2-Substituted derivatives of adenosine and inosine cyclic 3',5'-phosphates. Synthesis, enzymic activity, and analysis of the structural requirements of the binding locale of the 2-substituent on bovine brain protein kinase

van der Waals Volumes and Radii

1964 • 18,329 citations

A New Substituent Constant, π, Derived from Partition Coefficients

1964 • 1,353 citations

Aromatic substituent constants for structure-activity correlations

1973 • 1,189 citations

Multiple cyclic nucleotide phosphodiesterase activities from rat brain

1971 • 1,054 citations

Field and resonance components of substituent effects

1968 • 893 citations

Membrane formation in Tetrahymena pyriformis. 4. Lipid composition and biochemical properties of Tetrahymena pyriformis membrane systems

1971 • 674 citations

Cyclic Nucleotide-dependent Protein Kinases

1970 • 334 citations

Characterization of Cyclic Nucleotide Phosphodiesterases of Rat Tissues

1971 • 297 citations

Chemical synthesis and biological activity of 8-substituted adenosine 3',5'-cyclic monophosphate derivatives

1971 • 217 citations

Steric parameters in drug design. Monoamine oxidase inhibitors and antihistamines

1969 • 177 citations

Analogs of cyclic AMP and cyclic GMP: General methods of synthesis and the relationship of structure to enzymic activity

1974 • 156 citations

Synthesis and biochemical studies of various 8-substituted derivatives of guanosine cyclic-3',5' phosphate, inosine cyclic-3',5' phosphate, and xanthosine cyclic-3',5' phosphate

1973 • 105 citations

Adenosine 3′,5′-Monophosphate Phosphodiesterase: Multiple Molecular Forms

1971 • 105 citations

Proton Magnetic Resonance of Nucleotides. IV. Ribose Conformation

1962 • 75 citations

Induction of hepatic tyrosine aminotransferase in vivo by derivatives of cyclic adenosine 3':5'-monophosphate

1975 • 75 citations

Synthesis and biological activity of some 2' derivatives of adenosine 3',5'-cyclic phosphate

1973 • 73 citations

Characterization of two forms of beef heart cyclic nucleotide phosphodiesterase

1972 • 44 citations

Synthesis and biological activity of several 6-substituted 9-β-D-ribofuranosylpurine 3',5'-cyclic phosphates

1972 • 42 citations

Synthesis and enzymic studies of 5-aminoimidazole and N-1- and N6-substituted adenine ribonucleoside cyclic 3',5'-phosphates prepared from adenosine cyclic 3',5'-phosphate

1973 • 39 citations

New purine ring closure and the synthesis of 2-substituted derivatives of adenosine cyclic 3',5'-phosphate

1974 • 34 citations

Cyclophosphate

1970 • 31 citations

Synthesis and biological activities of cyclic AMP analogs modified in the 1, 2, and 2′-positions

1974 • 29 citations

Cyclophosphates

1971 • 19 citations

Synthesis and biological activity of certain carbamoyl and alkoxycarbonyl derivatives of adenosine 3',5'-cyclic phosphate

1973 • 16 citations