Unmasking a new recognition signal for O-linked glycosylation in the chorionic gonadotropin β subunit

Glycoprotein Hormones: Structure and Function

1981 • 2,296 citations

Crystal structure of human chorionic gonadotropin

1994 • 936 citations

Concepts and Principles of O-Linked Glycosylation

1998 • 730 citations

Glycoproteins

1972 • 582 citations

Structure of human chorionic gonadotropin at 2.6 å resolution from MAD analysis of the selenomethionyl protein

1994 • 482 citations

Comparison of O-Linked Carbohydrate Chains in MUC-1 Mucin from Normal Breast Epithelial Cell Lines and Breast Carcinoma Cell Lines:

1996 • 354 citations

Reversible defects in O-linked glycosylation and LDL receptor expression in a UDP-GalUDP-GalNAc 4-epimerase deficient mutant

1986 • 334 citations

Amino acid distributions around O-linked glycosylation sites

1991 • 278 citations

Design of a long-acting follitropin agonist by fusing the C-terminal sequence of the chorionic gonadotropin beta subunit to the follitropin beta subunit.

1992 • 273 citations

O-GLYCBASE version 4.0: a revised database of O-glycosylated proteins

1999 • 270 citations

Translocation across golgi vesicle membranes: A CHO glycosylation mutant deficient in CMP-sialic acid transport

1984 • 266 citations

Structure and location of the O-glycosidic carbohydrate units of human chorionic gonadotropin.

1979 • 215 citations

The role of the asparagine-linked oligosaccharides of the alpha subunit in the secretion and assembly of human chorionic gonadotrophin.

1988 • 203 citations

The Biological Role of the Carboxyl-Terminal Extension of Human Chorionic Gonadotroin β-Subunit

1990 • 187 citations

The specificity of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase as inferred from a database of in vivo substrates and from the in vitro glycosylation of proteins and peptides

1993 • 173 citations

Carbohydrate-peptide linkage in glycoproteins

1976 • 172 citations

Database Analysis of O-Glycosylation Sites in Proteins

2001 • 136 citations

Isolation and amino acid sequence of COOH-terminal fragments from the beta subunit of human choriogonadotropin.

1977 • 122 citations

Molecular basis for the species selectivity of the substance P antagonist CP-96,345.

1993 • 118 citations

Biosynthesis of a biologically active single peptide chain containing the human common alpha and chorionic gonadotropin beta subunits in tandem.

1995 • 115 citations

The influence of flanking sequence on the O-glycosylation of threonine in vitro.

1992 • 110 citations

Effects of preventing O-glycosylation on the secretion of human chorionic gonadotropin in Chinese hamster ovary cells.

1987 • 102 citations

Enhanced stimulation of follicle maturation and ovulatory potential by long acting follicle-stimulating hormone agonists with extended carboxyl-terminal peptides.

1992 • 98 citations

The occurrence in proteins of the tripeptides Asn-X-Ser and Asn-X-Thr and of bound carbohydrate

1970 • 87 citations

Comparative study of the mucin-type sugar chains of human chorionic gonadotropin present in the urine of patients with trophoblastic diseases and healthy pregnant women.

1988 • 82 citations

Influence of quaternary structure on glycosylation. Differential subunit association affects the site-specific glycosylation of the common beta-chain from Mac-1 and LFA-1.

1986 • 74 citations

Enzymic O-glycosylation of synthetic peptides from sequences in basic myelin protein

1979 • 67 citations

Human chorionic gonadotropin. Amino acid sequence of the hormone-specific COOH-terminal region.

1977 • 65 citations

Recombinant thyrotropin containing a beta-subunit chimera with the human chorionic gonadotropin-beta carboxy-terminus is biologically active, with a prolonged plasma half-life: role of carbohydrate in bioactivity and metabolic clearance.

1995 • 65 citations

Charge Distribution of Flanking Amino Acids Influences O-Glycan Acquisition in Vivo

1996 • 64 citations

Complexity in O-linked oligosaccharide biosynthesis engendered by multiple polypeptide N-acetylgalactosaminyltransferases

1996 • 62 citations

The acceptor substrate specificity of porcine submaxillary UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase is dependent on the amino acid sequences adjacent to serine and threonine residues.

1993 • 61 citations

Localisation and Importance of the Sugar Part of Human Casein

1980 • 57 citations

Mutagenesis and chimeric genes define determinants in the beta subunits of human chorionic gonadotropin and lutropin for secretion and assembly.

1989 • 57 citations

The structures of the serine-linked sugar chains on human chorionic gonadotropin

1985 • 55 citations

Specificity of O-glycosylation by bovine colostrum UDP-GalNAc: polypeptide ?-N-acetylgalactosaminyltransferase using synthetic glycopeptide substrates

1996 • 54 citations

Mass Spectrometric Characterization of the β-Subunit of Human Chorionic Gonadotropin

1997 • 54 citations

Presence of terminal N-acetylgalactosamine residues in subregions of the endoplasmic reticulum is influenced by cell differentiation in culture.

1991 • 47 citations

Site-Directed Mutagenesis of the Human Chorionic Gonadotropin β-Subunit: Bioactivity of a Heterologous Hormone, Bovine α-Human des-(122–145)β

1989 • 43 citations

Structural Requirements for Addition of O-Linked Carbohydrate to Recombinant Erythropoietin

1994 • 39 citations

Genetic Fusion of an α-Subunit Gene to the Follicle-Stimulating Hormone and Chorionic Gonadotropin-β Subunit Genes: Production of a Bifunctional Protein

1999 • 34 citations

Evolution of Lutropin to Chorionic Gonadotropin Generates a Specific Routing Signal for Apical Release in Vivo

2002 • 33 citations

Enhanced stimulation of follicle maturation and ovulatory potential by long acting follicle-stimulating hormone agonists with extended carboxyl-terminal peptides

1992 • 33 citations

Characterization of the O-Glycosylation Sites in the Chorionic Gonadotropin β Subunit in Vivo Using Site-directed Mutagenesis and Gene Transfer

1996 • 32 citations

The carbohydrate chains of the β subunit of human chorionic gonadotropin produced by the choriocarcinoma cell line BeWo

1992 • 29 citations

The carboxy-terminal region of the beta-subunits of luteinizing hormone and chorionic gonadotropin differentially influence secretion and assembly of the heterodimers.

1996 • 28 citations

The Carboxyl-Terminal Region Is a Determinant for the Intracellular Behavior of the Chorionic Gonadotropin β Subunit: Effects on the Processing of the Asn-Linked Oligosaccharides

1998 • 23 citations

Recombinant thyrotropin containing a beta-subunit chimera with the human chorionic gonadotropin-beta carboxy-terminus is biologically active, with a prolonged plasma half-life: role of carbohydrate in bioactivity and metabolic clearance

1995 • 22 citations

O-GLYCBASE Version 3.0: a revised database of O-glycosylated proteins

1998 • 20 citations

The carboxy-terminal region of the beta-subunits of luteinizing hormone and chorionic gonadotropin differentially influence secretion and assembly of the heterodimers

1996 • 10 citations

Genetic Fusion of an -Subunit Gene to the Follicle-Stimulating Hormone and Chorionic Gonadotropin- Subunit Genes: Production of a Bifunctional Protein

1999 • 10 citations

The Carboxyl-Terminal Region Is a Determinant for the Intracellular Behavior of the Chorionic Gonadotropin Subunit: Effects on the Processing of the Asn-Linked Oligosaccharides

1998 • 10 citations