THE PHYSIOLOGY OF PRE‐ECLAMPSIA

Preeclampsia is associated with abnormal expression of adhesion molecules by invasive cytotrophoblasts.

1993 • 552 citations

The role of nitric oxide in the pathogenesis of preeclampsia

1994 • 392 citations

Preeclampsia is associated with a serum factor cytotoxic to human endothelial cells

1988 • 290 citations

Hypertensive Disorders in Pregnancy

1978 • 268 citations

Decreased prostacyclin biosynthesis preceding the clinical manifestation of pregnancy-induced hypertension.

1987 • 256 citations

Preeclampsia: a review of the role of prostaglandins.

1988 • 255 citations

An Epidemiologic Study of Contraception and Preeclampsia

1989 • 254 citations

The effect of placental syncytiotrophoblast microvillous membranes from normal and pre‐eclamptic women on the growth of endothelial cells in vitro

1993 • 232 citations

Reduced umbilical and placental vascular prostacyclin in severe pre-eclampsia

1980 • 224 citations

Hypocalciuria in Preeclampsia

1987 • 206 citations

Thromboxane A2 synthesis in pregnancy-induced hypertension

1990 • 204 citations

Calcium supplementation to prevent hypertensive disorders of pregnancy

1992 • 199 citations

Trophoblast deportation in pre‐eclamptic pregnancy

1991 • 193 citations

Endothelial-derived relaxing factor released by endothelial cells of human umbilical vessels and its impairment in pregnancy-induced hypertension

1991 • 189 citations

Lipid Peroxidation in Pregnancy

1994 • 186 citations

Calcium supplementation reduces the risk of pregnancy‐induced hypertension in an Andes population

1989 • 151 citations

Ultrastructural aspects of preeclampsia

1989 • 136 citations

Capillary Permeability and Extracellular Fluid Volumes in Pregnancy-Induced Hypertension

1989 • 122 citations

Management of Hypertension in Pregnancy: Executive Summary

1993 • 112 citations

Hemodynamic profile of severe pregnancy-induced hypertension

1988 • 112 citations

Genetic control of susceptibility to eclampsia and miscarriage

1988 • 111 citations

Flow Cytometric Detection of Circulating Activated Platelets and Platelet Hyper-Responsiveness in Pre-Eclampsia and Pregnancy

1994 • 105 citations

Abnormal vascular function and morphology in preeclampsia: a study of isolated resistance vessels

1985 • 103 citations

Altered expression of plasminogen activator inhibitor type 1 in placentas from pregnant women with preeclampsia and/or intrauterine fetal growth retardation

1994 • 102 citations

Pre-eclampsia in pregnancies by different fathers: immunological studies.

1975 • 101 citations

AUTACOIDS AND CONTROL OF HUMAN PLACENTAL BLOOD FLOW

1994 • 96 citations

Distribution of cell adhesion molecules in decidua of early human pregnancy. An immunohistochemical study.

1994 • 94 citations

Adverse Interactions Between Pregnancy and a New Model of Systemic Hypertension Produced by Chronic Blockade of Endothelial Derived Relaxing Factor (EDRF) in the Rat

1992 • 93 citations

Extracellular fluid volumes in pregnancy-induced hypertension

1992 • 93 citations

Sera from preeclamptic women increase the content of triglycerides and reduce the release of prostacyclin in cultured endothelial cells

1991 • 91 citations

Left ventricular mechanics in preeclampsia

1991 • 88 citations

Sodium excretion in normal and hypertensive pregnancy: A prospective study

1988 • 87 citations

Mechanisms of vasodilatation in pregnancy: studies of the role of prostaglandins and nitric‐oxide in changes of vascular reactivity in the in situ blood perfused mesentery of pregnant rats

1993 • 86 citations

Renin-Aldosterone Relationships in Pregnancy-Induced Hypertension: An Alternative Viewpoint

1992 • 85 citations

Pre-eclampsia in pregnancies from donor inseminations

1983 • 84 citations

Is genetic susceptibility to pre‐eclampsia conferred by homozygosity for the same single recessive gene in mother and fetus?

1991 • 80 citations

Pre-eclampsia is associated with an increase in trophoblast glycogen content and glycogen synthase activity, similar to that found in hydatidiform moles.

1993 • 76 citations

Relationship Between Nitric Oxide Synthesis and Increase in Systolic Blood Pressure in Women with Hypertension in Pregnancy

1993 • 74 citations

Pre-eclampsia: discordance among identical twins.

1991 • 73 citations

Immunocytochemical localization of neutrophil elastase in term placenta decidua and myometrium in pregnancy‐induced hypertension

1991 • 67 citations

The role of arachidonic acid metabolites in preeclampsia.

1986 • 66 citations

Comparative study of platelet angiotensin II binding and the angiotensin II sensitivity test as predictors of pregnancy-induced hypertension

1992 • 64 citations

Angiotensin II metabolic clearance rate and pressor responses in nonpregnant and pregnant women

1994 • 60 citations

Nitric Oxide Metabolites in Normal Human Pregnancy and Preeclampsia

1995 • 56 citations

Selective effects of preeclamptic sera on human endothelial cell procoagulant protein expression

1991 • 50 citations

Preeclamptic Sera Stimulate Increased Platelet‐Derived Growth Factor mRNA and Protein Expression by Cultured Human Endothelial Cells

1991 • 46 citations

Atrial Natriuretic Factor in Pregnancy-induced Hypertension and Preeclampsia: Increased Plasma Concentrations Possibly Explaining These Hypovolemic States With Paradoxical Hyporeninism

1988 • 44 citations

Immunohistologic demonstration of endothelial disruption in acute atherosis in pre-eclampsia

1993 • 41 citations

Nitric Oxide Excretion in Normal and Hypertensive Pregnancies

1995 • 40 citations

Decrease in cytochrome c oxidase and cytochrome oxidase subunit I messenger RNA levels in preeclamptic pregnancies.

1994 • 40 citations

Preliminary evidence for homoeostatic mechanism regulating endothelin production in pre-eclampsia

1991 • 40 citations

Nitric oxide production by human umbilical vessels in severe pre-eclampsia

1994 • 39 citations

Plasminogen activator of urokinase type and its inhibitor of placental type in hypertensive pregnancies and in intrauterine growth retardation: Possible markers of placental function

1994 • 36 citations

The effects of intravenous angiotensin II upon blood pressure and sodium and urate excretion in human pregnancy

1988 • 34 citations

Magnesium sulfate therapy in preeclampsia is associated with increased urinary cyclic guanosine monophosphate excretion

1992 • 34 citations

Increases in plasma atrial natriuretic peptide concentration antedate clinical evidence of preeclampsia.

1992 • 32 citations

Hypertension in Pregnancy

1986 • 31 citations

Endothelin, a vasoconstrictor important to the uteroplacental circulation in pre-eclampsia

1991 • 30 citations

Placental Production of Nitric Oxide and Endothelin in Normal and Preeclamptic Pregnancies

1994 • 29 citations

Measurement of Individual Plasma Angiotensins in Normal Pregnancy and Pregnancy-Induced Hypertension*

1991 • 26 citations

Partial Characterization of a Novel Growth Factor from the Blood of Women with Preeclampsia*

1990 • 26 citations

Elevated plasma levels of endothelin in pre-eclampsia

1991 • 25 citations

The role of serotonin in the preeclampsia-eclampsia syndrome

1990 • 24 citations

Reduced serum inhibition of platelet-activating factor activity in preeclampsia

1989 • 24 citations

Atrial Natriuretic Peptide and Plasma Volume in Pregnancy-Induced Hypertension

1991 • 24 citations

Stimulation of Active Renin Release in Normal and Hypertensive Pregnancy

1990 • 23 citations

Gross Morphological Brain Differences Between Wistar-Kyoto and Spontaneously Hypertensive Rats.

1980 • 23 citations

Morphologic changes in the renal glomerulus and the juxtaglomerular apparatus in human preeclampsia

1988 • 23 citations

Endothelin Excretion in Hypertensive Pregnancy: Relationship to Glomerular Filtration Rate, Blood Pressure, and Sodium Excretion

1994 • 22 citations

Impaired Renin Stimulation in Pre-Eclampsia

1994 • 21 citations

Ratio between aldosterone and atrial natriuretic peptide in pregnancy

1989 • 20 citations

Stimulation of aldosterone by ACTH in normal and hypertensive pregnancy

1995 • 19 citations

Increases in plasma atrial natriuretic peptide concentration antedate clinical evidence of preeclampsia

1992 • 16 citations

Renin Activation in Normal and Hypertensive Human Pregnancy

1987 • 14 citations

Maternal-Fetal Immunity: Presence of Specific Cellular Hyporesponsiveness and Humoral Suppressor Activity in Normal Pregnancy and Their Absence in Preeclampsia

1983 • 12 citations

Endothelium-derived prostacyclin: effect of serum from women with normal and hypertensive pregnancy

1992 • 12 citations

Platelets in Normal and Hypertensive Pregnancy

1991 • 11 citations

Control of Aldosterone in Normal and Hypertensive Pregnancy: Effects of Metoclopramide

1993 • 11 citations

Possible mechanism of vascular damage in pre-eclampsia.

1994 • 10 citations

Endothelin, a vasoconstrictor important to the uteroplacental circulation in pre-eclampsia

1991 • 10 citations

Calcium and Calciotropic Hormones in Transient Hypertension of Pregnancy Versus Preeclampsia

1994 • 9 citations

Studies on placental inhibition of platelet aggregation: A comparison of human syncytiotrophoblast brush border and basal plasma membranes

1993 • 6 citations

ANF and Head-Out Water Immersion in Normotensive and Essential Hypertensive Pregnant Women

1992 • 5 citations

Limitation of the Alpha-Methylnorepinephrine Hypothesis in the Hypotensive Effect of Alpha-Methyldopa

1989 • 1 citations

20 Endothelium-dependent relaxation in human subcutaneous fat resistance vessels in pre-eclampsia

1991 • 1 citations