Central nervous system binding sites for calcitonin and calcitonin gene-related peptide

Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing

1983 • 2,298 citations

Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products

1982 • 2,114 citations

Transforming growth factor beta

2011 • 1,990 citations

Transforming growth factor α

1988 • 707 citations

Expression in Brain of a Messenger RNA Encoding a Novel Neuropeptide Homologous to Calcitonin Gene-Related Peptide

1985 • 611 citations

Expression Cloning of an Adenylate Cyclase-Coupled Calcitonin Receptor

1991 • 458 citations

Abundant calcitonin receptors in isolated rat osteoclasts. Biochemical and autoradiographic characterization.

1986 • 456 citations

Calcitonin gene-related peptide: Detailed immunohistochemical distribution in the central nervous system

1985 • 424 citations

The cell surface receptors for interleukin-1α and interleukin-1β are identical

1986 • 422 citations

Stimulation of noradrenergic sympathetic outflow by calcitonin gene-related peptide

1983 • 396 citations

Parathyroid Hormone-Related Protein of Malignancy: Active Synthetic Fragments

1987 • 374 citations

A second human calcitonin/CGRP gene

1985 • 363 citations

hCGRP8-37, a calcitonin gene-related peptide antagonist revealing calcitonin gene-related peptide receptor heterogeneity in brain and periphery.

1990 • 327 citations

Topographic localization of calcitonin gene-related peptide in the rat brain: An immunohistochemical analysis

1985 • 304 citations

Interaction of Calcitonin and Calcitonin Gene-Related Peptide at Receptor Sites in Target Tissues

1985 • 286 citations

Calcitonin gene-related peptide and its binding sites in the human central nervous system and pituitary.

1985 • 281 citations

Possible involvement of two proteins (phosphoprotein and CD9(p24)) in regulation of platelet calcium fluxes

1985 • 243 citations

Structure-activity profile of calcitonin gene-related peptide in peripheral and brain tissues. Evidence for receptor multiplicity.

1989 • 222 citations

Identification of a common class of high affinity receptors for both types of porcine interleukin-1 on connective tissue cells

1986 • 219 citations

Calcitonin gene-related peptide (CGRP) in the rat central nervous system: patterns of immunoreactivity and receptor binding sites

1988 • 213 citations

Calcitonin: regional distribution of the hormone and its binding sites in the human brain and pituitary.

1981 • 205 citations

Calcitonin/calcitonin gene-related peptide transcription unit: tissue-specific expression involves selective use of alternative polyadenylation sites.

1984 • 202 citations

Immunohistochemical evidence for the coexistence of calcitonin gene-related peptide- and choline acetyltransferase-like immunoreactivity in neurons of the rat hypoglossal, facial and ambiguus nuclei

1985 • 200 citations

Effect of calcitonin gene-related peptide on contraction of striated muscle in the mouse

1985 • 180 citations

Calcitonin Receptors in the Central Nervous System of the Rat*

1981 • 161 citations

Structural and functional homologies in the receptors for insulin and the insulin-like growth factors

1982 • 154 citations

Lack of opiate receptor involvement in centrally induced calcitonin analgesia

1978 • 154 citations

Autoradiographic distribution of 125I calcitonin gene-related peptide binding sites in the rat central nervous system

1985 • 152 citations

The gustatory neocortex of the rat

1982 • 152 citations

Intraventricular Calcitonin Inhibits Gastric Acid Secretion

1981 • 151 citations

Effects of calcitonin gene-related peptide on food intake

1984 • 148 citations

Autoradiographic localization of calcitonin gene-related peptide binding sites in human and rat brains

1986 • 138 citations

Expression of dopaminergic phenotypes in the mouse olfactory bulb induced by the calcitonin gene-related peptide

1989 • 132 citations

N. raphe magnus lesions disrupt stimulation-produced analgesia from ventral but not dorsal midbrain areas in the rat

1983 • 126 citations

Calcitonin gene-related peptide receptor in cultured vascular smooth muscle and endothelial cells

1988 • 125 citations

Localization of calcitonin binding sites in rat central nervous system: Evidence of its neuroactivity

1983 • 124 citations

Characterization and regional distribution of calcitonin binding sites in the rat brain

1981 • 110 citations

SALMON AND HUMAN CALCITONIN-LIKE PEPTIDES COEXIST IN THE HUMAN THYROID AND BRAIN

1983 • 107 citations

Localization of binding sites for calcitonin gene-related peptide in rat brain by in vitro autoradiography

1986 • 103 citations

Inhibition of gastric acid secretion by intracerebral injection of calcitonin gene related peptide in rats

1984 • 102 citations

Synthesis of biologically active rat transforming growth factor I

1984 • 102 citations

Distinct binding sites for calcitonin gene-related peptide and salmon calcitonin in rat central nervous system

1985 • 100 citations

Evidence for a new subclass of calcitonin/ calcitonin gene-related peptide binding site in rat brain

1988 • 99 citations

Properties of a calcitonin receptor and adenylate cyclase in BEN cells, a human cancer cell line.

1980 • 95 citations

Solution structure of human calcitonin gene-related peptide by proton NMR and distance geometry with restrained molecular dynamics

1991 • 93 citations

Localization of salmon calcitonin binding sites in rat brain by autoradiography

1983 • 88 citations

The Calcitonin Gene Peptides: Biology and Clinical Relevance

1990 • 86 citations

Placental Lactogen and Growth Hormone Receptors in Human Fetal Tissues: Relationship to Fetal Plasma Human Placental Lactogen Concentrations and Fetal Growth*

1988 • 84 citations

Conserved and unique amino acid residues in the domains of the growth hormones

1989 • 77 citations

Central nervous system actions of calcitonin gene-related peptide on gastric acid secretion in the rat

1985 • 76 citations

Calcitonin/Calcitonin Gene-Related Peptide Transcription Unit: Tissue-Specific Expression Involves Selective Use of Alternative Polyadenylation Sites

1984 • 73 citations

Specific binding of 125I-salmon calcitonin to rat brain: Regional variation and calcitonin specificity.

1981 • 71 citations

The Evolution of Peptide Hormones

1982 • 71 citations

CALCITONIN GENE-RELATED PEPTIDE MIMICS CALCITONIN ACTIONS IN BRAIN ON GROWTH HORMONE RELEASE AND FEEDING

1985 • 68 citations

Binding sites for calcitonin gene-related peptide in distinct areas of rat brain

1985 • 67 citations

Cell biology of bone.

1988 • 64 citations

Calcitonin gene-related peptide (CGRP)-immunoreactive sensory and motor nerves of the mammalian palate

1985 • 62 citations

Comparison of binding sites for the calcitonin gene-related peptides I and II in man

1987 • 59 citations

Calcitonin receptors in the rat mesencephalon mediate its analgesic actions: Autoradiographic and behavioral analysis

1985 • 57 citations

Localization and characterization of renal calcitonin receptors by in vitro autoradiography

1987 • 56 citations

Two-dimensional NMR and structure determination of salmon calcitonin in methanol

1991 • 56 citations

Calcitonin inhibition of physiological and stimulated prolactin secretion in rats

1981 • 55 citations

Immunoreactive calcitonin in the central nervous system of the pigeon

1981 • 55 citations

Calcitonin gene-related peptide (hCGRPα) binding sites in the nucleus accumbens. Atypical structural requirements and marked phylogenic differences

1991 • 54 citations

Hindbrain and spinal cord

1985 • 54 citations

Presence of immunoreactive calcitonin in the hypothalamus and pituitary lobes of rats

1981 • 54 citations

The analgesic activity of calcitonin and the central serotonergic system

1985 • 53 citations

Elucidation of the nucleotide sequence of chicken calcitonin mRNA: direct evidence for the expression of a lower vertebrate calcitonin-like gene in man and rat.

1985 • 50 citations

Angiotensin II receptors and angiotensin converting enzyme in the medulla oblongata.

1987 • 48 citations

Evidence for Calcitonin Receptor Heterogeneity: Binding Studies with Nonhelical Analogs*

1990 • 43 citations

Inhibition of gastric acid secretion by brain peptides in the dog

1986 • 42 citations

Brain Receptors for Blood-Borne Calcitonin in Rats: Circumventricular Localization and Vasopressin-Resistant Deficiency in Hereditary Diabetes Insipidus*

1982 • 42 citations

Examination of Interspecies Differences in Renal and Skeletal Receptor Binding and Adenylate Cyclase Stimulation with Human Calcitonin*

1980 • 40 citations

Characterization of picomolar affinity binding sites for [125I]-human calcitonin gene-related peptide in rat brain and heart

1987 • 40 citations

Biologically potent analogues of salmon calcitonin which do not contain an N-terminal disulfide-bridged ring structure

1987 • 40 citations

Calcitonin: brainstem microinjection but not systemic administration inhibits spinal nociceptive transmission in the cat

1986 • 38 citations

Further evidence for calcitonin gene duplication: the identification of two different calcitonins in a fish, a reptile and two mammals

1982 • 38 citations

Calcitonin gene-related peptide: Brain and spinal action on intestinal motility

1985 • 37 citations

Hypoprolactinemic Action of Calcitonin and the Tuberoinfundibular Dopaminergic System

1983 • 36 citations

Eel calcitonin binding site distribution and antinociceptive activity in rats

1986 • 35 citations

Effects of calcitonin on rat extrapyramidal motor system: behavioral and biochemical data

1982 • 34 citations

Calcitonin—C.N.S. action to control the pattern of intestinal motility in rats

1983 • 34 citations

Calcitonin and CGRP inhibit gastrointestinal transit via distinct neuronal pathways

1988 • 33 citations

Calcitonin-induced anorexia in rats: Evidence for its inhibitory action on lateral hypothalamic chemosensitive neurons

1986 • 33 citations

Antinociceptive activity of salmon calcitonin injected intraventricularly in mice: modulation of morphine antinociception.

1986 • 31 citations

Identification of a receptor for calcitonin gene-related peptides I and II in human cerebellum

1988 • 29 citations

IDENTIFICATION OF BOTH HUMAN AND SALMON CALCITONIN-LIKE MOLECULES IN BIRDS SUGGESTING THE EXISTENCE OF TWO CALCITONIN GENES

1982 • 29 citations

Calcitonin Gene‐Related Peptide‐Binding Sites of Porcine Cardiac Muscles and Coronary Arteries: Solubilization and Characterization

1989 • 27 citations

Salmon calcitonin in lizard brain: a possible neuroendocrine transmitter

1982 • 26 citations

Positive inotropic effects and receptors of calcitonin gene-related peptide(CGRP) in porcine ventricular muscles

1988 • 24 citations

Central nervous system effect of calcitonin: Stimulation of prolactin release in rats

1982 • 21 citations

Intracerebroventricular Injection of 125I-Salmon Calcitonin in Rats: Fate, Anorexia and Hypocalcemia

1985 • 21 citations

Mechanisms of Calcitonin-Induced Growth Hormone (GH) Suppression: Roles of Somatostatin and GH-Releasing Factor*

1987 • 21 citations

Cerebroventricular calcitonin gene-related peptide inhibits rat duodenal bicarbonate secretion by release of norepinephrine and vasopressin.

1990 • 20 citations

Anatomical mapping of the rat hypothalamus for calcitonin-induced anorexia

1987 • 20 citations

Distribution of Intraventricular Salmon Calcitonin and Suppression of Gastric Secretion

1985 • 18 citations

Central cardiovascular effects of calcitonin gene-related peptide: interaction with noradrenaline in the nucleus tractus solitarius of rats

1988 • 18 citations

Solubilization and Characterization of Calcitonin Gene‐Related Peptide Binding Site from Porcine Spinal Cord

1988 • 17 citations

Calcitonin as a feeding suppressant: Localization of central action to the cerebral III ventricle

1987 • 17 citations

A human calcitonin-like molecule in the ultimobranchial body of the amphibia (Rana pipiens)

1981 • 16 citations

Effects of salmon calcitonin on plasma renin activity and systolic blood pressure in the rat

1986 • 16 citations

Reversible calcitonin binding to solubilized sheep brain binding sites

1991 • 16 citations

Calcitonin binding site distribution in the cat central nervous system: A wider insight of the peptide involvement in brain functions

1987 • 15 citations

Antagonistic behavioral effects of calcitonin and amphetamine in the rat

1986 • 15 citations

Inhibitory effects of calcitonin on adenylate cyclase activity in different rat brain areas

1986 • 15 citations

Analogue separates biological effects of salmon calcitonin on brain and renal cortical membranes

1988 • 13 citations

Effect of calcitonin on ACTH secretion

1984 • 12 citations

Effects of human calcitonin on water and electrolyte movements in rat juxtamedullary nephrons: inhibition of medullary K recycling

1986 • 11 citations

Inhibition of gastric acid secretion by brain peptides in the dog

1986 • 10 citations

Effects of age on binding sites for calcitonin generelated peptide in the rat central nervous system

1989 • 10 citations

Calcitonin and calcitonin gene-related peptide in the human brain.

1984 • 9 citations

Calcitonin inhibits the phosphorylation of various proteins in rat brain synaptic membranes

1985 • 9 citations

Evolutionary pathways of the calcitonin genes

1988 • 9 citations

Motor effects of calcitonin administered intracerebroventricularly in the rat

1986 • 9 citations

Regional localization of the antagonism of amphetamine-induced hyperactivity by intracerebral calcitonin injections

1987 • 9 citations

[Possible trophic role on the neuromuscular junction of a neuropeptide co-existing with acetylcholine in motor neurons of the spinal cord].

1989 • 8 citations

Intracerebroventricular administration of calcitonin enhances glucose-stimulated release of insulin

1989 • 7 citations

Characterization of sheep brain calcitonin receptors.

1990 • 2 citations