Leishmania donovani Attachment Stimulates PKC‐Mediated Oxidative Events in Bone Marrow‐Derived Macrophages

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.

1988 • 2,865 citations

Biochemistry of Nitric Oxide and Its Redox-Activated Forms

1992 • 2,725 citations

Secretory products of macrophages.

1987 • 2,670 citations

The Cell Biology of Macrophage Activation

1984 • 1,623 citations

Activated macrophages destroy intracellular Leishmania major amastigotes by an L-arginine-dependent killing mechanism.

1990 • 690 citations

Disappearance of Ca2+-sensitive, phospholipid-dependent protein kinase activity in phorbol ester-treated 3T3 cells

1984 • 643 citations

Expression of the nitric oxide synthase gene in mouse macrophages activated for tumor cell killing. Molecular basis for the synergy between interferon-gamma and lipopolysaccharide.

1993 • 623 citations

Studies on the mechanism of phagocytosis. I. Requirements for circumferential attachment of particle-bound ligands to specific receptors on the macrophage plasma membrane.

1975 • 595 citations

Decrease in cytosolic calcium/phospholipid-dependent protein kinase activity following phorbol ester treatment of EL4 thymoma cells.

1982 • 417 citations

Signal transduction in the mammalian cell during bacterial attachment and entry

1993 • 364 citations

Macrophage Tumor Killing: Influence of the Local Environment

1977 • 341 citations

Signal transduction between enteropathogenic Escherichia coli (EPEC) and epithelial cells: EPEC induces tyrosine phosphorylation of host cell proteins to initiate cytoskeletal rearrangement and bacterial uptake.

1992 • 328 citations

Studies on the mechanism of phagocytosis. II. The interaction of macrophages with anti-immunoglobulin IgG-coated bone marrow-derived lymphocytes.

1976 • 296 citations

Macrophage Activation for Tumor Cytotoxicity: Development of Macrophage Cytotoxic Activity Requires Completion of A Sequence of Short-Lived Intermediary Reactions

1978 • 252 citations

Developmental changes in the glycosylated phosphatidylinositols of Leishmania donovani. Characterization of the promastigote and amastigote glycolipids

1991 • 235 citations

Comparison of protein kinase C functional assays to clarify mechanisms of inhibitor action

1988 • 190 citations

Functional characterization of a stable, noncytolytic stage of macrophage activation in tumors.

1977 • 187 citations

Roles of CR3 and mannose receptors in the attachment and ingestion of Leishmania donovani by human mononuclear phagocytes

1988 • 165 citations

Bacterial entry into eukaryotic cells

1991 • 161 citations

Effect of in vivo inhibition of nitric oxide production in murine leishmaniasis.

1993 • 153 citations

Inhibition of macrophage protein kinase C-mediated protein phosphorylation by Leishmania donovani lipophosphoglycan.

1992 • 147 citations

Defective stimulus-response coupling in human monocytes infected with Leishmania donovani is associated with altered activation and translocation of protein kinase C.

1992 • 134 citations

Inhibitory effects on protein kinase C activity by lipophosphoglycan fragments and glycosylphosphatidylinositol antigens of the protozoan parasite Leishmania

1989 • 131 citations

Immunoglobulin-mediated phagocytosis by human monocytes requires protein kinase C activation. Evidence for protein kinase C translocation to phagosomes.

1992 • 123 citations

Leishmania and the macrophage: a marriage of inconvenience

1989 • 117 citations

The role of protein kinase C in the induction of nitric oxide synthesis by murine macrophages

1992 • 110 citations

Impairment of the oxidative metabolism of mouse peritoneal macrophages by intracellular Leishmania spp

1987 • 107 citations

Kinetics of gamma interferon binding and induction of major histocompatibility complex class II mRNA in Leishmania-infected macrophages.

1988 • 103 citations

Modulation of in vitro monocyte cytokine responses to Leishmania donovani. Interferon-gamma prevents parasite-induced inhibition of interleukin 1 production and primes monocytes to respond to Leishmania by producing both tumor necrosis factor-alpha and interleukin 1.

1990 • 102 citations

Treatment of alveolar macrophages with cytochalasin D inhibits uptake and subsequent growth of Legionella pneumophila

1986 • 101 citations

Stimulus-response coupling in monocytes infected with Leishmania. Attenuation of calcium transients is related to defective agonist-induced accumulation of inositol phosphates.

1992 • 90 citations

Properties of protein kinase C isoforms (beta II, epsilon, and zeta) in a macrophage cell line (J774) and their roles in LPS-induced nitric oxide production.

1994 • 89 citations

c-fos and tumor necrosis factor gene expression in Leishmania donovani-infected macrophages.

1989 • 87 citations

The role of nitrogen oxides as effector molecules of parasite killing

1990 • 72 citations

Alteration of Leishmania donovani infection levels by selective impairment of macrophage signal transduction.

1993 • 64 citations

The production of tumor necrosis factor by mouse bone marrow-derived macrophages in response to bacterial lipopolysaccharide and a chemically synthesized monosaccharide precursor.

1987 • 55 citations

Studies on the molecular mechanisms of human neutrophil Fc receptor-mediated phagocytosis. Evidence that a distinct pathway for activation of the respiratory burst results in reactive oxygen metabolite-dependent amplification of ingestion.

1990 • 51 citations

Translocation of protein kinase C in human polymorphonuclear neutrophils. Regulation by cytosolic Ca2(+)-independent and Ca2(+)-dependent mechanisms.

1990 • 51 citations

Measurement of phorbol ester receptors in intact cells and subcellular fractions

1987 • 51 citations

Down-regulation of mannose receptors on macrophages after infection with Leishmania donovani

1991 • 47 citations

Cell Biology of Host‐Parasite Membrane Interactions in Leishmaniasis

1983 • 45 citations

Staurosporine, a potent protein kinase C inhibitor, fails to inhibit 12-O-tetradecanoylphorbol-13-acetate-caused ornithine decarboxylase induction in isolated mouse epidermal cells

1987 • 45 citations

Extracellular adenosine nucleotides stimulate protein kinase C activity and human neutrophil activation.

1990 • 43 citations

Activation of murine macrophage cell lines. Possible involvement of protein kinases in stimulation of superoxide production.

1984 • 38 citations

Effects of macrophage colony-stimulating factor and phorbol myristate acetate on 2-<scp>d</scp>-deoxyglucose transport and superoxide production in rat peritoneal macrophages

1991 • 32 citations

Macrophage-Directed Delivery of Doxorubicin Conjugated to Neoglycoprotein Using Leishmaniasis as the Model Disease

1993 • 28 citations

A soluble factor produced by inoculation of human monocytes with Leishmania donovani promastigotes suppresses IFN-gamma-dependent monocyte activation.

1990 • 15 citations

Suppression of macrophage lysosomal enzymes after Leishmania donovani infection

1989 • 13 citations

Glucose- and phorbol myristate acetate-stimulated oxygen consumption and superoxide production in rat peritoneal macrophages is inhibited by dexamethasone

1993 • 10 citations