Analysis of immunodeficiency in multiple myeloma: Observations and hypothesis

Induction of immunological paralysis in two zones of dosage

1964 • 439 citations

Impaired Synthesis of Polyclonal (Non-Paraprotein) Immunoglobulins by Circulating Lymphocytes from Patients with Multiple Myeloma

1975 • 430 citations

A monoclonal antibody (BA-1) reactive with cells of human B lymphocyte lineage.

1981 • 400 citations

Direct demonstration of the clonogenic potential of every human peripheral blood T cell. Clonal analysis of HLA-DR expression and cytolytic activity.

1983 • 351 citations

Myeloma Proteins as Tumor-Specific Transplantation Antigens

1972 • 325 citations

Studies on the clonal origin of multiple myeloma. Use of individually specific (idiotype) antibodies to trace the oncogenic event to its earliest point of expression in B-cell differentiation.

1979 • 255 citations

Infection, antibody response and gamma globulin components in multiple myeloma and macroglobulinemia

1963 • 230 citations

Differences in susceptibility of mature and immature mouse B lymphocytes to anti-immunoglobulin-induced immunoglobulin suppression in vitro. Possible implications for B-cell tolerance to self.

1975 • 228 citations

Studies of surface immunoglobulins on human B lymphocytes. I. Dissociation of cell-bound immunoglobulins with acid pH or at 37 degrees C.

1975 • 226 citations

Immunological Deficiency Disorders Associated with Chronic Lymphocytic Leukemia and Multiple Myeloma*

1964 • 218 citations

Receptor-mediated inactivation of early B lymphocytes

1975 • 187 citations

Monoclonal lymphocyte population in human plasma cell myeloma.

1974 • 173 citations

Extraskeletal spread in multiple plasma cell myeloma:A review of 57 autopsied cases

1969 • 168 citations

RECURRENT PNEUMONIA IN MULTIPLE MYELOMA AND SOME OBSERVATIONS ON IMMUNOLOGIC RESPONSE

1954 • 158 citations

'Benign' Monoclonal Gammopathy

1984 • 151 citations

Multiple Myeloma and Benign Monoclonal Gammopathy: Differentiation by Immunofluorescence of Lymphocytes

1973 • 142 citations

Abnormal monoclonal antibody‐defined helper/suppressor T‐cell subpopulations in multiple myeloma: relationship to treatment and clinical stage

1983 • 131 citations

Idiotype-like molecules on cells of a human T cell leukemia.

1983 • 126 citations

Thirty cases of monoclonal immunoglobulin disorders other than myeloma or macroglobulinemia

1969 • 125 citations

Extraosseous lesions in plasma cell myeloma

1967 • 125 citations

Induction of antiphosphorylcholine antibody formation by anti-idiotypic antibodies.

1975 • 119 citations

Limiting dilution analysis of Epstein-Barr virus-induced immunoglobulin production by human B cells.

1983 • 117 citations

On the control between cell-mediated, IgM and IgG immunity

1974 • 111 citations

The Monoclonal Nature of Lymphocytes in Multiple Myeloma

1975 • 107 citations

Multiple Myeloma: Lesions of the Extra-osseous Hematopoietic System

1950 • 105 citations

Multiple myeloma: circulating lymphocytes that express plasma cell antigens

1984 • 98 citations

Neonatal Tolerance Induced by Antibody against Antigen-Specific Receptor

1974 • 97 citations

Idiotype‐bearing and antigen‐binding receptors produced by blood T lymphocytes in a case of human myeloma

1977 • 96 citations

Studies on the Pathogenesis of an Immune Defect in Multiple Myeloma

1977 • 92 citations

T Cells in Monoclonal Gammopathies

1982 • 91 citations

Neoplastic Diseases of the Blood

1985 • 91 citations

Prognostic relevance of cellular morphology in multiple myeloma

1984 • 88 citations

Occurrence and Potential Significance of Increased Numbers of T Cells with Fc Receptors in Myeloma¹

1981 • 81 citations

Multiple Myeloma, Waldenström's Macroglobulinemia, and Benign Monoclonal Gammopathy: Characteristics of The B Cell Clone, Immunoregulatory Cell Populations and Clinical Implications

1984 • 75 citations

Characteristics of Epstein-Barr virus activation of human B lymphocytes.

1981 • 72 citations

Self-Tolerance and Autoimmunity in the Thyroid

1976 • 71 citations

Idiotypic Immunoglobulin Structures on Blood Lymphocytes in Human Plasma Cell Myeloma

1977 • 71 citations

Immunodeficiency and the pathogenesis of non-Hodgkin's lymphoma.

1980 • 67 citations

Suppression of polyclonal immunoglobulins in multiple myeloma: Relationship to the staging and other manifestations at diagnosis

1980 • 66 citations

Ability of CBA Mice to produce Anti-idiotypic Sera to 5563 Myeloma Protein

1970 • 66 citations

Idiotypic peripheral blood lymphocytes in monoclonal gammopathy.

1982 • 64 citations

Changes in Lymphocyte Surface Immunoglobulins in Myeloma and the Effect of an RNA-Containing Plasma Factor

1975 • 63 citations

Shared Idiotypes on Human Peripheral Blood B and T Lymphocytes

1979 • 63 citations

Production of Antibodies against Viruses in Leukaemia and Related Diseases

1964 • 62 citations

Severe deficiency of B lymphocytes in peripheral blood from multiple myeloma patients.

1984 • 61 citations

Pre-B cells in peripheral blood of multiple myeloma patients

1985 • 59 citations

Unusual pattern of surface marker expression on peripheral lymphocytes from aged humans suggestive of a population of less differentiated cells.

1983 • 57 citations

Survival and function of bursa-derived cells in bursectomized chickens

1973 • 55 citations

Hypothesis: A model for generalised autoimmunity

1973 • 54 citations

Humoral immune deficiency in multiple myeloma patients due to compromised B-cell function

1986 • 53 citations

The Control of Humoral and Associative Antibody Synthesis

1972 • 49 citations

Immunoregulatory Circuits in Myeloma

1982 • 48 citations

Clonal Depletion in Neonatal Tolerance

1974 • 45 citations

Regulation of pre‐B cell proliferation in bone marrow: immunofluorescence stathmokinetic studies of cytoplasmic p chain‐bearing cells in anti‐IgM‐treated mice, hematologically deficient mutant mice and mice given sheep red blood cells

1985 • 44 citations

Regulation of human B lymphopoiesis: effect of a urinary activity associated with cyclic neutropenia.

1985 • 43 citations

Limiting dilution analysis of cells of the immune system II: What can be learnt?

1984 • 42 citations

Ontogeny of mouse B lymphocytes and inactivation by antigen of early B lymphocytes.

1976 • 41 citations

Membrane phenotype and functional behaviour of T lymphocytes in multiple myeloma: correlation with clinical stages of the disease.

1984 • 41 citations

Lymphocyte surface membrane immunoglobulin in myeloma. III. IgA plasmacytomas induce large numbers of circulating, adult-thymectomy-sensitive, theta +, Lyt-1-2+ lymphocytes with IgA-Fc receptors.

1982 • 38 citations

Changing Patterns of Infections in Patients with Multiple Myeloma

1982 • 38 citations

Defective binding of the third component of complement (C3) to Streptococcus pneumoniae in multiple myeloma

1984 • 37 citations

Monoclonal Blood Lymphocytes in Benign Monoclonal Gammopathy and Multiple Myeloma in Relation to Clinical Stage

1981 • 36 citations

Kinetics of circulating B lymphocytes in human myeloma

1983 • 36 citations

Idiotype-bearing Peripheral Blood Lymphocytes in Human Multiple Myeloma and Waldenstrom's Macroglobulinaemia

1980 • 34 citations

Pre-B cells in mouse bone marrow: in vitro maturation of peanut agglutinin binding B lymphocyte precursors separated from bone marrow by fluorescence-activated cell sorting.

1984 • 33 citations

The idiotypic specificities of lymphocytes in human monoclonal gammopathies: analysis with the fluorescence activated cell sorter.

1983 • 31 citations

Idiotypic lymphocytes in human monoclonal gammopathies

1981 • 31 citations

Abnormal clonogenic potential of T cells from multiple myeloma patients

1985 • 31 citations

Detection of Monoclonal B Lymphocytes in Multiple Myeloma by Immunofluorescence Tests of Surface Immunoglobulins

1978 • 29 citations

Chronic lymphocytic leukemia progenitor cells carry the antigens T65, BA-1, and Ia

1983 • 29 citations

Idiotypic studies on myeloma B cells

1979 • 29 citations

Abnormal function of B lymphocytes from peripheral blood of multiple myeloma patients. Lack of correlation between the number of cells potentially able to secrete immunoglobulin M and serum immunoglobulin M levels.

1985 • 28 citations

Immune function in multiple myeloma: impaired responsiveness to keyhole limpet hemocyanin.

1971 • 28 citations

In vivo kinetic studies in human myeloma.

1974 • 27 citations

A regulatory role for the memory B cell as suppressor-inducer of feedback control.

1983 • 27 citations

Increased T gamma and T mu cells in BALB/c mice with IgG and IgM plasmacytomas and hybridomas.

1986 • 25 citations

Differentiation between benign and malignant monoclonal gammopathy by the presence of the J chain.

1981 • 25 citations

Circulating immunoglobulin-secreting cells in patients with plasma cell dyscrasia

1980 • 25 citations

Construction of an antigenic map for human B-cell precursors

1983 • 25 citations

Anti-tumor immunity in b-lymphocyte-deprived mice. iii. immunity to primary moloney sarcoma virus-induced tumors

1982 • 23 citations

Antibody Response to Pneumococcal Vaccination in Patients with Myelomatosis

1983 • 23 citations

Idiotypic determinants on human T cells and modulation of human T cell responses by anti-idiotypic antibodies.

1984 • 22 citations

Specificity repertoire of lymphocytes from multiple myeloma patients. I. High frequency of B cells specific for idiotypic and F(ab?)2-region determinants on immunoglobulin

1985 • 22 citations

Subpopulations of T-Lymphocytes in Multiple Myeloma

1981 • 22 citations

X-linked B lymphocyte deficiency

1974 • 21 citations

In Vitro Immunoglobulin Production by Peripheral Blood Mononuclear Cells from Multiple Myeloma Patients and Patients with Benign Monoclonal Gammopathy

1984 • 20 citations

In vitro cytotoxic response to human myeloma plasma cells by peripheral blood leukocytes from patients with multiple myeloma and benign monoclonal gammopathy

1979 • 19 citations

Differentiation Between Benign and Malignant Monoclonal Gammopathies by Discriminant Analysis on Serum and Bone Marrow Parameters

1978 • 19 citations

T‐cell subsets in malignant lymphomas and monoclonal gammopathies

1985 • 19 citations

DEVELOPMENT OF A SECOND MONOCLONAL IMMUNOGLOBULIN G IN A PATIENT WITH LATE MANIFESTATION OF MYELOMA

1972 • 16 citations

Distribution of Immunoglobulin‐Containing Cells in Bone Marrow and Lymphoid Tissues in Patients with Monoclonal Gammapathy

1978 • 15 citations

Smoldering Multiple Myeloma

1980 • 12 citations

Pre‐B cells in bone marrow: peanut agglutinin binding and separation of cytoplasmic μ chain‐bearing cell populations in normal, post‐irradiation and polycythemic mice using fluorescence‐activated cell sorting

1984 • 10 citations

Suppression of one monoclonal immunoglobulin in the presence of another in multiple myeloma: Evidence for benign B-cell neoplasia

1983 • 9 citations

Preference of the early murine immune response for polymorphic determinants on human lymphoid-leukemia cells and the potential use of monoclonal antibodies to these determinants in leukemia-typing panel.

1982 • 9 citations

[OKT-8+ suppressor T-lymphocytes are increased in patients with stable multiple myeloma].

1983 • 9 citations

Peripheral Blood Lymphocyte Subpopulations in Multiple Myeloma

1979 • 7 citations

Mediastinal adenopathy in myeloma.

1980 • 4 citations

Bone Marrow and B Cell Differentiation

1982 • 4 citations

The Effect of Anti‐Ia Antibody on Immunoglobulin‐secreting Cells from Healthy Individuals and Myeloma Patients

1982 • 3 citations

Deleted Work

1955 • 0 citations