Beta Agonists and the Asthma Paradox

Predominant T_H2-like Bronchoalveolar T-Lymphocyte Population in Atopic Asthma

1992 • 2,802 citations

The Use of β-Agonists and the Risk of Death and near Death from Asthma

1992 • 1,248 citations

Cellular Events in the Bronchi in Mild Asthma and after Bronchial Provocation

1989 • 1,158 citations

SUBEPITHELIAL FIBROSIS IN THE BRONCHI OF ASTHMATICS

1989 • 1,151 citations

Regular inhaled beta-agonist treatment in bronchial asthma

1990 • 1,090 citations

Comparison of a β₂-Agonist, Terbutaline, with an Inhaled Corticosteroid, Budesonide, in Newly Detected Asthma

1991 • 813 citations

Suppression by heparin of smooth muscle cell proliferation in injured arteries

1977 • 798 citations

Stereochemistry, a basis for sophisticated nonsense in pharmacokinetics and clinical pharmacology

1984 • 600 citations

Long-Term Effects of a Long-Acting β₂-Adrenoceptor Agonist, Salmeterol, on Airway Hyperresponsiveness in Patients with Mild Asthma

1992 • 463 citations

Histamine Release in vitro: Inhibition by Catecholamines and Methylxanthines

1968 • 458 citations

Changes in bronchial hyperreactivity induced by 4 weeks of treatment with antiasthmatic drugs in patients with allergic asthma: A comparison between budesonide and terbutaline

1985 • 458 citations

Effect of long-term treatment with inhaled corticosteroids and beta-agonists on the bronchial responsiveness in children with asthma

1987 • 435 citations

Toxicity of Eosinophil Cationic Proteins for Guinea Pig Tracheal EpitheliumIn Vitro

1989 • 421 citations

The assessment and treatment of asthma: A conference report

1990 • 390 citations

REBOUND INCREASE IN BRONCHIAL RESPONSIVENESS AFTER TREATMENT WITH INHALED TERBUTALINE

1988 • 343 citations

Bronchodilator treatment in moderate asthma or chronic bronchitis: continuous or on demand? A randomised controlled study.

1991 • 297 citations

Mortality from asthma: a new epidemic in New Zealand

1982 • 280 citations

Inhibition of IgE‐dependent histamine release from human dispersed lung mast cells by anti‐allergic drugs and salbutamol

1987 • 252 citations

Protection against allergen-induced asthma by salmeterol

1990 • 237 citations

Guidelines for management of asthma in adults: I--Chronic persistent asthma. Statement by the British Thoracic Society, Research Unit of the Royal College of Physicians of London, King's Fund Centre, National Asthma Campaign.

1990 • 229 citations

International trends in hospital admission rates for asthma.

1985 • 226 citations

Allergen-induced Recruitment of Bronchoalveolar Helper (OKT4) and Suppressor (OKT8) T-Cells in Asthma: Relative Increases in OKT8 Cells in Single Early Responders Compared with Those in Late-Phase Responders

1987 • 205 citations

Increased bronchial hyperresponsiveness after inhaling salbutamol during 1 year is not caused by subsensitization to salbutamol1

1990 • 199 citations

Increase in hospital admissions for childhood asthma: trends in referral, severity, and readmissions from 1970 to 1985 in a health region of the United Kingdom.

1989 • 193 citations

Antigen challenge induces pulmonary airway eosinophil accumulation and airway hyperreactivity in sensitized guinea‐pigs: the effect of anti‐asthma drugs

1990 • 189 citations

Bronchoalveolar lavage fluid mediator levels 5 minutes after allergen challenge in atopic subjects with asthma: Relationship to the development of late asthmatic responses

1991 • 184 citations

Histamine suppresses gene expression and synthesis of tumor necrosis factor alpha via histamine H2 receptors.

1991 • 165 citations

Airway response to salbutamol: effect of regular salbutamol inhalations in normal, atopic, and asthmatic subjects.

1982 • 162 citations

A new method for isolation of human lymphocyte subsets reveals differential regulation of β-adrenergic receptors by terbutaline treatment

1989 • 118 citations

Adverse effects of inhalation of excessive amounts of nebulized isoproterenol in status asthmaticus

1969 • 117 citations

The Effect of an Increase in Inhaled Allergen Dose after Rimiterol Hydrobromide on the Occurrence and Magnitude of the Late Asthmatic Response and the Associated Change in Nonspecific Bronchial Responsiveness

1989 • 113 citations

Chirality in antirheumatic drugs

1991 • 109 citations

The Inhibitory Effect of Heparin and Related Glycosaminoglycans on Neutrophil Chemotaxis

1984 • 107 citations

The multiple complexes formed by the interaction of platelet factor 4 with heparin

1980 • 104 citations

A COMPARISON OF THE ANTI‐ANAPHYLACTIC ACTIVITIES OF SALBUTAMOL AND DISODIUM CROMOGLYCATE IN THE RAT, THE RAT MAST CELL AND IN HUMAN LUNG TISSUE

1979 • 102 citations

Effect of Anticoagulants on Delayed Hypersensitivity Reactions

1967 • 97 citations

One explanation of the asthma paradox: inhibition of natural anti-inflammatory mechanism by β2-agonists

1991 • 97 citations

The 1990 Lilly Prize Lecture. A way of looking at agonism and antagonism: lessons from salbutamol, salmeterol and other beta‐ adrenoceptor agonists.

1991 • 96 citations

The protective effect of a beta 2 agonist against excessive airway narrowing in response to bronchoconstrictor stimuli in asthma and chronic obstructive lung disease.

1991 • 92 citations

Endothelial Heparan Sulfate Proteoglycan. I. Inhibitory Effects on Smooth Muscle Cell Proliferation

1990 • 89 citations

Inhibition of delayed-type hypersensitivity by heparin depleted of anticoagulant activity

1983 • 89 citations

Is current treatment increasing asthma mortality and morbidity?

1989 • 88 citations

The characteristics of inhibition of histamine release from human lung fragments by sodium cromoglycate, salbutamol and chlorpromazine

1983 • 86 citations

Asthma mortality and inhaled beta agonist therapy

1991 • 86 citations

THE USE OF ADRENAL SUBSTANCE IN THE TREATMENT OF ASTHMA.

1900 • 84 citations

New therapeutic approaches in asthma

1986 • 78 citations

Increased airway reactivity in the guinea‐pig follows exposure to intravenous isoprenaline.

1990 • 68 citations

Inhibition of allergic encephalomyelitis in rats by treatment with sulfated polysaccharides.

1988 • 67 citations

Analysis of salbutamol enantiomers in human urine by chiral high-performance liquid chromatography and preliminary studies related to the stereoselective disposition kinetics in man

1987 • 67 citations

Immunomodulating activity of heparin

1991 • 60 citations

Pressurized Aerosols in Asthma

1967 • 58 citations

Heparin inhibits the attachment and growth of Balb/c‐3T3 fibroblasts on collagen substrata

1992 • 54 citations

Early Changes in T Lymphocytes Recovered by Bronchoalveolar Lavage after Local Allergen Challenge of Asthmatic Airways

1992 • 53 citations

Clinical effects of epinephrine by inhalation

1948 • 50 citations

Analysis of the effect of mast cell granules on lymphocyte blastogenesis in the absence and presence of mitogens: identification of heparin as a granule-associated suppressor factor.

1983 • 50 citations

Evidence forIn VivoGeneration of Cytotoxic T Cells: PPD-stimulated Lymphocytes from Tuberculous Pleural Effusions Demonstrate Enhanced Cytotoxicity with Accelerated Kinetics of Induction

1992 • 47 citations

Bronchial Hyperreactivity

1982 • 47 citations

Heparin modulates human intestinal smooth muscle cell proliferation, protein synthesis, and lattice contraction

1987 • 38 citations

A Clinical and Experimental Study of Isuprel in Spontaneous and Induced Asthma

1949 • 32 citations

THE CHRONIC EFFECT OF EPINEPHRINE AND EPHEDRINE ON THE NASAL MUCOSA

1931 • 27 citations

Influence of Heparin and a Low Molecular Weight Heparin Fraction of the Leukocytes in an Experimental Venous Thrombosis Model

1987 • 13 citations

SPORADIC BACILLARY DYSENTERY IN ENGLAND

1927 • 1 citations