The effects of gender and sex hormones on outcome in rheumatoid arthritis

Interactions Between the Gonadal Steroids and the Immune System

1985 • 1,065 citations

Estrogen Binding, Receptor mRNA, and Biologic Response in Osteoblast-Like Osteosarcoma Cells

1988 • 836 citations

Sex hormones, immune responses, and autoimmune diseases. Mechanisms of sex hormone action.

1985 • 816 citations

Severe functional declines, work disability, and increased mortality in seventy‐five rheumatoid arthritis patients studied over nine years

1984 • 760 citations

Effects of gender and sex steroids on the immune response

1990 • 592 citations

Survival, prognosis, and causes of death in rheumatoid arthritis

1986 • 444 citations

Length of Life and Cause of Death in Rheumatoid Arthritis

1953 • 364 citations

IL-6 production by human articular chondrocytes. Modulation of its synthesis by cytokines, growth factors, and hormones in vitro.

1990 • 361 citations

The development of disability in rheumatoid arthritis

1986 • 317 citations

Sex steroid receptors in peripheral T cells: absence of androgen receptors and restriction of estrogen receptors to OKT8-positive cells.

1983 • 308 citations

Rheumatism in populations

1977 • 297 citations

Onset, Early Stages, and Prognosis of Rheumatoid Arthritis: A Clinical Study of 100 Patients with 11-year Follow-up

1973 • 284 citations

Course and Prognosis in Rheumatoid Arthritis: A Further Report

1964 • 281 citations

Ten year mortality and causes of death in patients with rheumatoid arthritis.

1985 • 266 citations

Sex hormone regulation of in vitro immune response. Estradiol enhances human B cell maturation via inhibition of suppressor T cells in pokeweed mitogen-stimulated cultures.

1981 • 260 citations

Rheumatism in Populations

1977 • 254 citations

The extra-articular features of rheumatoid arthritis

1973 • 243 citations

The effect of pregnancy on rheumatoid arthritis.

1976 • 227 citations

In the Rat, Interleukin- 1α Acts at the Level of the Brain and the Gonads to Interfere with Gonadotropin and Sex Steroid Secretion*

1989 • 215 citations

Androgen replacement therapy in male patients with rheumatoid arthritis

1991 • 213 citations

Prevalence of Rheumatoid Arthritis

1961 • 185 citations

THE INFLUENCE OF THE GONADS AND ADRENAL GLANDS ON THE IMMUNE RESPONSE TO SKIN GRAFTS

1969 • 183 citations

Progression of radiological changes in rheumatoid arthritis.

1984 • 182 citations

Oestrogen and Human T Lymphocytes: Presence of Specific Receptors in the T‐Suppressor/Cytotoxic Subset

1988 • 164 citations

Early rheumatoid disease. I. Onset.

1976 • 161 citations

Onset of symptoms of rheumatoid arthritis in relation to age, sex and menopausal transition.

1990 • 160 citations

Prognosis in rheumatoid arthritis

1979 • 155 citations

Estrogen immunosuppression is regulated through estrogenic responses in the thymus.

1984 • 153 citations

Immunosuppression by sex steroid hormones. The effect upon PHA- and PPD-stimulated lymphocytes.

1977 • 148 citations

The pill, parity, and rheumatoid arthritis

1990 • 146 citations

Sex hormone status of male patients with rheumatoid arthritis: evidence of low serum concentrations of testosterone at baseline and after human chorionic gonadotropin stimulation

1988 • 144 citations

Sex hormone status and osteoporosis in postmenopausal women with rheumatoid arthritis

1988 • 142 citations

The Prevalence of Rheumatoid Arthritis

1972 • 141 citations

Increased Mortality in Rheumatoid Arthritis:The Use of a Medical Information System for Assessment of Death Risks

1982 • 140 citations

Cause and age at death in a prospective study of 100 patients with rheumatoid arthritis.

1981 • 138 citations

Survivorship and Death in Rheumatoid Arthritis

1970 • 135 citations

Sex steroids and the rheumatic diseases

1985 • 133 citations

A Pituitary Growth-Promoting Factor for Articular Chondrocytes in Monolayer Culture

1972 • 127 citations

Androgenic Status and Sexual Function in Males with Rheumatoid Arthritis and Ankylosing Spondylitis

1986 • 126 citations

Androgen receptors in human thymocytes.

1987 • 124 citations

Pregnancy and the risk of developing rheumatoid arthritis

1990 • 115 citations

Onset of symptoms of rheumatoid arthritis in relation to age, sex and menopausal transition

1991 • 115 citations

Female hormones reduce neutrophil responsiveness in vitro

1984 • 113 citations

The protective effect of the oral contraceptive pill on rheumatoid arthritis: An overview of the analytic epidemiological studies using meth-analysis

1990 • 113 citations

Fetal wastage in patients with rheumatoid arthritis.

1986 • 110 citations

HLA and rheumatoid arthritis: a combined analysis of 440 British patients.

1986 • 110 citations

Outcome of pregnancy in patients with autoimmune rheumatic disease before the disease onset.

1988 • 107 citations

The Clinical Features of Rheumatoid Arthritis

1962 • 107 citations

The natural history of rheumatoid arthritis: a fifteen year follow-up study The prognostic significance of features noted in the first year

1984 • 96 citations

Oestradiol- and testosterone-mediated effects on the immune system in normal and autoimmune mice are genetically linked and inherited as dominant traits.

1989 • 96 citations

A clinical study of older age rheumatoid arthritis with comparison to a younger onset group.

1983 • 94 citations

Relation of menstrual cycle phase to symptoms of rheumatoid arthritis

1983 • 92 citations

Low free testosterone levels in rheumatoid arthritis.

1988 • 90 citations

Oestrogen induced suppression of collagen arthritis: I. Long term oestradiol treatment of DBA/1 mice reduces severity and incidence of arthritis and decreases the anti type II collagen immune response.

1987 • 90 citations

Interrelationships of Circulating Maternal Steroid Concentrations in Third Trimester Pregnancies. II. C₁₈and C₁₉Steroids: Estradiol, Estriol, Dehydroepiandrosterone, Dehydroepiandrosterone Sulfate, Δ⁵-Androstenediol, Δ⁴-Androstenedione, Testosterone, and Dihydrotestosterone

1979 • 86 citations

Low adrenal androgenic-anabolic steroids in women with rheumatoid arthritis (RA): Gas-liquid chromatographic studies of RA patients and matched normal control women indicating decreased 11-deoxy-17-ketosteroid excretion

1984 • 86 citations

Sex differences in adrenocortical structure and function. XXVII. The effect of ether stress on ACTH and corticosterone in intact, gonadectomized, and testosterone- or estradiol-replaced rats

1990 • 83 citations

Free and serum testosterone levels in 276 males: A comparative study of rheumatoid arthritis, ankylosing spondylitis and healthy controls

1989 • 82 citations

A critical review of compliance studies in rheumatoid arthritis

1984 • 82 citations

Effects of testosterone, oestradiol and progesterone on immune regulation.

1982 • 80 citations

Disease activity and pregnancy associated alpha 2-glycoprotein in rheumatoid arthritis during pregnancy.

1983 • 80 citations

Significance of positive tests for rheumatoid factor in the prognosis of rheumatoid arthritis. A follow-up study.

1970 • 76 citations

The effect of adult exposure to diethylstilbestrol in the mouse on macrophage function and numbers.

1980 • 75 citations

Clinical responses during gold therapy for rheumatoid arthritis. changes in synovitis, radiologically detectable erosive lesions, serum proteins, and serologic abnormalities

1982 • 74 citations

The Relationship between Rheumatoid Arthritis and Reproductive Function

1989 • 74 citations

Estrogens and Osteoarthritis

1986 • 71 citations

Sex hormonal effects on the severity of streptococcal cell wall‐induced polyarthritis in the rat

1983 • 70 citations

Interleukin 1 stimulation of the hypothalamic-pituitary-adrenal axis

1990 • 70 citations

Sex hormone status in women suffering from rheumatoid arthritis.

1986 • 67 citations

Effect of oestrogen treatment on clinical and laboratory manifestations of rheumatoid arthritis.

1987 • 66 citations

Oestrogen induced suppression of collagen arthritis. IV: Progesterone alone does not affect the course of arthritis but enhances the oestrogen-mediated therapeutic effect

1989 • 65 citations

Estradiol receptors in articular chondrocytes

1982 • 64 citations

Rheumatoid Arthritis and Pregnancy

1989 • 63 citations

PROLONGED HYPOGONADISM IN MALE PATIENTS WITH RHEUMATOID ARTHRITIS DURING FLARES IN DISEASE ACTIVITY

1988 • 63 citations

HLA DR4 and rheumatoid arthritis in Japanese people.

1981 • 59 citations

Estrogenic Regulation of Uterine 90-Kilodalton Heat Shock Protein *

1988 • 58 citations

HLA antigen associations with extra‐articular rheumatoid arthritis

1984 • 58 citations

Effect of sex hormones on NK and ADDC activity of mice

1988 • 57 citations

Stimulation of interleukin-1 production from placental monocytes.

1984 • 56 citations

Estrogen and glucocorticoid receptors in adult canine articular cartilage

1982 • 56 citations

Older age onset rheumatoid arthritis with or without osteoarthritis.

1987 • 53 citations

Expression of Ia and the production of interleukin 1 by peritoneal exudate macrophages activated by steroids

1986 • 53 citations

Is poor pregnancy outcome a risk factor in rheumatoid arthritis?

1990 • 49 citations

Orchidectomy and the immune response II. Response of orchidectomized mice to antigens

1974 • 48 citations

A COMPARISON OF DISABILITY MEASURED BY THE STANFORD HEALTH ASSESSMENT QUESTIONNAIRE DISABILITY SCALES (HAQ) IN MALE AND FEMALE RHEUMATOID OUTPATIENTS

1991 • 48 citations

Drug Compliance in Outpatients with Rheumatoid Arthritis

1979 • 47 citations

Rheumatoid arthritis in the aged

1951 • 46 citations

Significance of the Waaler-Rose Test, Streptococcal Agglutination, and Antistreptolysin Titre in the Prognosis of Rheumatoid Arthritis

1959 • 44 citations

Relation of the Adrenal Cortex to Rheumatic Disease: A Review of Some Recent Investigations

1950 • 43 citations

Menstrual cyclicity of finger joint size and grip strength in patients with rheumatoid arthritis.

1983 • 43 citations

Factors Related to the Progression of Joint Destruction in Rheumatoid Arthritis

1984 • 42 citations

Transforming Growth Factor‐β in Rheumatoid Arthritis

1990 • 39 citations

Are certain HLA haplotypes responsible for low testosterone levels in males?

1989 • 39 citations

Cartilage of the baboon contains estrogen receptors

1985 • 39 citations

Report on an Enquiry into the Aetiological Factors associated with Rheumatoid Arthritis

1953 • 37 citations

Norethynodrel With Mestranol in Treatment of Rheumatoid Arthritis

1964 • 37 citations

Clinical, laboratory and radiographic features in early rheumatoid arthritis.

1990 • 37 citations

Pregnancy and its effect on the risk of developing rheumatoid arthritis.

1991 • 36 citations

Diminished incidence of severe rheumatoid arthritis associated with oral contraceptive use

1990 • 35 citations

A Survey of Rheumatoid Arthritis in West Cornwall: A Report to the Empire Rheumatism Council

1958 • 35 citations

Factors influencing mortality in rheumatoid arthritis

1986 • 33 citations

Pharmacological actions of 17β-oestradiol on articular cartilage chondrocytes and chondrosarcoma chondrocytes in the absence of oestrogen receptors

1988 • 33 citations

An attempt to predict the response to gold therapy in rheumatoid arthritis

1984 • 33 citations

Rheumatoid Arthritis in the Elderly

1986 • 33 citations

THE ONSET OF RHEUMATOID ARTHRITIS IN THE AGED

1967 • 32 citations

Ontogenetic Aspects of Sexual Dimorphism and the Primary Immune Response to Sheep Erythrocytes in Hamsters from Prepuberty through Senescence

1976 • 32 citations

Modulatory effects of oestrogen on immunological responsiveness. II. Suppression of tumour-associated immunity in patients with prostatic cancer.

1979 • 31 citations

Effect of adjuvant-induced arthritis on serum luteinizing hormone and testosterone concentrations in the male rat

1987 • 30 citations

Intraarticular progesterone: effects of a local treatment for rheumatoid arthritis.

1988 • 28 citations

Oral Contraceptive Treatment for Rheumatoid Arthritis: An Open Study in 10 Female Patients

1989 • 27 citations

Australian mortality statistics for rheumatoid arthritis 1950-81: analysis of death certificate data.

1988 • 26 citations

JOINT SIZE INFLUENCE ON THE LEUCOCYTE COUNT OF INFLAMMATORY SYNOVIAL FLUIDS

1989 • 26 citations

Role of prostaglandins in the control of pituitary hormone secretion.

1981 • 26 citations

Hormone Suppression of DNA Synthesis in Cultured Chondrocyte and Osteosarcoma Cell Lines

1975 • 26 citations

Sequential gold and penicillamine therapy in rheumatoid arthritis

1982 • 24 citations

Interrelationship between the Immunological and Steroid Hormone Parameters in Rheumatoid Arthritis¹)

2009 • 24 citations

Rheumatoid Arthritis: Types of Course and Prognosis

1968 • 23 citations

Rheumatoid arthritis: types of course and prognosis.

1968 • 23 citations

Menopause Arthralgia

1938 • 20 citations

Evaluation of the Progression of Rheumatoid Arthritis

1980 • 20 citations

RHEUMATOID ARTHRITIS IN THE ELDERLY

1956 • 19 citations

The relationships of SHBG with current and previous use of oral contraceptives and oestrogen replacement therapy

1989 • 18 citations

IMMUNOREACTIVE CIRCULATING ALPHA-INTERFERON IS LOW IN SJÖGREN'S SYNDROME

1990 • 18 citations

Suppression of immune responses by progesterone.

1980 • 16 citations

Effect of Estrone and Progesterone on Adjuvant Arthritis in Rats

1967 • 16 citations

Sex hormones and metabolism of glycosaminoglycans. I. Effect of orchidectomy and administration of testosterone in rabbits

1976 • 14 citations

Clinical Features in Subacute Rheumatoid Arthritis in Old Age

1968 • 13 citations

HLA‐DR4 genotype frequency and gender effect in familial rheumatoid arthritis

1988 • 13 citations

Study on the inactivation mechanism of androgens in rheumatoid arthritis: excretory rate of free and conjugated 17-ketosteroids.

1979 • 11 citations

The Treatment of Atrophic Arthritis with Estrogenic Substance

1940 • 11 citations

Hormonal regulation of lymphocyte functions.

1987 • 11 citations

Heat shock proteins: the missing link between hormonal and reproductive factors and rheumatoid arthritis?

1991 • 11 citations

EFFECT OF LARGE DOSES OF PROGESTERONE IN RHEUMATOID ARTHRITIS

1951 • 10 citations

THE CONCENTRATION AND SYNTHESIS OF GLYCOSAMINOGLYCANS IN THE SKIN AND TRACHEAL CARTILAGE OF NORMAL AND ORCHIDECTOMIZED RATS INJECTED WITH TESTOSTERONE

1970 • 10 citations

Effect of Pregnancy, Castration, Testosterone, Ethisterone, Oestradiol Benzoate and Stilboestrol on the Exchangeable Sulphate Pool and on Sulphate Incorporation in Vivo into Costal Cartilage of the Mouse

1971 • 8 citations

[Rheumatoid arthritis treated by norethynodrel associated with mestranol: clinical aspects and laboratory tests].

1966 • 8 citations

Biomarks in secondary osteoporosis

1989 • 7 citations

Effects of somatomedin and other factors on glycosaminoglycan synthesis in cultured rat chondrocytes.

1983 • 5 citations

Effect of steroid hormones on endotoxin-mediated cartilage degradation

1988 • 5 citations

Rheumatoid arthritis: similarity of radiographic abnormalities in men and women.

1988 • 4 citations

The role of estrogen and oophorectomy in immune synovitis

1981 • 3 citations

Deleted Work

1955 • 0 citations