A general method of analysis of ligand-macromolecule equilibria using a spectroscopic signal from the ligand to monitor binding. Application to Escherichia coli single-strand binding protein-nucleic acid interactions

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

1949 • 19,979 citations

Theoretical aspects of DNA-protein interactions: Co-operative and non-co-operative binding of large ligands to a one-dimensional homogeneous lattice

1974 • 2,905 citations

Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis

1981 • 2,828 citations

DNAase footprinting a simple method for the detection of protein-DNA binding specificity

1978 • 2,092 citations

A gel electrophoresis method for quantifying the binding of proteins to specific DNA regions: application to components of the Escherichia coli lactose operon regulatory system

1981 • 1,991 citations

Thermodynamic analysis of ion effects on the binding and conformational equilibria of proteins and nucleic acids: the roles of ion association or release, screening, and ion effects on water activity

1978 • 1,651 citations

Lac represser-operator interaction

1973 • 699 citations

Two binding modes in Escherichia coli single strand binding protein-single stranded DNA complexes. Modulation by NaCl concentration.

1985 • 363 citations

Interactions of bacteriophage T4-coded gene 32 protein with nucleic acids

1981 • 339 citations

Large-scale overproduction and rapid purification of the Escherichia coli ssb gene product. Expression of the ssb gene under .lambda. PL control

1986 • 244 citations

Studies of the temperature-dependent conformation and phase separation of polyriboadenylic acid solutions at neutral pH

1967 • 229 citations

DNA "melting" proteins. IV. Fluorescence measurements of binding parameters for bacteriophage T4 gene 32-protein to mono-, oligo-, and polynucleotides.

1976 • 192 citations

Escherichia coli single-strand binding protein forms multiple, distinct complexes with single-stranded DNA

1986 • 191 citations

Salt-dependent changes in the DNA binding co-operativity of Escherichia coli single strand binding protein

1986 • 186 citations

Kinetics of Protein-Nucleic Acid Interactions: Use of Salt Effects to Probe Mechanisms of Interactio

1986 • 183 citations

Escherichia coli single-strand binding protein organizes single-stranded DNA in nucleosome-like units.

1982 • 173 citations

Direct measurement of association constants for the binding of Escherichia coli lac repressor to non-operator DNA

1977 • 160 citations

Interactions of bacteriophage T4-coded gene 32 protein with nucleic acids

1981 • 155 citations

On the Specificity of the Binding of the Estradiol Receptor Protein to Deoxyribonucleic Acid

1974 • 144 citations

Visualization of SSB-ssDNA Complexes Active in the Assembly of Stable RecA-DNA Filaments

1984 • 134 citations

Measuring the binding of small molecules to protein from binding-induced alterations of physical-chemical properties

1972 • 120 citations

Nucleic acid binding properties of Escherichia coli ribosomal protein S1

1978 • 109 citations

Fluorescence studies of the complex formation between the gene 5 protein of bacteriophage M13 and polynucleotides

1983 • 88 citations

Physical studies of the interaction between the Escherichia coli DNA binding protein and nucleic acids

1975 • 85 citations

Measurement of binding constants for protein-DNA interactions by DNA-cellulose chromatography

1977 • 74 citations

Cooperative, excluded-site binding and its dynamics for the interaction of gene 5 protein with polynucleotides

1983 • 55 citations

Use of difference boundary sedimentation velocity to investigate nonspecific protein-nucleic acid interactions

1980 • 49 citations

Measurement of macromolecular equilibrium binding constants by a sucrose gradient band sedimentation method. Application to protein-nucleic acid interactions

1979 • 42 citations

Thermodynamics and kinetics of co-operative protein-nucleic acid binding

1983 • 39 citations

A boundary sedimentation velocity method for determining nonspecific nucleic acid-protein interaction binding parameters

1977 • 32 citations

Lambda phage cro repressor

1982 • 29 citations

Optical detection of triplet-state magnetic resonance studies on individual tryptophan residues of serum albumin: correlation between phosphorescence and zero-field splittings

1987 • 10 citations