Strategies in prevention of invasive pulmonary aspergillosis in immunosuppressed or neutropenic patients

A Controlled Trial of Fluconazole to Prevent Fungal Infections in Patients Undergoing Bone Marrow Transplantation

1992 • 1,179 citations

Amphotericin B: 30 Years of Clinical Experience

1990 • 1,011 citations

Antifungal and Surgical Treatment of Invasive Aspergillosis: Review of 2,121 Published Cases

1990 • 918 citations

Empiric antibiotic and antifungal therapy for cancer patients with prolonged fever and granulocytopenia

1982 • 875 citations

Prolonged Granulocytopenia: The Major Risk Factor for Invasive Pulmonary Aspergillosis in Patients with Acute Leukemia

1984 • 772 citations

Fluconazole

1990 • 658 citations

Selective Protection against Conidia by Mononuclear and against Mycelia by Polymorphonuclear Phagocytes in Resistance to Aspergillus

1982 • 624 citations

Fungal infections in cancer patients: An international autopsy survey

1992 • 556 citations

Pulmonary Aspergillosis in the Acquired Immunodeficiency Syndrome

1991 • 511 citations

Control of Granulocytes and Macrophages: Molecular, Cellular, and Clinical Aspects

1991 • 377 citations

Fluconazole Prophylaxis of Fungal Infections in Patients with Acute Leukemia: Results of a Randomized Placebo-Controlled, Double-Blind, Multicenter Trial

1993 • 374 citations

Treatment of invasive aspergillosis with itraconazole

1989 • 368 citations

Opportunistic Mycoses in the Immunocompromised Host: Experience at a Cancer Center and Review

1992 • 367 citations

Fungal infections in patients with acute leukemia

1982 • 361 citations

Fungal infection in chronic granulomatous disease

1981 • 361 citations

Impact of air filtration on nosocomial aspergillus infections

1987 • 346 citations

Efficacy of amphotericin B encapsulated in liposomes (AmBisome) in the treatment of invasive fungal infections in immunocompromised patients

1991 • 281 citations

Empirical antifungal therapy in febrile granulocytopenic patients

1989 • 272 citations

Liposomal amphotericin B (AmBisome): safety data from a phase II/III clinical trial

1991 • 236 citations

Invasive Aspergillosis in Renal Transplant Recipients: Correlation with Corticosteroid Therapy

1983 • 235 citations

Fungal infections in bone marrow transplant patients.

1990 • 234 citations

Distribution and Activity of Amphotericin B in Humans

1985 • 228 citations

Hematopoietic growth factors and their receptors in acute leukemia

1993 • 215 citations

Primary Cutaneous Aspergillosis Associated with Hickman Intravenous Catheters

1987 • 214 citations

Nosocomial aspergillosis: Environmental microbiology, hospital epidemiology, diagnosis and treatment

1989 • 213 citations

Activity of Orally, Topically, and Parenterally Administered Itraconazole in the Treatment of Superficial and Deep Mycoses: Animal Models

1987 • 212 citations

Enhancement of oxidative response and damage caused by human neutrophils to Aspergillus fumigatus hyphae by granulocyte colony-stimulating factor and gamma interferon

1993 • 209 citations

Efficacy of Infection Control Measures During a Nosocomial Outbreak of Disseminated Aspergillosis Associated with Hospital Construction

1986 • 199 citations

Adverse events associated with itraconazole in 189 patients on chronic therapy

1990 • 199 citations

Extrinsic risk factors for pneumonia in the patient at high risk of infection

1984 • 193 citations

Favorable outcome of invasive aspergillosis in patients with acute leukemia.

1987 • 190 citations

Antifungal Prophylaxis with Itraconazole in Prolonged Neutropenia: Correlation with Plasma Levels

1989 • 189 citations

Candida and Aspergillus Infections in Immunocompromised Patients: An Overview

1991 • 183 citations

Prophylactic Intravenous Amphotericin B in Neutropenic Autologous Bone Marrow Transplant Recipients

1992 • 171 citations

An approach to intensive antileukemia therapy in patients with previous invasive aspergillosis

1988 • 169 citations

Ketoconazole vs. Itraconazole for Antifungal Prophylaxis in Patients with Severe Granulocytopenia: Preliminary Results of Two Nonrandomized Studies

1987 • 163 citations

Itraconazole, a new triazole that is orally active in aspergillosis

1984 • 160 citations

Nosocomial pneumonia in adult patients undergoing bone marrow transplantation: a 9-year study.

1991 • 158 citations

Phase I trial of recombinant human macrophage colony-stimulating factor in patients with invasive fungal infections

1991 • 156 citations

Corticosteroid treatment as a risk factor for invasive aspergillosis in patients with lung disease.

1991 • 149 citations

Overview of Host Defenses in Fungal Infections

1992 • 143 citations

Invasive Aspergillus Rhinosinusitis in Patients with Acute Leukemia

1991 • 142 citations

Low-dose amphotericin B prophylaxis against invasive Aspergillus infections in allogeneic marrow transplantation

1991 • 138 citations

Nosocomial Fungal Infections: A Classification for Hospital-Acquired Fungal Infections and Mycoses Arising from Endogenous Flora or Reactivation

1988 • 135 citations

Patterns of Infection in Patients with Aplastic Anemia and the Emergence of Aspergillus As a Major Cause of Death

1992 • 128 citations

Prevention of nosocomial aspergillosis

1991 • 122 citations

Long-term follow-up of patients with invasive fungal disease who received adjunctive therapy with recombinant human macrophage colony- stimulating factor

1993 • 121 citations

Amphotericin B: delivery systems

1990 • 121 citations

Invasive fungal disease in pediatric acute leukemia patients with fever and neutropenia during induction chemotherapy: a multivariate analysis of risk factors.

1990 • 120 citations

Reduced renal toxicity and improved clinical tolerance of amphotericin B mixed with Intralipid compared with conventional amphotericin B in neotropenic patients

1992 • 120 citations

Nebulized amphotericin B as prophylaxis against invasive aspergillosis in granulocytopenic patients.

1990 • 119 citations

Recurrent fungal pneumonias in patients with acute nonlymphocytic leukemia undergoing multiple courses of intensive chemotherapy

1988 • 119 citations

Miconazole

1980 • 115 citations

Epidemiology and diagnosis of invasive pulmonary aspergillosis in bone marrow transplant patients: results of a 5 year retrospective study.

1993 • 112 citations

Tissue concentrations and bioactivity of amphotericin B in cancer patients treated with amphotericin B-deoxycholate

1989 • 103 citations

Prevention of Mycoses in Immunocompromised Patients

1987 • 100 citations

Current Role of Therapy with Amphotericin B

1992 • 99 citations

Efficacy of Itraconazole in the Prevention of Fungal Infections Among Neutropenic Patients with Hematologic Malignancies and Intensive Chemotherapy. A Double Blind, Placebo Controlled Study

1993 • 98 citations

Prevention of fungal sepsis in patients with prolonged neutropenia: A randomized, double-blind, placebo-controlled trial of intravenous miconazole

1987 • 96 citations

Aerosol amphotericin B is effective for prophylaxis and therapy in a rat model of pulmonary aspergillosis

1988 • 96 citations

Itraconazole in the Treatment of Human Mycoses: Review of Three Years of Clinical Experience

1987 • 94 citations

Empiric Therapy with Amphotericin B in Febrile Granulocytopenic Patients

1991 • 94 citations

The efficacy of itraconazole against systemic fungal infections in neutropenic patients: A randomised comparative study with amphotericin B

1991 • 92 citations

Invasive pulmonary aspergillosis in adult acute leukemia: clinical clues to its diagnosis.

1985 • 90 citations

Aspergillus sinusitis in cancer patients

1986 • 88 citations

Experience with itraconazole in cryptococcosis and aspergillosis

1989 • 87 citations

A randomized study to compare oral fluconazole to amphotericin B in the prevention of fungal infections in patients with acute leukaemia

1991 • 81 citations

Comparative Trial of Ketoconazole and Nystatin for Prevention of Fungal Infection in Neutropenic Patients Treated in a Protective Environment

1985 • 80 citations

Future Directions of Antifungal Chemotherapy

1992 • 76 citations

Intranasal amphotericin B reduces the frequency of invasive aspergillosis in neutropenic patients

1991 • 72 citations

Aerosol amphotericin B for prevention of invasive pulmonary aspergillosis

1993 • 67 citations

Amphotericin B or ketoconazole therapy of fungal infections in neutropenic cancer patients

1987 • 67 citations

A clinical study of fluconazole for the treatment of deep mycoses

1989 • 66 citations

Protective effect of human granulocyte colony‐stimulating factor (hG‐CSF) on Cryptococcus and Aspergillus infections in normal and immunosuppressed mice

1991 • 66 citations

Invasive pulmonary aspergillosis prior to BMT in acute leukemia patients does not predict a poor outcome.

1993 • 58 citations

Efficacy of fluconazole (UK-49,858) against experimental aspergillosis and cryptococcosis in mice

1987 • 58 citations

Antifungal Prophylaxis in Bone Marrow Transplantation

1990 • 56 citations

Response to Empiric Amphotericin B During Antileukemic Therapy-Induced Granulocytopenia

1991 • 56 citations

New Methods for Delivery of Antifungal Agents

1989 • 55 citations

Plasma itraconazole concentrations in neutropenic patients after repeated high-dose treatment

1992 • 53 citations

A Pilot Study of Prophylactic Aerosolized Amphotericin B In Patients at Risk for Prolonged Neutropenia

1992 • 52 citations

The Toxicity of Daily Inhaled Amphotericin B

1993 • 50 citations

Model of recurrent pulmonary aspergillosis in rats

1991 • 50 citations

Pharmacokinetics of aerosol amphotericin B in rats

1990 • 48 citations

Clinical evaluation of a new lipid-based delivery system for intravenous administration of amphotericin B

1992 • 46 citations

Safety and efficacy of itraconazole in prevention of fungal infections in neutropenic patients.

1991 • 44 citations

Protected environments are discomforting and expensive and do not offer meaningful protection

1984 • 43 citations

Comparison of Azoles against Aspergilli in vitro and in an Experimental Model of Pulmonary Aspergillosis

1992 • 42 citations

Oral and parenteral therapy with saperconazole (R 66905) of invasive aspergillosis in normal and immunocompromised animals

1989 • 41 citations

Amphotericin B vs high-dose ketoconazole for empirical antifungal therapy among febrile, granulocytopenic cancer patients. A prospective, randomized study.

1991 • 41 citations

Combination therapy in a model of pulmonary aspergillosis

1991 • 41 citations

Aerosolized liposomal amphotericin B for treatment of pulmonary and systemic Cryptococcus neoformans infections in mice

1992 • 41 citations

The Use of Amphotericin B in Nosocomial Fungal Infection

1991 • 40 citations

An assessment of the efficacy of antimicrobial prophylaxis in bone marrow autografts.

1991 • 38 citations

Efficacy of Fluconazole in Experimental Invasive Aspergillosis

1990 • 33 citations

Does ketoconazole prevent fungal infection in children treated with high dose chemotherapy and bone marrow transplantation? Results of a randomized placebo-controlled trial.

1991 • 32 citations

Antifungal Prophylaxis in Immunocompromised Hosts

1993 • 28 citations

The Role of Fluconazole in the Early Treatment and Prophylaxis of Experimental Invasive Aspergillosis

1991 • 26 citations

Failure of amphotericin B spray to prevent aspergillosis in granulocytopenic patients.

1989 • 25 citations

Animal Models: Usefulness for Studies of Fungal Pathogenesis and Drug Efficacy in Aspergillosis

1992 • 24 citations

In vitro Antifungal Spectrum of Itraconazole and Treatment of Systemic Mycoses with Old and New Antimycotic Agents

1992 • 23 citations

Evaluation of Bay R 3783 in rodent models of superficial and systemic candidiasis, meningeal cryptococcosis, and pulmonary aspergillosis

1990 • 21 citations

The innocuousness and possible therapeutic use of aerosol amphotericin-B.

1959 • 19 citations

Clinical uses of growth factors

1992 • 15 citations

Short-term Curative Treatment of Aspergillus fumigatus Pneumonia with Fluconazole

1990 • 5 citations