Oblimersen Sodium (Genasense bcl-2 Antisense Oligonucleotide)

Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

2001 • 3,867 citations

The Bcl2 family: regulators of the cellular life-or-death switch

2002 • 3,782 citations

BCL-2 family members and the mitochondria in apoptosis

1999 • 3,657 citations

Bcl-2 and the regulation of programmed cell death

1994 • 2,346 citations

Apoptosis

2002 • 2,190 citations

Involvement of the bcl -2 Gene in Human Follicular Lymphoma

1985 • 1,797 citations

A matter of life and death

2002 • 1,251 citations

Mechanisms of Apoptosis

2000 • 1,249 citations

Dysregulation of Apoptosis in Cancer

1999 • 983 citations

Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line

1993 • 898 citations

Requirement for Caspase-2 in Stress-Induced Apoptosis Before Mitochondrial Permeabilization

2002 • 727 citations

From bench to clinic with apoptosis-based therapeutic agents

2000 • 703 citations

BCL-2 antisense therapy in patients with non-Hodgkin lymphoma

1997 • 502 citations

Chemosensitisation of malignant melanoma by BCL2 antisense therapy

2000 • 487 citations

Oblimersen Bcl-2 Antisense: Facilitating Apoptosis in Anticancer Treatment

2002 • 278 citations

Genetic analysis of chemoresistance in primary murine lymphomas

2000 • 276 citations

Antisense Oligonucleotides: Promise and Reality

2001 • 240 citations

Induction of Apoptosis in Small-Cell Lung Cancer Cells by an Antisense Oligodeoxynucleotide Targeting the Bcl-2 Coding Sequence

1997 • 221 citations

Phase 1 and pharmacodynamic studies of G3139, a Bcl-2 antisense oligonucleotide, in combination with chemotherapy in refractory or relapsed acute leukemia

2002 • 219 citations

Nucleic Acid Therapeutics: State of the Art and Future Prospects

1998 • 215 citations

Role of NF-κB in the Rescue of Multiple Myeloma Cells From Glucocorticoid-Induced Apoptosis by Bcl-2

1999 • 202 citations

Bcl-2 protein: a prognostic factor inversely correlated to p53 in non-small-cell lung cancer

1995 • 201 citations

Reversal of Chemoresistance of Lymphoma Cells by Antisense-Mediated Reduction ofbcl-2 Gene Expression

1994 • 190 citations

Phase I Study of G3139, a bcl-2 Antisense Oligonucleotide, Combined With Carboplatin and Etoposide in Patients With Small-Cell Lung Cancer

2004 • 167 citations

A pilot trial of G3139, a bcl-2 antisense oligonucleotide,and paclitaxel in patients with chemorefractory small-cell lung cancer

2002 • 156 citations

Synergistic cytotoxicity of bcl-2 antisense oligodeoxynucleotides and etoposide, doxorubicin and cisplatin on small-cell lung cancer cell lines

1998 • 145 citations

Chemosensitization of myeloma plasma cells by an antisense-mediated downregulation of Bcl-2 protein

2003 • 77 citations

Bcl-2 overexpression is associated with resistance to dexamethasone, but not melphalan, in multiple myeloma cells.

1998 • 60 citations

Expression of the Apoptosis suppressing protein bcl-2 in prostatic adenocarcinoma is related to tumor malignancy

1997 • 45 citations

Antisense bcl-2 treatment increases programmed cell death in non-small cell lung cancer cell lines

1999 • 43 citations

Bcl-2 protein and prognosis in patients with potentially curable non-small-cell lung cancer

1998 • 30 citations