Induction of drug metabolizing enzyme system in the liver

Spectral studies of drug interaction with hepatic microsomal cytochrome.

1967 • 1,126 citations

Studies on the Synthesis and Degradation of Proteins of the Endoplasmic Reticulum of Rat Liver

1969 • 538 citations

PHENOBARBITAL-INDUCED SYNTHESIS OF THE MICROSOMAL DRUG-METABOLIZING ENZYME SYSTEM AND ITS RELATIONSHIP TO THE PROLIFERATION OF ENDOPLASMIC MEMBRANES

1965 • 531 citations

Adaptive increases in drug-metabolizing enzymes induced by phenobarbital and other drugs.

1960 • 511 citations

Turnover of Constituents of the Endoplasmic Reticulum Membranes of Rat Hepatocytes

1967 • 484 citations

Substrate-Induced Synthesis And Other Properties Of Benzpyrene Hydroxylase In Rat Liver

1957 • 475 citations

Microsomes and drug oxidation

1969 • 451 citations

Drug-Induced Changes in the Liver Endoplasmic Reticulum: Association with Drug-Metabolizing Enzymes

1963 • 413 citations

The metabolism of methylated aminoazo dyes. V. Evidence for induction of enzyme synthesis in the rat by 3-methylcholanthrene.

1956 • 393 citations

EFFECT OF DRUGS ON THE FORMATION OF SMOOTH ENDOPLASMIC RETICULUM AND DRUG‐METABOLIZING ENZYMES

1965 • 381 citations

Biochemistry of Drug Oxidation and Reduction by Enzymes in Hepatic Endoplasmic Reticulum

1966 • 357 citations

Drug interaction with hepatic microsomal cytochrome.

1966 • 335 citations

ENZYMATIC DEALKYLATION OF AMINOPYRINE (PYRAMIDON) AND OTHER ALKYLAMINES

1955 • 290 citations

Studies on the rate of reduction of hepatic microsomal cytochrome P-450 by reduced nicotinamide adenine dinucleotide phosphate: effect of drug substrates.

1969 • 275 citations

Enhancement of Glucuronide-Conjugating Capacity in a Hyperbilirubinemic Infant Due to Apparent Enzyme Induction by Phenobarbital

1966 • 260 citations

Ethanol Increases Hepatic Smooth Endoplasmic Reticulum and Drug-Metabolizing Enzymes

1968 • 247 citations

Drug interactions in man

1965 • 235 citations

Cytochrome P-450 of liver microsomes—One pigment or many

1968 • 224 citations

Effects of Phenobarbital on the Synthesis and Degradation of the Protein Components of Rat Liver Microsomal Membranes

1969 • 223 citations

Hormones and Resistance

1971 • 223 citations

Enzyminduktion und Vermehrung von endoplasmatischem Reticulum in der Leberzelle w�hrend der Behandlung mit Phenobarbital (Luminal)

1963 • 221 citations

The rate of decline of diphenylhydantoin in human plasma

1970 • 213 citations

MORPHOLOGICAL CHANGES IN THE LIVER ACCOMPANYING STIMULATION OF MICROSOMAL DRUG METABOLIZING ENZYME ACTIVITY BY PHENOBARBITAL, CHLORDANE, BENZPYRENE OR METHYL-CHOLANTHRENE IN RATS.

1965 • 210 citations

The fate of pentobarbital in man and dog and a method for its estimation in biological material.

1953 • 205 citations

THE ENZYMATIC DEAMINATION OF AMPHETAMINE (BENZEDRINE)

1955 • 204 citations

Effects of Acute and Chronic DDT Administration on Hepatic Microsomal Drug Metabolism in the Rat.

1963 • 193 citations

THE LIGHT REVERSIBLE CARBON MONOXIDE INHIBITION OF THE STEROID C21-HYDROXYLASE SYSTEM OF THE ADRENAL CORTEX.

1963 • 189 citations

Quantitative measurement of induction of hepatic microsomal enzymes by various dietary levels of DDT and toxaphene in rats

1966 • 180 citations

THE STIMULATORY EFFECT OF 3-METHYLCHOLANTHRENE ON BENZPYRENE HYDROXYLASE ACTIVITY IN SEVERAL RAT TISSUES: INHIBITION BY ACTINOMYCIN D AND PUROMYCIN.

1964 • 177 citations

Function of cytochrome P-450 of microsomes.

1965 • 175 citations

Induction of Microsomal Enzyme Synthesis by Polycyclic Aromatic Hydrocarbons of Different Molecular Sizes

1961 • 166 citations

Substrate-induced synthesis of the hydroxylating enzyme system of liver microsomes.

1965 • 152 citations

The Biosynthesis of Glucuronides

1966 • 146 citations

Stimulatory effects of chlordane on hepatic microsomal drug metabolism in the rat

1963 • 146 citations

Der beschleunigte Abbau von Pharmaka in den Lebermikrosomen unter dem Einflu� von Luminal

1959 • 145 citations

The influence of phenobarbital on the turnover of hepatic microsomal cytochrome b5 and cytochrome P-450 hemes in the rat

1970 • 129 citations

Induction and inhibition of hepatic microsomal and mitochondrial enzymes by ethanol.

1970 • 129 citations

Liver tumor inhibition and adrenal histologic responses in rats to which 3'-methyl-4-dimethylaminoazobenzene and 20-methylcholanthrene were simultaneously administered.

1952 • 126 citations

Sex differences in drug metabolism by rat liver microsomes.

1967 • 122 citations

The metabolism of methylated aminoazo dyes. VI. Intracellular distribution and properties of the demethylase system.

1957 • 121 citations

EFFECTS OF PHENOTHIAZINES ON PROTECTIVE SYSTEMS AGAINST POLYCYCLIC HYDROCARBONS.

1965 • 116 citations

APPLICATION OF DRUG METABOLISM TO DRUG TOXICITY STUDIES

1965 • 113 citations

An Effect of o,p′-DDD on the Extra-adrenal Metabolism of Cortisol in Man

1964 • 112 citations

Hormones and Resistance

1971 • 110 citations

Species and sex differences in electron transport systems in liver microsomes and their relationship to ethylmorphine demethylation

1969 • 108 citations

Metabolism of Drugs and Other Foreign Compounds by Enzymatic Mechanisms

1963 • 104 citations

Enzyme Induction in Man caused by Smoking

1967 • 103 citations

The Hydroxylation of the Carcinogen 2-Acetylaminofluorene by Rat Liver: Stimulation by Pretreatment in Vivo with 3-Methylcholanthrene

1960 • 98 citations

STIMULATORY EFFECT OF CHRONIC DRUG ADMINISTRATION ON DRUG‐METABOLIZING ENZYMES IN LIVER MICROSOMES

1963 • 95 citations

Light and electron microscopy of dichlorodiphenyltrichloroethane (DDT) poisoning in the rat liver.

1966 • 90 citations

Effects of norethynodrel and progesterone on hepatic microsomal drug-metabolizing enzyme systems

1966 • 88 citations

The Turnover of Microsomal Protein in the Livers of Phenobarbital-treated Mice

1966 • 87 citations

Studies on the mechanism of action of mammalian hepatic azoreductase—II

1967 • 87 citations

Drug metabolism in ethanol induced fatty liver

1970 • 78 citations

Induction of liver microsomal cortisol 6β-hydroxylase by diphenylhydantoin or phenobarbital: An explanation for the increased excretion of 6-hydroxycortisol in humans treated with these drugs

1965 • 78 citations

Induction of increased meprobamate metabolism in rats pretreated with some neurotropic drugs

1962 • 77 citations

Ueber die Ursachen der Gewöhnung an Morphin

1900 • 76 citations

Studies on the mechanism of drug-induced microsomal enzyme activities. V. Phenobarbital stimulation of endogenous messenger RNA and polyuridylic acid-directed L-[14C]-phenylalanine incorporation.

1966 • 74 citations

Accelerated aminopyrine metabolism in human subjects pretreated with phenylbutazone

1962 • 73 citations

Die Beschleunigung des Evipanabbaues unter der Wirkung von Barbituraten

1958 • 69 citations

Inhibition of microsomal drug metabolic pathways by chloramphenicol

1962 • 68 citations

Griseofulvin-Warfarin Antagonism

1967 • 67 citations

The effect of anabolic steroids on drug metabolism by microsomal enzymes in rat liver.

1962 • 67 citations

The effect of beta-diethylaminoethyl-diphenylpropylacetate hydrochloride (SKF No. 525-A) on hexobarbital.

1954 • 64 citations

461 Drugs as activators of drug enzymes

1961 • 62 citations

Increased Hepatic Microsomal Activity Induced by Spironolactone and Other Steroids

1969 • 61 citations

Stimulatory effect of chlorcyclizine on barbiturate metabolism.

1961 • 61 citations

STUDIES UPON THE SEX-DIFFERENCE IN RATS IN TOLERANCE TO CERTAIN BARBITURATES AND TO NICOTINE

1937 • 61 citations

Metabolism and tolerance studies with chlordiazepoxide-2-14C in the rat

1966 • 59 citations

Stimulatory effect of N-phenylbarbital (phetharbital) on cortisol hydroxylation in man

1968 • 59 citations

The effect of chloral hydrate on bishydroxycoumarin metabolism; a fatal outcome.

1966 • 57 citations

The influence of pregnenolone-16α-carbonitrile on hepatic mixed-function oxygenases

1971 • 56 citations

Evipan, ein neuartiges Einschlafmittel

1932 • 56 citations

Reaction of drugs with microsomal liver hydroxylase: Its influence on drug action

1968 • 55 citations

Lebervergr��erung durch Fremdstoffe

1966 • 55 citations

Teleologisches Denken

1951 • 55 citations

Implication of the Conjugation of Drugs and Other Exogenous Compounds

1966 • 51 citations

INCREASE OF PENTOBARBITONE METABOLISM INDUCED IN RATS PRETREATED WITH SOME CENTRALLY ACTING COMPOUNDS

1962 • 48 citations

Regulation of δ‐Aminolevulinic Acid Synthetase by Drugs and Steroids in vivo and in Isolated Perfused Rat Liver

1971 • 45 citations

Increased activity of microsomal strychnine-metabolizing enzyme induced by phenobarbital and other drugs

1962 • 45 citations

THE ROLE OF HEME IN THE SYNTHESIS AND REPRESSION OF MICROSOMAL PROTEIN

1969 • 45 citations

Studies on the Metabolism of Meprobamate

1963 • 41 citations

Suppression of hepatic ribonuclease during phenobarbital stimulation of drug metabolism

1970 • 40 citations

Die Aktivierung der Entgiftung in den Lebermikrosomen w�hrend der Gew�hnung

1958 • 40 citations

Stimulation by o,p′-DDD of cortisol metabolism in the guinea pig

1964 • 38 citations

The Effect of Chloral Hydrate on Bishydroxycoumarin Metabolism

1966 • 38 citations

The Role of Cytochrome P-450 in Microsomal Mixed Function Oxidation Reactions

1968 • 36 citations

The Fate of Drugs in the Organism

1965 • 36 citations

Effect of clofibrate and 1-methyl-4-piperidyl bis (p-chlorophenoxy) acetate (Sandoz 42–348) on steroid and drug metabolism by rat liver microsomes

1970 • 35 citations

Alteration of enzyme activity in rat liver following the acute and chronic administration of nicotine

1970 • 35 citations

Aktivierung von Mikrosomenenzymen durch Hexachlorcyclohexan-Isomere. Ihr Einflu� auf die Scillirosidvergiftung der Ratte

1964 • 35 citations

Stimulatory effect of nicotine on the metabolism of meprobamate

1966 • 34 citations

Perazine, chlorpromazine and imipramine as inducers of microsomal drug metabolism

1972 • 33 citations

Die Wirkung der Nebennierenrinde auf den Abbau von Pharmaka in den Lebermikrosomen

1958 • 33 citations

Die Verst�rkung der Abbaugeschwindigkeit von Evipan durch Glykocorticoide

1958 • 32 citations

Studies on P-450. III. On the Absorption Spectrum of P-450 in Rabbit Liver Microsomes

1967 • 32 citations

Dimethyl Sulfoxide: Interactions with Aromatic Hydrocarbons

1968 • 32 citations

Effect of ethionine and carbon tetrachloride on urethan and phenobarbital induced changes in hexobarbital action.

1961 • 32 citations

Induced Increase of Meprobamate Metabolism in Rats Treated with Phenobarbital or Phenaglycodol

1960 • 31 citations

A possible role of liver microsomal alkaline ribonuclease in the stimulation of oxidative drug metabolism by phenobarbital, chlordane and chlorophenothane (DDT)

1971 • 29 citations

The effects of oestrogens and progestins on the response of mice to barbiturates

1969 • 29 citations

Ribonucleic acid polymerase activity in liver nuclei from rats pretreated with 3-methylcholanthrene.

1966 • 27 citations

NICOTINE AND SOME CARCINOGENS IN SPECIAL REFERENCE TO THE HEPATIC DRUG-METABOLIZING ENZYMES

1966 • 27 citations

Ultrastructural changes induced by pregnenolone nitrile in the rat liver

1970 • 25 citations

Kumulation und Elimination von Phenobarbital

1962 • 25 citations

The influence of steroids on drug metabolism in the mouse.

1966 • 23 citations

Morphological and Biochemical Changes in Rat Liver during the Early Stages of Ethyl Chlorophenoxyisobutyrate Administration

1969 • 21 citations

463 Physiological impairment of drug metabolism

1961 • 21 citations

Systemic Fat Embolism Following Acute Primary Osteomyelitis

1967 • 18 citations

Die Beschleunigung von enzymatischen Oxydationen in den Lebermikrosomen unter dem Einflu� von Barbituraten

1959 • 18 citations

Studies on the mechanism of meprobamate tolerance in the rat.

1962 • 18 citations

THE EFFECT OF NIKETHAMIDE ON THE METABOLISM OF PENTOBARBITAL BY LIVER MICROSOMES OF THE RAT

1961 • 17 citations

[THE BIOCHEMICAL INTERPRETATION OF HYPNOTIC ADDICTION].

1964 • 17 citations

Autoregulation of the Extracellular Volume

1970 • 17 citations

The influence of lynestrenol on the rate of metabolism of phenobarbital, phenytoin and hexobarbital in mice

1969 • 16 citations

Pharmaco-chemical interrelations among catatoxic steroids.

1970 • 15 citations

TOXICITY OF STRYCHNINE FOR MALE AND FEMALE RATS OF DIFFERENT AGES

1936 • 15 citations

THE RAT-POISONING SUBSTANCE IN RED SQUILLS

1927 • 14 citations

The mechanism of tolerance to thiopental in mice.

1949 • 13 citations

Die Wirkung von DDT und Phenobarbital auf mikrosomale hydroxylierende Cytochrome

1966 • 12 citations

Beeinflussung der Entgiftungszeiten von Avertin und Pentothal-Natrium an der nebennierenlosen Ratte durch Nebennieren-Rindenhormon (Pentothal-Natriumtest)

1949 • 11 citations

Untersuchungen �ber den Mechanismus der narkoseverk�rzenden Wirkung von Monoaminoxydase-Hemmstoffen

1962 • 9 citations

Induction of microsomal hydroxylase: involvement of a second factor besides cytochrome P-450.

1968 • 8 citations

Interferenz von Diazepam und Pentobarbital an der Ratte und am Menschen

1969 • 8 citations

THE EFFECT OF THE REPEATED ADMINISTRATION OF DIETHYL BARBITURIC ACID AND OF CYCLO-HEXENYL-ETHYL BARBITURIC ACID

1929 • 7 citations

Effect of hypophysectomy on pregnenolone-16?-carbonitrile-induced ultrastructural changes in rat liver

1971 • 7 citations

Suppression of synthesis of RNA present in microsomal membranes after administration of phenobarbital

1971 • 7 citations

Rat hepatocyte peroxisomes: Ultrastructural alterations following cessation of chronic dietary clofibrate administration

1969 • 5 citations

Negative Resistance in CdS Single Crystal

1966 • 5 citations

ATROPINE AND SYNTROPAN A COMPARATIVE STUDY

1937 • 3 citations

Die Aktivierung des Arzneimittelabbaues durch Pharmaka

1961 • 1 citations