Reversal Effects of Antifungal Drugs on Multidrug Resistance in MDR1-0verexpressing HeLa Cells.

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

1987 • 2,788 citations

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1994 • 2,255 citations

Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P‐glycoprotein: Implications for drug delivery and activity in cancer chemotherapy

1995 • 856 citations

Functional role for the 170- to 180-kDa glycoprotein specific to drug-resistant tumor cells as revealed by monoclonal antibodies.

1986 • 561 citations

Effects of the Antifungal Agents on Oxidative Drug Metabolism

2000 • 506 citations

Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein.

1999 • 457 citations

Role of P-Glycoprotein and Cytochrome P450 3A in Limiting Oral Absorption of Peptides and Peptidomimetics†

1998 • 418 citations

Rhodamine efflux patterns predict P-glycoprotein substrates in the National Cancer Institute drug screen.

1994 • 334 citations

Immunochemical detection of the multidrug resistance-associated protein MRP in human multidrug-resistant tumor cells by monoclonal antibodies.

1994 • 284 citations

Monoclonal antibody JSB‐1 detects a highly conserved epitope on the P‐glycoprotein associated with multi‐drug‐resistance

1988 • 278 citations

P-glycoprotein and cytochrome P-450 3A inhibition: dissociation of inhibitory potencies.

1999 • 250 citations

P-Glycoprotein Substrates and Antagonists Cluster into Two Distinct Groups

1997 • 229 citations

Transport of rhodamine 123, a P-glycoprotein substrate, across rat intestine and Caco-2 cell monolayers in the presence of cytochrome P-450 3A-related compounds.

1999 • 181 citations

Comparative effects of the antimycotic drugs ketoconazole, fluconazole, itraconazole and terbinafine on the metabolism of cyclosporin by human liver microsomes.

1991 • 170 citations

Optimisation of Itraconazole Therapy Using Target Drug Concentrations

1998 • 166 citations

Clinical Pharmacokinetics of Fluconazole in Superficial and Systemic Mycoses

1997 • 146 citations

Ketoconazole Effectively Reverses Multidrug Resistance in Highly Resistant KB Cells

1994 • 85 citations

Inhibitory potencies of 1,4-dihydropyridine calcium antagonists to P-glycoprotein-mediated transport: comparison with the effects on CYP3A4.

2000 • 81 citations

Reversal of daunorubicin resistance in P388/ADR cells by itraconazole.

1991 • 54 citations

Potentiation of 5-Fluorouracil, Chromomycin A3, and Bleomycin by Amphotericin B or Polymyxin B in Transformed Fibroblastic Cells

1973 • 34 citations

Reversal effect of itraconazole on adriamycin and etoposide resistance in human leukemia cells

1996 • 33 citations

Imidazole-resistant phenotype and virus transformation in cultured rat cells.

1984 • 12 citations

Differential effect of imidazole antibiotics on untransformed and virus-transformed rat cell lines.

1982 • 7 citations

Nicardipine and Itraconazole Inhibited Transcellular Transport of Digoxin

2000 • 6 citations

Reversal effect of itraconazole on adriamycin and etoposide resistance in human leukemia cells

1996 • 3 citations