Hydroxyl radical scavengers inhibit TNF-α production in mononuclear cells but not in polymorphonuclear leukocytes

Oxygen toxicity, oxygen radicals, transition metals and disease

1984 • 5,301 citations

Function and Activation of NF-kappaB in the Immune System

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Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases

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Inflammation. Basic principles and clinical correlates

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Antioxidant and redox regulation of gene transcription

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The Pathophysiology of Tumor Necrosis Factors

1992 • 1,880 citations

Nuclear Factor Kb: An Oxidative Stress-Responsive Transcription Factor of Eukaryotic Cells (A Review)

1992 • 1,421 citations

An essential role for free radicals and derived species in signal transduction

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Inflammation, immunoregulation, and inducible nitric oxide synthase

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Production of superoxide radicals and hydrogen peroxide by NADH-ubiquinone reductase and ubiquinol-cytochrome c reductase from beef-heart mitochondria

1977 • 854 citations

Cachectin/tumor necrosis factor: production, distribution, and metabolic fate in vivo.

1985 • 788 citations

Molecular Cloning of the Complementary DNA for Human Tumor Necrosis Factor

1985 • 633 citations

Priming of neutrophils for enhanced release of oxygen metabolites by bacterial lipopolysaccharide. Evidence for increased activity of the superoxide-producing enzyme.

1984 • 612 citations

Gram‐negative endotoxin: an extraordinary lipid with profound effects on eukaryotic signal transduction ¹

1991 • 519 citations

Free radicals and phagocytic cells

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Involvement of reactive oxygen intermediates in cyclooxygenase-2 expression induced by interleukin-1, tumor necrosis factor-alpha, and lipopolysaccharide.

1995 • 477 citations

The role of free radicals in asbestos-induced diseases

1992 • 421 citations

Free radicals in inflammation: second messengers and mediators of tissue destruction

1993 • 404 citations

Release of tumor necrosis factor-alpha from macrophages. Enhancement and suppression are dose-dependently regulated by prostaglandin E2 and cyclic nucleotides.

1988 • 397 citations

Regulation of interleukin 8 gene expression by oxidant stress.

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Activation of the NF-κB Pathway by Inflammatory Stimuli in Human Neutrophils

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Circulating human peripheral blood granulocytes synthesize and secrete tumor necrosis factor alpha.

1990 • 290 citations

Oxygen radicals as second messengers for expression of the monocyte chemoattractant protein, JE/MCP-1, and the monocyte colony-stimulating factor, CSF-1, in response to tumor necrosis factor-alpha and immunoglobulin G. Evidence for involvement of reduced nicotinamide adenine dinucleotide phosphate (NADPH)-dependent oxidase.

1993 • 275 citations

Lipopolysaccharide antagonists

1992 • 243 citations

N-Acetylcysteine and glutathione as inhibitors of tumor necrosis factor production

1992 • 238 citations

Tumor necrosis factor in the pathophysiology of infection and sepsis

1990 • 233 citations

Oxygen radical scavengers selectively inhibit interleukin 8 production in human whole blood.

1992 • 232 citations

THE HABER‐WEISS CYCLE

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Polymorphonuclear leukocyte-mediated cell and tissue injury: Oxygen metabolites and their relations to human disease

1985 • 197 citations

Oxygen radicals, inflammation, and tissue injury

1988 • 179 citations

Regulation of cytokine gene expression by reactive oxygen and reactive nitrogen intermediates

1996 • 150 citations

Release of tumor necrosis factor by human polymorphonuclear leukocytes

1990 • 144 citations

Reactive oxygen species facilitate the in vitro and in vivo lipopolysaccharide-induced release of tumor necrosis factor.

1989 • 141 citations

Iron and reactive oxygen species in the asbestos-induced tumor necrosis factor-alpha response from alveolar macrophages.

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Regulation of T-cell activation and T-cell growth factor (TCGF) production by hydrogen peroxide

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The generation of oxygen radicals: A positive signal for lymphocyte activation

1988 • 80 citations

Uptake of lactoferrin by mononuclear phagocytes inhibits their ability to form hydroxyl radical and protects them from membrane autoperoxidation.

1991 • 61 citations

Concordance of endotoxemia with gram-negative bacteremia in patients with gram-negative sepsis: a meta-analysis

1994 • 60 citations

Effect of NADPH oxidase inhibition on endothelial cell ELAM-1 mRNA expression

1992 • 43 citations

Polymorphonuclear leukocytes: Dedicated professional phagocytes

1983 • 35 citations

The NBT (Nitroblue Tetrazolium) Activity of Neutrophil Granulocytes in Patients with Influenza A Infection

1977 • 27 citations

Extracellular acidic pH modulates oxygen-dependent cytotoxic responses mediated by polymorphonuclear leucocytes and monocytes

1993 • 18 citations