild-type and mutants of the segmentation gene, valentino

1998 • 276 citations

Initiation of Rhombomeric Hoxb4 Expression Requires Induction by Somites and a Retinoid Pathway

1998 • 275 citations

Retinoic acid signalling links left–right asymmetric patterning and bilaterally symmetric somitogenesis in the zebrafish embryo

2005 • 269 citations

Novel retinoic acid generating activities in the neural tube and heart identified by conditional rescue ofRaldh2null mutant mice

2002 • 251 citations

Genetic evidence that oxidative derivatives of retinoic acid are not involved in retinoid signaling during mouse development

2002 • 231 citations

Constructing the hindbrain: Insights from the zebrafish

2002 • 222 citations

Cloning of a novel retinoic-acid metabolizing cytochrome P450, Cyp26B1, and comparative expression analysis with Cyp26A1 during early murine development

2001 • 217 citations

Hindbrain patterning involves graded responses to retinoic acid signalling

2001 • 214 citations

A Novel Human Cytochrome P450, CYP26C1, Involved in Metabolism of 9-cis and All-trans Isomers of Retinoic Acid

2003 • 212 citations

Cytochrome P450RAI(CYP26) Promoter: A Distinct Composite Retinoic Acid Response Element Underlies the Complex Regulation of Retinoic Acid Metabolism

2000 • 209 citations

Nuclear re-organisation of theHoxbcomplex during mouse embryonic development

2005 • 197 citations

Differential expression of the retinoic acid-metabolizing enzymes CYP26A1 and CYP26B1 during murine organogenesis

2002 • 189 citations

Equivalence in the genetic control of hindbrain segmentation in fish and mouse

1998 • 184 citations

Activation of Retinoic Acid Receptor-dependent Transcription by All-trans-retinoic Acid Metabolites and Isomers

2002 • 168 citations

Shifting boundaries of retinoic acid activity control hindbrain segmental gene expression

2005 • 166 citations

Zebrafish Meis functions to stabilize Pbx proteins and regulate hindbrain patterning

2001 • 159 citations

Cyp26C1 encodes a novel retinoic acid-metabolizing enzyme expressed in the hindbrain, inner ear, first branchial arch and tooth buds during murine development

2003 • 147 citations

Retinoic acid metabolism blocking agents (RAMBAs) for treatment of cancer and dermatological diseases

2006 • 144 citations

Feedback mechanisms regulate retinoic acid production and degradation in the zebrafish embryo

2004 • 141 citations

CYP26A1 and CYP26C1 cooperatively regulate anterior–posterior patterning of the developing brain and the production of migratory cranial neural crest cells in the mouse

2006 • 138 citations

Provitamin A conversion to retinal via theβ,β-carotene-15,15′-oxygenase (bcox) is essential for pattern formation and differentiation during zebrafish embryogenesis

2003 • 137 citations

The control of morphogen signalling: Regulation of the synthesis and catabolism of retinoic acid in the developing embryo

2005 • 134 citations

Active repression of RAR signaling is required for head formation

2001 • 127 citations

Retinoic acid-metabolizing enzyme Cyp26a1 is essential for determining territories of hindbrain and spinal cord in zebrafish

2004 • 126 citations

Dynamic and sequential patterning of the zebrafish posterior hindbrain by retinoic acid

2005 • 123 citations

TGIF Inhibits Retinoid Signaling

2006 • 116 citations

vhnf1integrates global RA patterning and local FGF signals to direct posterior hindbrain development in zebrafish

2004 • 111 citations

Hindbrain respecification in the retinoid-deficient quail

1999 • 111 citations

Endogenous retinoids in the zebrafish embryo and adult

1996 • 107 citations

R115866 inhibits all-trans-retinoic acid metabolism and exerts retinoidal effects in rodents.

2000 • 107 citations

Generating gradients of retinoic acid in the chick embryo: Cyp26C1 expression and a comparative analysis of the Cyp26 enzymes

2004 • 101 citations

Inhibition of mouse cytosolic aldehyde dehydrogenase by 4-(diethylamino)benzaldehyde

1988 • 96 citations

Beyond the neckless phenotype: influence of reduced retinoic acid signaling on motor neuron development in the zebrafish hindbrain

2004 • 95 citations

ArRAnging the hindbrain

2002 • 78 citations

Marrying Planning, Economics and Environment: Is South Africa ahead of the curve?

2000 • 70 citations

Characterization of the retinoic acid receptor genes raraa, rarab and rarg during zebrafish development

2006 • 63 citations

Murine Hoxd4 expression in the CNS requires multiple elements including a retinoic acid response element

2000 • 60 citations

The role of a retinoic acid response element in establishing the anterior neural expression border of Hoxd4 transgenes

2003 • 58 citations

Expression of cyp26b1 during zebrafish early development

2004 • 57 citations

Molecular cloning and expression of a novel CYP26 gene (cyp26d1) during zebrafish early development

2005 • 57 citations

A Second CYP26 P450 in Humans and Zebrafish: CYP26B1

1999 • 57 citations

Cytochrome P450 Retinoic Acid 4-Hydroxylase Inhibitors: Potential Agents for Cancer Therapy

2002 • 56 citations

The zebrafish Iroquois geneiro7positions the r4/r5 boundary and controls neurogenesis in the rostral hindbrain

2004 • 52 citations

Characterization of retinoid-X receptor genes rxra, rxrba, rxrbb and rxrg during zebrafish development

2006 • 52 citations