Semliki Forest Virus Vectors Engineered to Express Higher IL-12 Levels Induce Efficient Elimination of Murine Colon Adenocarcinomas

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A New Generation of Animal Cell Expression Vectors Based on the Semliki Forest Virus Replicon

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The alphaviruses: gene expression, replication, and evolution.

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Inhibition of Angiogenesis In Vivo by Interleukin 12

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An overview of current delivery systems in cancer gene therapy

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Interleukin-12 in anti-tumor immunity and immunotherapy

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Cancer therapy using a self-replicating RNA vaccine

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Two-Helper RNA System for Production of Recombinant Semliki Forest Virus Particles

1999 • 258 citations

Latest development in viral vectors for gene therapy

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Establishment of a cloned line of Lewis lung carcinoma cells adapted to cell culture

1980 • 205 citations

Dendritic Cells Infiltrating Tumors Cotransduced with Granulocyte/Macrophage Colony-Stimulating Factor (Gm-Csf) and Cd40 Ligand Genes Take up and Present Endogenous Tumor-Associated Antigens, and Prime Naive Mice for a Cytotoxic T Lymphocyte Response

1999 • 184 citations

Enhancement of tumor-specific immune response with plasmid DNA replicon vectors.

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Membrane fusion process of Semliki Forest virus. II: Cleavage-dependent reorganization of the spike protein complex controls virus entry.

1992 • 156 citations

Hepatitis C Virus Structural Proteins Impair Dendritic Cell Maturation and Inhibit In Vivo Induction of Cellular Immune Responses

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Systemic tumor targeting and killing by Sindbis viral vectors

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A Significantly Improved Semliki Forest Virus Expression System Based on Translation Enhancer Segments from the Viral Capsid Gene

1994 • 131 citations

Immunization with recombinant Semliki Forest virus induces protection against influenza challenge in mice

1999 • 121 citations

Cancer Immunotherapy Using Sindbis Virus Replicon Particles Encoding a VP22–Antigen Fusion

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Antitumor efficacy of Venezuelan equine encephalitis virus replicon particles encoding mutated HPV16 E6 and E7 genes

2003 • 109 citations

Transfer of the murine interleukin-12 gene in vivo by a Semliki Forest virus vector induces B16 tumor regression through inhibition of tumor blood vessel formation monitored by Doppler ultrasonography

1999 • 108 citations

Regression of colon cancer and induction of antitumor immunity by intratumoral injection of adenovirus expressing interleukin-12

1999 • 94 citations

Alphavirus-Based Vaccines

2014 • 90 citations

Eradication of established HPV16-transformed tumours after immunisation with recombinant Semliki Forest virus expressing a fusion protein of E6 and E7

2003 • 75 citations

Inhibition of human lung carcinoma cell growth by apoptosis induction using Semliki Forest virus recombinant particles

2000 • 70 citations

Improving efficacy of interleukin‐12‐transfected dendritic cells injected into murine colon cancer with anti‐CD137 monoclonal antibodies and alloantigens

2004 • 68 citations

Enhancement of antitumor immune response in glioma models in mice by genetically modified dendritic cells pulsed with Semliki Forest virus—mediated complementary DNA

2001 • 66 citations

Induction of P815 tumor immunity by recombinant Semliki Forest virus expressing the P1A gene

1999 • 65 citations

Recombinant Semliki Forest virus particles encoding the prME or NS1 proteins of louping ill virus protect mice from lethal challenge.

1999 • 64 citations

Immunization strategy against cervical cancer involving an alphavirus vector expressing high levels of a stable fusion protein of human papillomavirus 16 E6 and E7

2002 • 64 citations

Induction of an antitumor immunological response by an intratumoral injection of dendritic cells pulsed with genetically engineered Semliki Forest virus to produce interleukin-18 combined with the systemic administration of interleukin-12

2003 • 61 citations

Induction of therapeutic antitumor antiangiogenesis by intratumoral injection of genetically engineered endostatin-producing Semliki Forest virus

2001 • 61 citations

Construction and immunogenicity in a prime–boost regimen of a Semliki Forest virus-vectored experimental HIV clade A vaccine

2003 • 55 citations

Marked enhancement of antitumor immune responses in mouse brain tumor models by genetically modified dendritic cells producing Semliki Forest virus—mediated interleukin-12

2002 • 53 citations

Expression of Proteins Using Semliki Forest Virus Vectors

1995 • 51 citations

Genetic heterogeneity in the toxicity to systemic adenoviral gene transfer of interleukin-12

2001 • 49 citations

Immunotherapy with recombinant SFV‐replicons expressing the P815A tumor antigen or IL‐12 induces tumor regression

2002 • 47 citations

Genetic immunization against cervical carcinoma: induction of cytotoxic T lymphocyte activity with a recombinant alphavirus vector expressing human papillomavirus type 16 E6 and E7

2000 • 42 citations

Alphavirus-Based Vaccines

2016 • 41 citations

Treatment of rapidly growing K-BALB and CT26 mouse tumours using Semliki Forest virus and its derived vector

2004 • 37 citations

Venezuelan Equine Encephalitis Replicon Immunization Overcomes Intrinsic Tolerance and Elicits Effective Anti-tumor Immunity to the ‘Self’ tumor-associated antigen, neu in a Rat Mammary Tumor Model

2003 • 33 citations

Cytokine Gene Transfer into Dendritic Cells for Cancer Treatment

2002 • 23 citations

Interferon-α and interleukin-12 gene therapy of cancer: interferon-α induces tumor-specific immune responses while interleukin-12 stimulates non-specific killing

2003 • 22 citations

Alphavirus vectors: from protein production to gene therapy

2000 • 10 citations

Anti-ICAM-2 monoclonal antibody synergizes with intratumor gene transfer of interleukin-12 inhibiting activation-induced T-cell death.

2003 • 7 citations