Interferons: Rationale for Clinical Trials in Neoplastic Disease

pppA2'p5'A2'p5'A: an inhibitor of protein synthesis synthesized with an enzyme fraction from interferon-treated cells.

1978 • 787 citations

Enhanced NK cell activity in mice injected with interferon and interferon inducers

1978 • 735 citations

Augmentation by interferon of human natural and antibody-dependent cell-mediated cytotoxicity

1979 • 532 citations

Effect of Human Leukocyte Interferon on Hepatitis B Virus Infection in Patients with Chronic Active Hepatitis

1976 • 505 citations

Interferon-mediated protein kinase and low-molecular-weight inhibitor of protein synthesis

1976 • 435 citations

Human Leukocyte Interferon for the Treatment of Herpes Zoster in Patients with Cancer

1978 • 359 citations

Interferon, double-stranded RNA, and protein phosphorylation.

1976 • 328 citations

Controlled Clinical Trial of Prophylactic Human-Leukocyte Interferon in Renal Transplantation

1979 • 322 citations

Interferon action may be mediated by activation of a nuclease by pppA2′p5′A2′p5′A

1978 • 310 citations

Enhancement by Interferon of the Specific Cytotoxicity of Sensitized Lymphocytes

1972 • 308 citations

THE LINKAGE OF GENES FOR THE HUMAN INTERFERON-INDUCED ANTIVIRAL PROTEIN AND INDOPHENOL OXIDASE-B TRAITS TO CHROMOSOME G-21

1973 • 291 citations

Interferon: An Inducer of Macrophage Activation by Polyanions

1977 • 275 citations

Preliminary Observations on the Effect of Human Leukocyte Interferon in Non-Hodgkin's Lymphoma

1978 • 267 citations

A Modified Polyriboinosinic-Polyribocytidylic Acid Complex That Induces Interferon in Primates

1975 • 264 citations

2-5A synthetase: assay, distribution and variation with growth or hormone status

1979 • 260 citations

Human leukocyte interferon: production, purification to homogeneity, and initial characterization.

1979 • 233 citations

Interferon action: two distinct pathways for inhibition of protein synthesis by double-stranded RNA.

1978 • 216 citations

Enhanced expression of β ₂ -microglobulin and HLA antigens on human lymphoid cells by interferon

1978 • 215 citations

Regulation of Macrophage Tumoricidal Function: A Role for Prostaglandins of the E Series

1978 • 214 citations

Enhancement by Interferon of the Expression of Surface Antigens on Murine Leukemia L 1210 Cells

1973 • 204 citations

Purification of mouse interferon by sequential affinity chromatography on poly(U)– and antibody–agarose columns

1978 • 203 citations

Enhancement of Phagocytosis by Interferon-Containing Preparations

1971 • 201 citations

Isolation of two interferon-induced translational inhibitors: a protein kinase and an oligo-isoadenylate synthetase.

1978 • 194 citations

Clinical and Laboratory Investigations on Man: Systemic Administration of Potent Interferon to Man234

1973 • 192 citations

Antiviral activity of interferons

1977 • 189 citations

Two antigenically distinct species of human interferon.

1975 • 189 citations

Sensitivity of the Epstein-Barr Virus Transformed Human Lymphoid Cell Lines to Interferon

1975 • 185 citations

Interferon affects both G1 and S+G2 in cells stimulated from quiescence to growth

1978 • 184 citations

Effects of Interferon on Antibody Synthesis in Vitro

1974 • 183 citations

Regulatory Effect of Interferon on T Cells in Vitro

1976 • 181 citations

Interferon: purification and initial characterization from human diploid cells.

1976 • 175 citations

Pronounced antiviral activity of human interferon on bovine and porcine cells

1974 • 174 citations

Activation of Human Natural Killer Cells Cytotoxic for Human Leukemia Cells by Purified Interferon

1979 • 168 citations

Synthesis of an Oligonucleotide Inhibitor of Protein Synthesis in Rabbit Reticulocyte Lysates Analogous to that Formed in Extracts from Interferon‐Treated Cells

1978 • 164 citations

Interferon and spontaneous cytotoxicity in man. I. Enhancement of the spontaneous cytotoxicity of peripheral lymphocytes by human leukocyte interferon

1978 • 151 citations

Antitumor Effects of Interferon Preparations In Mice

1970 • 151 citations

Interferon action: Role of membrane gangliosides

1976 • 144 citations

Stimulation of prostaglandin E production in cultured human fibroblasts by poly(I) · poly(C) and human interferon

1977 • 139 citations

Effect of interferon on exogenous, endogenous, and chronic murine leukemia virus infection

1976 • 137 citations

Interferon and Cell Division. IX. Interferon-Resistant L1210 Cells: Characteristics and Origin2

1974 • 132 citations

Structural requirements of the rIn·rCn complex for Induction of human interferon

1972 • 130 citations

Identification of the cell multiplication inhibitory factors in interferon preparations as interferons

1976 • 129 citations

Interferon Preparations as Modifiers of Immune Responses

1972 • 125 citations

Mechanism of the Suppressive Effect of Interferon on Antibody Synthesis in Vivo

1975 • 125 citations

Cytotoxic effects of interferon in vitro on granulocytic progenitor cells.

1977 • 124 citations

Administration of Human Leukocyte Interferon in Herpes Zoster. I. Safety, Circulating Antiviral Activity, and Host Responses to Infection

1974 • 124 citations

Antibodies to a cell-surface component coded by human chromosome 21 inhibit action of interferon

1976 • 124 citations

Inhibition of the Primary in Vitro Antibody Response by Interferon Preparations

1975 • 123 citations

Effect of human leukocyte interferon on the growth of human osteosarcoma cells in tissue culture

1977 • 118 citations

Cure of Murine Leukemia With Drug and Interferon Treatment

1973 • 115 citations

Progressive glomerulonephritis in mice treated with interferon preparations at birth

1976 • 115 citations

Binding of human fibroblast interferon to concanavalin A-agarose. Involvement of carbohydrate recognition and hydrophobic interaction

1976 • 112 citations

Antitumor Effects Of Interferon

1973 • 111 citations

Localization of the Gene AVG for the Antiviral Expression of Immune and Classical Interferon to the Distal Portion of the Long Arm of Chromosome 21

1976 • 110 citations

Suppression of Mouse Antibody Producing Spleen Cells by Various Interferon Preparations

1973 • 109 citations

Trends and variability in survival from osteosarcoma.

1978 • 108 citations

Interferon, double-stranded RNA and mRNA degradation

1976 • 104 citations

Differential Effects of Interferon on the Expression of H-2K, H-2D, and Ia Antigens on Mouse Lymphocytes

1977 • 102 citations

Interferon and Spontaneous Cytotoxicity in Man

1978 • 101 citations

TOPICAL THERAPY OF ULCERATIVE HERPETIC KERATITIS WITH HUMAN INTERFERON

1976 • 100 citations

Use of thyrotropin and cholera toxin to probe the mechanism by which interferon initiates its antiviral activity.

1976 • 99 citations

Interferon suppresses the transition of quiescent 3T3 cells to a growing state

1977 • 96 citations

Molecular heterogeneity of human leukocyte interferon: Two populations differing in molecular weights, requirements for renaturation, and cross-species antiviral activity

1975 • 93 citations

High-dose methotrexate in osteogenic sarcoma: a 5-year experience.

1978 • 90 citations

Efficacy of combined interferon cyclophosphamide therapy after diagnosis of lymphoma in AKR mice

1978 • 89 citations

Synthesis of human interferon by Xenopus laevis oocytes: two structural genes for interferons in human cells.

1977 • 87 citations

Tumour cell lines induce interferon in human lymphocytes

1977 • 86 citations

Human lymphoblastoid interferon. Large scale production and partial purification.

1977 • 85 citations

Relationships of the structure and function of the interferon receptor to hormone receptors and establishment of the antiviral state.

1978 • 85 citations

Physical, morphological, and biochemical alterations in the membrane of AKR mouse cells after interferon treatment.

1978 • 80 citations

Enhancement of T Cell Cytotoxic Responses by Purified Human Fibroblast Interferon

1978 • 80 citations

Elimination of size and charge heterogeneities of human leukocyte interferons by chemical cleavage

1977 • 79 citations

Interferon Therapy in Hodgkin's Disease

1976 • 79 citations

Cyclic AMP Potentiation of Interferon Antiviral Activity and Effect of Interferon on Cellular Cyclic AMP Levels

1975 • 78 citations

Inhibition by Interferon of Thymidine Uptake in Chemostat Cultures of L1210 Cells

1978 • 76 citations

A cell surface alteration in mouse L cells induced by interferon

1977 • 76 citations

Circulating Human Interferon after Intramuscular Injection into Animals and Man

1974 • 70 citations

Inhibition by Interferon Preparations of a Solid Malignant Tumour and Pulmonary Metastases in Mice

1972 • 69 citations

Interferon and cyclic-3′5′-adenosine monophosphate: Potentiation of antiviral activity

1969 • 66 citations

Chromosome 21 and the cell growth inhibitory effect of human interferon preparations

1976 • 65 citations

The Somatic Cell Genetics of Human Interferon: Assignment of Human Interferon Loci to Chromosomes 2 and 5

1974 • 57 citations

Inhibition of Haemopoietic Colony Growth by Interferon Preparations from Different Sources

1973 • 53 citations

Purification and characterization of human leukocyte interferon components.

1976 • 52 citations

Aging in vitro and large-scale interferon production by 15 new strains of human diploid fibroblasts

1978 • 52 citations

Fibroblast interferon in man is coded by two loci on separate chromosomes

1979 • 52 citations

Adjuvant Interferon Treatment of Human Osteosarcoma

1979 • 52 citations

Prostaglandin Restoration of the Interferon Response of Hyporeactive Animals

1978 • 51 citations

Distinct Molecular Species of Human Interferons: requirements for Stabilization and Reactivation of Human Leukocyte and Fibroblast Interferons

1975 • 50 citations

Cell-free synthesis of human interferon.

1975 • 49 citations

Interferon and murine leukemia. VII. Therapeutic effect of interferon preparations after diagnosis of lymphoma in akr mice

1976 • 49 citations

Chromosomal localization of human genes governing the interferon-induced antiviral state.

1975 • 48 citations

Human fibroblast interferon in human neoplasia: clinical and laboratory study.

1978 • 48 citations

Comparative chemotherapy of AKR lymphoma and human hematological neoplasia.

1974 • 47 citations

Amputation and adriamycin in primary osteosarcoma: a 5-year report.

1978 • 43 citations

Chemical Carcinogenesis in Mice inhibited by Interferon

1972 • 42 citations

Nature of the molecular heterogeneity of human leukocyte interferon

1976 • 41 citations

An integrated and comparative study of the antiviral effects and other biological properties of the polyinosinic acid-polycytidylic acid and its mismatched analogues.

1976 • 40 citations

Inhibition of Herpesvirus hominis replication by human interferon

1975 • 37 citations

Comparation Interferon-Inducing and Antiviral Properties of 2-Amino-5-Bromo-6-Methyl-4-Pyrimidinol (U-25,166), Tilorone Hydrochloride, and Polyinosinic-Polycytidylic Acid

1977 • 36 citations

Interferon Induced Growth Depression in Diploid and Heteroploid Human Cells

1972 • 36 citations

Inhibition of Spontaneous Mammary Carcinoma of Mice by Treatment with Interferon and Poly I:C

1971 • 35 citations

The Role of Human Chromosome 21 in Sensitivity to Interferons

1977 • 33 citations

Inhibition of Radiogenic Lymphoma Development in Mice by Interferon

1971 • 32 citations

Correlation of physicohemical and antigenic properties of human leukocyte interferon subspecies

1977 • 31 citations

Interferon inhibits the release of plasminogen activator from SV3T3 cells

1978 • 31 citations

Effect of interferon on lymphocyte transformation and nuclear antigen production by Epstein–Barr virus

1976 • 29 citations

Inhibition of Growth and Transformation of Human Cells by Interferon 2

1973 • 23 citations

Production of interferon and serum hyporeactivity factor in mice infected with murine cytomegalovirus

1978 • 22 citations

The effect of mouse interferon on the transformation of NIH/3T3 mouse cells by murine sarcoma Virus

1978 • 22 citations

Interferon and Host Resistance to Rauscher Virus-induced Leukemia

1969 • 20 citations

Hyporeactivity to interferon induction: characterization of a hyporeactive factor in the serum of encephalomyocarditis virus-infected mice

1975 • 19 citations

The interferon refractory state. II. Biological characterization of a refractoriness-inducing protein.

1975 • 18 citations

Inhibition of Oncogenicity of Murine Sarcoma Virus (Harvey) in Mice by Interferon

1970 • 18 citations

Pilot studies with human interferon in Herpesvirus saimiri-induced lymphoma in owl monkeys.

1976 • 13 citations

FUNCTIONAL AND ULTRASTRUCTURAL STUDIES OF THE EFFECTS OF HUMAN INTERFERON ON CELL MEMBRANES OF IN VITRO CULTURED CELLS

1976 • 9 citations

Differential Production of Interferon and Refractoriness Inducing Principle in L Cells

1974 • 9 citations

Interferons and inducers in vivo

1979 • 7 citations

An inhibitor of the complement-fixation reaction associated with interferon treatment

1976 • 6 citations