Opiate agonist action of antidiarrheal agents in vitro and in vivo?Findings in support for selective action

Opiate Receptor: Demonstration in Nervous Tissue

1973 • 2,364 citations

The Pharmacological Basis of Therapeutics

1976 • 1,403 citations

Opiates and endogenous opioid peptides

1977 • 1,282 citations

Opiate Receptor Binding of Agonists and Antagonists Affected Differentially by Sodium

1974 • 554 citations

Opiate Agonists and Antagonists Discriminated by Receptor Binding in Brain

1973 • 527 citations

Narcotic Analgesics and Antagonists

1971 • 309 citations

In Vitro Models in the Study of Structure-Activity Relationships of Narcotic Analgesics

1975 • 289 citations

STIMULANT ACTIONS OF VOLATILE ANAESTHETICS ON SMOOTH MUSCLE

1964 • 261 citations

Physicochemical Properties, Solubility, and Protein Binding of Δ9 -Tetrahydrocannabinol

1974 • 212 citations

Receptor binding and pharmacological activity of opiates in the guinea-pig intestine.

1975 • 182 citations

Effect of 6-hydroxydopamine, 5,6-dihydroxytryptamine and raphe lesions on the antinociceptive actions of morphine in rats

1973 • 89 citations

Studies of the enterohepatic circulation of morphine in the rat.

1975 • 73 citations

Synthetic antidiarrheal agents. 2,2-Diphenyl-4-(4'-aryl-4'-hydroxypiperidino)butyramides

1973 • 71 citations

Loperamide (R 18 553), a novel type of antidiarrheal agent. Part 5: the pharmacokinetics of loperamide in rats and man.

1974 • 65 citations

Loperamide binding to opiate receptor sites of brain and myenteric plexus.

1976 • 63 citations

Stimulation of Cells by Antibody

1973 • 60 citations

Unexpected reversal effects of naloxone on the guinea pig ileum

1976 • 54 citations

Acute effects of morphine on rat intestinal motility

1976 • 50 citations

Effects of E prostaglandins, diphenoxylate and morphine on intestinal motility in vivo

1975 • 47 citations

Synthesis Anti-diarrhoeal Agents--I. Some Pharmacological Properties of R 1132 and Related Compounds

1959 • 35 citations

Rates of onset and offset of action of narcotic analgesics in isolated preparations

1975 • 33 citations

Comparison between Narcotic “Receptors” in the Guinea‐pig Ileum and the Rat Brain

1975 • 32 citations

Synthetic Antidiarrheal Drugs

1977 • 27 citations

Differential Response of Longitudinal and Circular Muscles of Intact Canine Colon to Morphine and Bethanechol

1971 • 24 citations

Hydrophobic interactions responsible for unspecific binding of morphine-like drugs

1975 • 23 citations

Distribution of chlorpromazine in the gastrointestinal tract of the rat and its effect on absorptive function.

1975 • 11 citations

Difenoxine (R15403), the active metabolite of diphenoxylate (R1132). 1. The excretion and metabolism in rats of difenoxine, the pharmacologically active metabolite of the antidiarrheal agent diphenoxylate.

1972 • 4 citations