Chromatography of the 1,4-benzodiazepines

Metabolism of diazepam in rat, dog, and man.

1965 • 229 citations

6-Phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines which have central nervous system depressant activity

1971 • 209 citations

Blood Level Distribution Patterns of Diazepam and its Major Metabolite in Man

1966 • 202 citations

Determination medazepam (Nobrium), diazepam (Valium), and their major biotransformation products in blood and urine by electron capture gas-liquid chromatography

1970 • 158 citations

Determination of Diazepam (Valium) in Blood by Gas Liquid Chromatography.

1964 • 113 citations

Use of Thin Layer Chromatography in the Diagnosis of Poisoning

1963 • 108 citations

Blood Level Profile in Man following Chronic Oral Administration of Flurazepam Hydrochloride

1973 • 103 citations

Determination of bioavailability of diazepam in various formulations from steady state plasma concentration data

1972 • 101 citations

Diazepam metabolism during chronic medication

1973 • 98 citations

Identification of narcotics, barbiturates, amphetamines, tranquilizers and psychotomimetics in human urine

1969 • 95 citations

Characterization of the binding of benzodiazepines to human serum albumin

1973 • 90 citations

Pharmacokinetics of Diazepam in Dogs, Mice and Humans

1971 • 89 citations

Determination of chlordiazepoxide (Librium) and of a metabolite of lactam character in plasma of humans, dogs, and rats by a specific spectrofluorometric micro method

1963 • 87 citations

A GLC Based System for the Detection of Poisons, Drugs, and Human Metabolites Encountered in Forensic Toxicology

1971 • 85 citations

Absorption, Metabolism, and Excretion of Oxazepam and Its Succinate Half-Ester

1964 • 79 citations

THE METABOLIC FATE OF C14-LABELED CHLORDIAZEPOXIDE IN MAN, IN THE DOG, AND IN THE RAT.

1965 • 77 citations

Metabolic N-Demethylation of Chlordiazepoxide

1966 • 76 citations

Determination of Flurazepam and Its Major Biotransformation Products in Blood and Urine by Spectrophotofluorometry and Spectrophotometry

1971 • 75 citations

Serum Concentrations of Diazepam in Subjects With Epilepsy

1973 • 73 citations

Detection of basic organic drugs and their metabolites in urine.

1970 • 70 citations

A method for gas chromatographic determination of benzodiazepines

1968 • 69 citations

Diazepam metabolites in the rat: Characterization by high-resolution mass spectrometry and nuclear magnetic resonance

1967 • 67 citations

The Transfer of Diazepam Across the Placenta During Labour

1973 • 67 citations

Thermolysis of 1,4-Benzodiazepines during Gas Chromatography and Mass Spectroscopy

1971 • 66 citations

Detection of Basic Organic Drugs and Their Metabolites in Urine

1970 • 65 citations

Routine identification of drugs of abuse in human urine

1971 • 65 citations

Metabolism of Flurazepam, a Benzodiazepine, in Man and Dog

1970 • 61 citations

Gas chromatographic degradation of several drugs and their metabolites

1973 • 59 citations

A GC/MS Reference Data System for the Identification of Drugs of Abuse

1972 • 57 citations

The Liquid Chromatography of Some Benzodiazepines

1970 • 54 citations

TLC Techniques for Identification of Narcotics, Barbiturates, and CNS Stimulants in a Drug Abuse Urine Screening Program

1972 • 54 citations

Quantitative determination of diazepam in blood by radioimmunoassay.

1973 • 51 citations

Further studies on species difference in diazepam metabolism

1970 • 49 citations

Metabolism of diazepam in dogs: Transformation to oxazepam

1965 • 49 citations

Metabolism of14C-medazepam hydrochloride in dog, rat and man

1970 • 47 citations

The use of thin-layer chromatography for the analysis of drugs. Identification and isolation of phenothiazine tranquilizers and of antihistaminics in body fluids and tissues.

1963 • 44 citations

An Efficient Packed Column for Free Fatty Acids

1964 • 43 citations

Electron Capture Gas Chromatography of Nitrazepam in Human Plasma as Methyl Derivative

1973 • 43 citations

Determination of chlordiazeporide plasma concentrations by electron capture gas-liquid chromatography

1971 • 42 citations

Gas—liquid chromatography of submicrogram amounts of drugs

1966 • 42 citations

Systematic identification of psychotropic drugs by thin-layer chromatography. Part I

1967 • 41 citations

Quantitative determination of clonazepam and its metabolites in human plasma by gas chromatography

1974 • 41 citations

Determination of nitrazepam (Mogadon) in plasma by electron capture gas-liquid chromatography

1972 • 40 citations

An ultra rapid method for the extraction of drugs from biological fluids

1971 • 38 citations

ASSAY AND PHARMACOKINETICS OF CLONAZEPAM IN HUMANS

2009 • 37 citations

Gas—Liquid chromatography and mass spectrometry of various benzodiazepines

1971 • 36 citations

High Pressure Liquid Chromatography of Benzodiazepines: Analysis of Ketazolam

1972 • 33 citations

Urinary Metabolites of 7-Chloro-1-(2-diethylaminoethyl)-5-(2-flurophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one Dihydrochloride

1968 • 32 citations

Electroreduction and polarographic determination of nitrazepam in serum

1972 • 30 citations

A Specific, Rapid and Sensitive Method for Gas-Chromatographic Determination of Methyloxazepam in Small Samples of Blood

1972 • 29 citations

A comprehensive gas chromatographic scheme for the estimation of antiepileptic drugs

1972 • 29 citations

Benzodiazepine Metabolism in Vitro

1972 • 28 citations

A method for the detection of drugs at therapeutic dosages in human urine using adsorption column chromatography and thin-layer chromatography

1972 • 28 citations

Pharmacokinetic Model for Chlordiazepoxide·HCl in the Dog

1970 • 28 citations

Systematic identification of psychotropic drugs by thin layer chromatography. Part II

1968 • 28 citations

An improved method for rapid, large-scale thin-layer chromatographic urine screening for drugs of abuse

1971 • 27 citations

Polarographische Auswertung von Dünnschicht‐Chromatogrammen

1965 • 27 citations

Chlordiazepoxide metabolites in the rat. Characterization by high resolution mass spectrometry

1968 • 26 citations

Determination of 7-Bromo-1,3-dihydro-5-(2-pyridyl)-2H-1,4-benzodiazepin-2-one (Ro 5-3350) in Blood by Gas–Liquid Chromatography

1966 • 25 citations

Isoelectric focusing of alkaline phosphatases. A focusing-disc electrophoresis transfer technique

1971 • 25 citations

Quantitative Determination of Medazepam, Diazepam, and Nitrazepam in Whole Blood by Flame-Ionization Gas—liquid Chromatography

1974 • 23 citations

Thin-layer chromatography of toxicologically significant substances on silica gel-coated glass plates and polyester sheets

1967 • 23 citations

Direct mass spectrometric analysis of body fluids from acutely poisoned patients

1973 • 22 citations

Metabolism of diazepam in rabbits

1964 • 21 citations

The Determination of 7-chloro-1,3-dihydro-5-(2',chlorophenyl)-2H-1,4-benzodiazepin-2-one (Ro 5-3027) and Its Metabolite (Lorazepam) in Blood and Urine by Electron-Capture Gas Liquid Chromatography

1973 • 21 citations

Determination of Diazepam (Valium) Concentrations in Serum by Gas—Liquid Chromatography

1970 • 21 citations

Metabolites of Demoxepam, a Chlordiazepoxide Metabolite, in Man

1972 • 21 citations

The use of spectrophotofluorometry in the analysis of drugs in biological materials.

1969 • 20 citations

Determination of tranquillizers by GLC in biological fluids

1971 • 20 citations

Intérêt de la chromatographie sur couche mince d'adsorbant pour l'identification en toxicologie d'urgence des benzo[f]diazépines-1,4 utilisées en thérapeutique

1971 • 20 citations

[ON THE PHARMACOLOGY OF MOGADON, A HYPNOTIC WITH AN UNUSUAL ACTION MECHANISM].

1965 • 19 citations

A rapid gas chromatographic method for the determination of diazepam and metabolites in body fluids

1974 • 19 citations

Profile of Sedatives and Tranquilizers in Serum, as Measured by Gas-Liquid Chromatography

1971 • 19 citations

Brain concentrations of lorazepam and oxazepam at equal degree of anticonvulsant activity

1972 • 18 citations

Detection and identification of nitrazepam and related compounds by thin-layer chromatography

1970 • 18 citations

Nitrazepam (Mogadon) in blood serum and urine and librium in urine

1968 • 18 citations

The cathode-ray polarographic determination of diazepam, 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepine-2-one, in human plasma

1971 • 17 citations

Analysis of Blood: A Simplified Gas Chromatographic Approach for Toxicologic Purposes

1968 • 16 citations

A comprehensive scheme for the evaluation of anticonvulsant concentrations in blood using thin-layer chromatography

1971 • 16 citations

Oxazepam Excretion by Chlordiazepoxide-14C-Dosed Dogs

1967 • 15 citations

Metabolism of Demoxepam, a Chlordiazepoxide Metabolite, in the Dog

1971 • 15 citations

Prazepam metabolism in vitro

1972 • 15 citations

BIOTRANSFORMATION OF PRAZEPAM IN MAN

1971 • 14 citations

A gas chromatographie assay for medazepam and its major metabolites in plasma

1973 • 14 citations

Prazepam Metabolites in Dog Urine

1970 • 14 citations

A rapid method for the detection of methaqualone metabolites

1971 • 13 citations

Detection of Some Psychotherapeutic Drugs and Their Metabolites in Urine

1971 • 13 citations

Metabolism of diazepam in rabbits

1964 • 12 citations

Systematic applications of gas-liquid chromatography in toxicology

1967 • 12 citations

Identification of Drugs Taken in Overdose Cases

1972 • 12 citations

An urinary metabolite of bromazepam

1972 • 11 citations

Studies on the Metabolism of Oxazolam. II. Isolation and Identification of the Metabolites of Oxazolam in Rats

1971 • 11 citations

Empfindlicher nachweis von substanzen mit primären aminogruppen auf dünnschichtplatten

1970 • 10 citations

Prazepam Metabolism in the Rat

1973 • 10 citations

[Study of benzo-(f)-diazepine-1,4 derivatives employed in therapeutics. II. Identification and assay by gas-phase chromatography of benzo-(f)-diazepine-1,4 derivatives, their main metabolites and compounds formed by their acid hydrolysis].

1970 • 9 citations

Determination of an indolyl-1,4-benzodiazepine in blood by spectrophotofluorometry

1973 • 9 citations

Rapid Identification of Drugs in Body Fluids of Comatose Patients

1973 • 8 citations

Metabolism of Cloxazolam. I. Distribution, Excretion and Biotransformation in Rats and Mice

1973 • 8 citations

Emergency Drug Analysis

1972 • 8 citations

Der schnellnachweis von lorazepam (Tavor®), einem neuen Tranquilizer aus der Reihe der Benzodiazepine

1973 • 7 citations

Ataraxics and Nonbarbiturate Sedatives

1963 • 6 citations

Detection and separation of five 5-phenyl-1,4-benzodiazepine tranquilizers by thin-layer chromatographical SRS-technique

1972 • 6 citations

Gas chromatographic analysis of medazepam and its metabolites using an electrolytic conductivity detector

1974 • 5 citations

Über die Verwendung von homogenen azeotropen Gemischen in der Dünnschicht-Chromatographie

1969 • 5 citations

Rapid Identification of Psychopharmacologic Agents in Cases of Drug Abuse

1972 • 5 citations

The Chromatographic Separation of Mixtures of Benzodiazepine Drugs

1971 • 5 citations

[Determination of diazepam in blood and urine by gas chromatography. II. Pharmacologic and toxicologic application].

1967 • 4 citations

[Demonstration of drugs and their metabolites in serum and urine using thin-layer chromatography].

1965 • 1 citations