Platelet-vessel wall interactions: Implication of 5-hydroxytryptamine. A review

Pharmacology and endogenous roles of prostaglandin endoperoxides, thromboxane A2, and prostacyclin.

1978 • 1,559 citations

STUDIES ON INFLAMMATION

1961 • 1,539 citations

Multiple serotonin receptors: differential binding of [3H]5-hydroxytryptamine, [3H]lysergic acid diethylamide and [3H]spiroperidol.

1979 • 1,321 citations

Arachidonic Acid Metabolites and the Interactions between Platelets and Blood-Vessel Walls

1979 • 1,158 citations

[3H]Ketanserin (R 41 468), a selective 3H-ligand for serotonin2 receptor binding sites. Binding properties, brain distribution, and functional role.

1982 • 1,049 citations

Leukotrienes promote plasma leakage and leukocyte adhesion in postcapillary venules: in vivo effects with relevance to the acute inflammatory response.

1981 • 1,030 citations

Receptor binding profile of R 41 468, A novel antagonist at 5-HT2 receptors

1981 • 848 citations

ENDOTHELIAL CONTRACTION INDUCED BY HISTAMINE-TYPE MEDIATORS

1969 • 841 citations

STUDIES ON INFLAMMATION

1961 • 714 citations

Haemostasis and Thrombosis.

1982 • 688 citations

Platelets in Biology and Pathology

1981 • 644 citations

Vascular effects of ketanserin (R 41 468), a novel antagonist of 5-HT2 serotonergic receptors.

1981 • 511 citations

Plasma levels of beta-thromboglobulin and platelet factor 4 as indices of platelet activation in vivo

1981 • 511 citations

Coronary Arterial Smooth Muscle Contraction by a Substance Released from Platelets: Evidence That It Is Thromboxane A ₂

1976 • 504 citations

Increased platelet aggregation in diabetes mellitus.

1982 • 325 citations

Vascular smooth muscle. II. Pharmacology of normal and hypotensive vessels.

1970 • 322 citations

Simple Method for Quantitation of Enhanced Vascular Permeability

1970 • 271 citations

The Anterior and the Lateral Compartmental Syndrome of the Leg Due to Intensive Use of Muscles

1975 • 262 citations

Thromboxane A₂in Vasotonic Angina Pectoris

1981 • 226 citations

Thromboxane release during pacing-induced angina pectoris: possible vasoconstrictor influence on the coronary vasculature.

1980 • 224 citations

Aspirin-like drugs interfere with arachidonate metabolism by inhibition of the 12-hydroperoxy-5,8,10,14-eicosatetraenoic acid peroxidase activity of the lipoxygenase pathway.

1979 • 206 citations

Elevation of thromboxane B2 levels in patients with classic and variant angina Pectoris.

1981 • 206 citations

Evidence that phospholipid turnover is the signal transducing system coupled to serotonin-S2 receptor sites.

1985 • 206 citations

5-Hydroxytryptamine can mediate endothelium-dependent relaxation of coronary arteries

1983 • 194 citations

ELEVATED β-THROMBOGLOBULIN LEVELS AND CIRCULATING PLATELET AGGREGATES IN DIABETIC MICROANGIOPATHY

1978 • 179 citations

Correlation of arteriographic findings and symptoms in cerebrovascular disease

1980 • 169 citations

Inhibition of 5-hydroxytryptamine-induced and-amplified human platelet aggregation by ketanserin (R 41 468), a selective 5-HT2-receptor antagonist

1982 • 165 citations

PLASMA-THROMBOGLOBULIN CONCENTRATIONS IN DIABETES MELLITUS

1978 • 140 citations

Characterization of Human Platelet Vascular Permeability-Enhancing Activity

1972 • 128 citations

β-Thromboglobulin - a Specific Marker of In-Vivo Platelet Release Reaction

1980 • 124 citations

Response of platelets to tissue injury

1968 • 123 citations

Interaction between 5-hydroxytryptamine and other vasoconstrictor substances in the isolated femoral artery of the rabbit; effect of ketanserin (R 41 468)

1982 • 116 citations

Treatment of raynaud's phenomenon with ketanserin, a selective antagonist of the serotonin₂ (5‐HT₂) receptor

1984 • 116 citations

5‐Hydroxytryptamine in Peripheral Reactions

1983 • 114 citations

NEW RAPID METHOD FOR DIAGNOSIS OF DEEP VENOUS THROMBOSIS

1975 • 112 citations

Prostaglandin Endoperoxide – Thromboxane Synthesis and Dense Granule Secretion as Positive Feedback Loops in the Propagation of Platelet Responses during “The Basic Platelet Reaction”

1977 • 108 citations

Human β-thromboglobulin inhibits PGI2 production and binds to a specific site in bovine aortic endothelial cells

1979 • 108 citations

Serotonin receptor-mediated stimulation of bovine smooth muscle cell prostacyclin synthesis and its modulation by platelet-derived growth factor.

1981 • 106 citations

ABNORMAL PLATELET FUNCTION IN PRE‐ECLAMPSIA

1978 • 106 citations

Increased Vascular permeability produced by human platelet granule cationic extract

1970 • 106 citations

Evidence for functional 5-HT2 receptor sites on human blood platelets

1984 • 102 citations

Prognostic significance of the number of induced ventricular complexes during assessment of therapy for ventricular tachyarrhythmias.

1983 • 97 citations

Release of Permeability Factors from the Blood Platelet

1965 • 96 citations

5-hydroxytryptamine and platelet aggregation.

1983 • 94 citations

Muscle blood flow disturbances produced by simultaneously elevated venous and total muscle tissue pressure

1980 • 94 citations

The subendothelial microfibril and platelet adhesion.

1971 • 93 citations

Intra-arterial Injections of Histamine, Serotonin, or Bradykinin: A Topographic Study of Vascular Leakage

1970 • 91 citations

Hypertension and propranolol therapy: Effect on blood pressure, plasma catecholamines and platelet aggregation

1980 • 89 citations

Raynaud's Disease, Raynaud's Phenomenon, and Serotonin

1960 • 88 citations

Platelet function in hypertension and effect of therapy

1981 • 87 citations

Increased β‐Thromboglobulin in Essential Hypertension: Interactions between Arterial Plasma Adrenaline, Platelet Function and Blood Lipids

1983 • 82 citations

Increased in vivo and in vitro platelet function in type II- and type IV-hyperlipoproteinemia

1979 • 82 citations

Treatment of Raynaud's phenomenon with the 5-HT2-receptor antagonist ketanserin.

1982 • 82 citations

Metabolic functions of the pulmonary circulation.

1982 • 81 citations

Serotonergic Receptor Subtypes and Vascular Reactivity

1984 • 75 citations

Actions of serotonin antagonists on dog coronary artery

1982 • 71 citations

The elusory role of serotonin in vascular function and disease

1983 • 69 citations

Selectivity of Calcium Antagonism and Serotonin Antagonism with Respect to Venous and Arterial Tissues

1981 • 69 citations

Platelet aggregation at sites of minimal endothelial injury. An electron microscopic study.

1968 • 67 citations

Platelet activation in clinical coronary artery disease and spasm

1981 • 66 citations

Further evidence that vascular serotonin receptors are of the 5HT2 type

1983 • 65 citations

Adenosine diphosphate induced platelet aggregation in myocardial infarction and ischemic heart disease

1973 • 65 citations

Rheology of thrombotic processes in flow: The interaction of erythrocytes and thrombocytes subjected to high flow forces1

1981 • 65 citations

Platelet-mediated vascular contractions: Inhibition of the serotonergic component by ketanserin

1982 • 62 citations

Haemostasis and Thrombosis

1982 • 61 citations

Therapeutic Benefits of 5-Hydroxytryptamine Inhibition Following Pulmonary Embolism

1983 • 56 citations

Transient ischemic attacks due to increased platelet aggregation and adhesiveness

1979 • 54 citations

Metabolic functions of the pulmonary circulation.

1982 • 53 citations

Human platelet 5HT receptors: Characterisation and functional association

1980 • 52 citations

Pharmacological Control of Platelet and Red Blood Cell Function in the Microcirculation

1981 • 50 citations

Uptake of serotonin by human platelets and its relevance to CNS involvement in hypertension

1979 • 50 citations

Blood platelets do not provide endoperoxides for vascular prostacyclin production

1979 • 50 citations

Identification of a serotonin type 2 receptor linked to prostacyclin synthesis in vascular smooth muscle cells

1984 • 49 citations

Increased platelet adhesiveness in hypertensive cardiovascular disease

1968 • 48 citations

Thromboxane release in coronary artery disease: Spontaneous versus pacing-induced angina

1984 • 47 citations

The involvement of 5-HT2-receptor sites in the activation of cat platelets

1984 • 45 citations

ACTIONS OF LOCALLY ADMINISTERED ADRENOCEPTOR AGONISTS ON INCREASED PLASMA PROTEIN EXTRAVASATION AND BLOOD FLOW IN GUINEA‐PIG SKIN

1980 • 43 citations

Intraplatelet serotonin and plasma 5-hydroxyindoles in health and disease

1981 • 43 citations

Direct evidence for the contractile capacity of endothelial cells

1981 • 43 citations

Effect of the Ca2+ antagonist lidoflazine on normoxic and anoxic contractions of canine coronary arterial smooth muscle

1980 • 42 citations

Excitatory and inhibitory modulation of intracellular free calcium in human platelets by hormones and drugs

1983 • 40 citations

Plasma exchange and platelet function in Raynaud's phenomenon

1980 • 40 citations

Effects of ketanserin and mepyramine on platelet aggregation and on the uptake of 5-hydroxytryptamine into platelets

1983 • 39 citations

5-hydroxytryptamine and precapillary vessels.

1983 • 38 citations

Platelet-mediated vascular contractions inhibition by flunarizine, a calcium-entry blocker

1983 • 37 citations

PLATELET ADHESIVENESS AND AGGREGATION IN HYPERTENSIVE PATIENTS

1972 • 33 citations

Inhibition of feline collateral vessel development following experimental thrombolic occlusion.

1976 • 33 citations

Serotonin as a factor in depression of collateral blood flow following experimental arterial thrombosis.

1977 • 30 citations

Interactions of bradykinin, prostaglandin E1, 5-hydroxytryptamine, histamine and adenosine-5′-triphosphate on the dye leakage response in rat skin

1976 • 29 citations

The effects of histamine, 5‐hydroxytryptamine and bradykinin on rat mesenteric blood vessels

1969 • 28 citations

Platelets, fibroblasts, and inflammation: tissue reactions to platelets injected subcutaneously.

1980 • 27 citations

Clot-Promoting Effect of Platelet-Vessel Wall Interaction: Influence of Dietary Fats and Relation to Arterial Thrombus Formation in Rats

1979 • 26 citations

The effects of aspirin and methysergide on responses to clot-induced pulmonary embolism

1983 • 25 citations

Pharmacologic properties of antihistamines in relation to vascular reactivity

1965 • 25 citations

Platelet activation during treadmill exercise in patients with chronic peripheral arterial disease

1981 • 24 citations

Platelet Function in Acute Myocardial Infarction Patients Compared with Controls

1980 • 24 citations

INTERACTIONS BETWEEN ANGIOTENSIN, NORADRENALINE AND SEROTONIN ON THE PERIPHERAL BLOOD VESSELS IN MAN

1968 • 24 citations

Restoration of post-thrombotic peripheral collateral circulation in the cat by ketanserin, a selective 5-HT2-receptor antagonist.

1984 • 22 citations

Vascular Endothelium and Basement Membranes.

1980 • 21 citations

40. THE BIOLOGICAL AND PHARMACOLOGICAL PROPERTIES OF SOME FIBRINOGEN DEGRADATION PRODUCTS*

1971 • 20 citations

Hypoxia and spasms in the cerebral vasculature.

1982 • 18 citations

Serotonin-induced blood flow changes in the rat hindlegs after unilateral ligation of the femoral artery. Inhibition by the S2 receptor antagonist ketanserin.

1984 • 17 citations

Platelet production time, uricemia, and some hemostasis tests in pre-eclampsia

1980 • 15 citations

Platelet products and vascular PGI2 production

1983 • 13 citations

Plethysmographic Registration of Volume Changes in a Hand Vein Effects of Serotonin and of a Specific Antagonist

1980 • 12 citations

Inhibition of cold-induced vasoconstriction with ketanserin

1985 • 12 citations

Plasma beta-thromboglobulin in normal pregnancy and pregnancy-induced hypertension

1983 • 12 citations

Platelet aggregation induced by arachidonic acid and thromboxane generation in patients with hypertension or cerebrovascular disease

1981 • 11 citations

Serotonin and Vascular Function

1984 • 11 citations

The influence of weighted exercise on tissue (intramuscular) pressure in normal subjects and patients with intermittent claudication.

1973 • 10 citations

Pharmacology of Arterioles

1981 • 9 citations

Functional distinction between serotonin uptake and serotonin-induced shape change receptors in rat platelets

1982 • 7 citations

Prostaglandins and regulation of blood pressure: Clinical implications

1981 • 5 citations

Stimulation of Human Platelets under the Influence of High Shear Stresses in Tube Flow

1979 • 3 citations