Laminin: molecular Organization and biological function

Laminin–a glycoprotein from basement membranes.

1979 • 2,372 citations

Ciba Foundation Symposium

1957 • 1,100 citations

Identification of an amino acid sequence in laminin mediating cell attachment, chemotaxis, and receptor binding

1987 • 677 citations

Shapes, domain organizations and flexibility of laminin and fibronectin, two multifunctional proteins of the extracellular matrix

1981 • 666 citations

Role of laminin in the attachment of PAM 212 (epithelial) cells to basement membrane collagen

1980 • 661 citations

The heparin-binding domain of laminin is responsible for its effects on neurite outgrowth and neuronal survival.

1984 • 634 citations

YIGSR, a Synthetic Laminin Pentapeptide, Inhibits Experimental Metastasis Formation

1987 • 555 citations

Support of cultured hepatocytes by a laminin-rich gel. Evidence for a functionally significant subendothelial matrix in normal rat liver.

1987 • 547 citations

The cell substrate attachment (CSAT) antigen has properties of a receptor for laminin and fibronectin.

1985 • 503 citations

Laminin-nidogen complex. Extraction with chelating agents and structural characterization

1987 • 453 citations

Isolation of a tumor cell laminin receptor

1983 • 426 citations

Laminin receptor on human breast carcinoma cells.

1983 • 419 citations

The control of the metabolism and the hormonal role of adenosine.

1978 • 416 citations

Sequence of the cDNA encoding the laminin B1 chain reveals a multidomain protein containing cysteine-rich repeats.

1987 • 381 citations

Properties of a basement membrane-related glycoprotein synthesized in culture by a mouse embryonal carcinoma-derived cell line

1979 • 364 citations

Laminin is associated with the "neurite outgrowth-promoting factors" found in conditioned media.

1985 • 346 citations

Role of laminin in the attachment and metastasis of murine tumor cells.

1982 • 334 citations

Mapping of domains in human laminin using monoclonal antibodies: localization of the neurite-promoting site.

1986 • 318 citations

Laminin is induced in astrocytes of adult brain by injury.

1984 • 315 citations

Protease Resistance and Conformation of Laminin

1982 • 313 citations

An antibody to a receptor for fibronectin and laminin perturbs cranial neural crest development in vivo

1986 • 304 citations

Increased rate of peripheral nerve regeneration using bioresorbable nerve guides and a laminin-containing gel

1985 • 303 citations

Laminin-immunoreactive glia distinguish regenerative adult CNS systems from non-regenerative ones.

1985 • 298 citations

Basement membrane glycoprotein laminin binds to heparin

1980 • 286 citations

Expression of nidogen and laminin in basement membranes during mouse embryogenesis and in teratocarcinoma cells

1985 • 272 citations

Presence of Laminin Receptors in Staphylococcus aureus

1985 • 271 citations

The role of laminin and the laminin/fibronectin receptor complex in the outgrowth of retinal ganglion cell axons

1987 • 267 citations

Laminin polymerization in vitro. Evidence for a two-step assembly with domain specificity.

1985 • 264 citations

Subunits of laminin are differentially synthesized in mouse eggs and early embryos

1983 • 263 citations

Altered levels of laminin receptor mRNA in various human carcinoma cells that have different abilities to bind laminin.

1986 • 261 citations

Retinal ganglion cells lose response to laminin with maturation

1986 • 253 citations

Do neurons in the vertebrate CNS migrate on laminin?

1985 • 245 citations

Localization of binding sites for laminin, heparan sulfate proteoglycan and fibronectin on basement membrane (type IV) collagen

1986 • 216 citations

Distribution of laminin in the developing peripheral nervous system of the chick

1986 • 209 citations

Studies on Macromolecular Components of Human Glomerular Basement Membrane and Alterations in Diabetes: Decreased Levels of Heparan Sulfate Proteoglycan and Laminin

1987 • 208 citations

Purification of a factor that promotes neurite outgrowth: isolation of laminin and associated molecules.

1985 • 207 citations

Distribution of a putative cell surface receptor for fibronectin and laminin in the avian embryo.

1986 • 203 citations

Peripheral nerve regeneration with entubulation repair: Comparison of biodegradeable nerve guides versus polyethylene tubes and the effects of a laminin-containing gel

1987 • 199 citations

Binding of laminin to type IV collagen: a morphological study.

1985 • 196 citations

Evidence for coiled-coil alpha-helical regions in the long arm of laminin.

1985 • 195 citations

Two distinct cell-binding domains in laminin can independently promote nonneuronal cell adhesion and spreading [published erratum appears in J Cell Biol 1989 Jun;108(6):following 2546]

1987 • 195 citations

Synthesis of type IV collagen and laminin in cultures of skeletal muscle cells and their assembly on the surface of myotubes

1982 • 188 citations

Laminin increases the release of type IV collagenase from malignant cells.

1986 • 188 citations

Extracellular matrix proteins (fibronectin, laminin, and type IV collagen) bind and aggregate bacteria.

1985 • 188 citations

Isolation of a subunit of laminin and its role in molecular structure and tumor cell attachment.

1982 • 182 citations

Circulating antibodies to mouse laminin in Chagas disease, American cutaneous leishmaniasis, and normal individuals recognize terminal galactosyl(alpha 1-3)-galactose epitopes.

1987 • 170 citations

Laminin and optic nerve regeneration in the goldfish

1985 • 169 citations

Cranin: a laminin-binding protein of cell membranes.

1987 • 161 citations

A laminin substrate promotes myogenesis in rat skeletal muscle cultures: Analysis of replication and development using antidesmin and anti-BrdUrd monoclonal antibodies

1987 • 160 citations

Laminin binds specifically to sulfated glycolipids.

1985 • 158 citations

Expression of laminin receptor in normal and carcinomatous human tissues as defined by a monoclonal antibody.

1985 • 150 citations

Origin of the glomerular basement membrane visualized after in vivo labeling of laminin in newborn rat kidneys.

1985 • 143 citations

Structures of the asparagine-linked sugar chains of laminin

1986 • 142 citations

Identification and interaction repertoire of large forms of the basement membrane protein nidogen.

1985 • 139 citations

A monoclonal antibody identifies a glycoprotein complex involved in cell-substratum adhesion

1985 • 136 citations

Migration of tumor cells to organ-derived chemoattractants.

1985 • 135 citations

Connective tissue proteins and phagocytic cell function. Laminin enhances complement and Fc-mediated phagocytosis by cultured human macrophages.

1985 • 127 citations

Type IV collagen and laminin‐related antigens in human serum in alcoholic liver disease

1985 • 118 citations

Role of laminin and fibronectin in selecting myogenic versus fibrogenic cells from skeletal muscle cells in vitro

1986 • 115 citations

High molecular weight extracellular proteins synthesized by endoderm cells derived from mouse teratocarcinoma cells and normal extraembryonic membranes

1980 • 108 citations

Degradation of soluble laminin and depletion of tissue-associated basement membrane laminin by Pseudomonas aeruginosa elastase and alkaline protease

1986 • 99 citations

Tumour basement membrane laminin in adenocarcinoma of rectum: An immunohistochemical study of biological and clinical significance

1986 • 93 citations

Monoclonal antibodies to the human laminin receptor recognize structurally distinct sites

1985 • 89 citations

Studies on macromolecular components of human glomerular basement membrane and alterations in diabetes. Decreased levels of heparan sulfate proteoglycan and laminin

1987 • 88 citations

Laminin increases both levels and activity of tyrosine hydroxylase in calf adrenal chromaffin cells.

1986 • 87 citations

Chemotaxis of Human Gingival Epithelial Cells to Laminin

1986 • 85 citations

Laminin promotes rabbit neutrophil motility and attachment.

1986 • 83 citations

Distribution of laminin and fibronectin along peripheral trigeminal axon pathways in the developing chick

1987 • 83 citations

Antibodies to basement membrane collagen and to laminin are present in sera from patients with poststreptococcal glomerulonephritis.

1986 • 82 citations

Immunohistochemical detection of laminin in 98 human breast carcinomas

1986 • 82 citations

Human neutrophil laminin receptors: activation-dependent receptor expression.

1987 • 81 citations

The Physiological Anatomy and Physiology of Man

1871 • 78 citations

Regenerating Fish Optic Nerves and a Regeneration-Like Response in Injured Optic Nerves of Adult Rabbits

1985 • 77 citations

Effect of age and diabetes on type IV collagen and laminin in human kidney cortex

1986 • 74 citations

Binding of laminin to oral and endocarditis strains of viridans streptococci

1987 • 73 citations

Radioimmunoassay of laminin in serum and its application to cancer patients.

1986 • 72 citations

Inhibition of laminin self-assembly and interaction with type IV collagen by antibodies to the terminal domain of the long arm.

1986 • 70 citations

Post-translational assembly and glycosylation of laminin subunits in parietal endoderm-like F9 cells

1985 • 65 citations

Laminin supports neurite outgrowth from explants of axotomized adult rat retinal neurons

1986 • 65 citations

Isolation of laminin from human placental basement membranes: Amnion, chorion and chorionic microvessels

1983 • 63 citations

In vitro synthesis of laminin and entactin polypeptides.

1983 • 60 citations

Response of purified chick motoneurons to myotube conditioned medium: Laminin is essential for the substratum-binding, neurite outgrowth-promoting activity

1985 • 59 citations

Radioimmunoassay of laminin in serum and its application to cancer patients.

1986 • 59 citations

Differential proteolytic susceptibility of laminin alpha and beta subunits

1982 • 59 citations

Serum Procollagen Type III N‐Terminal Peptides and Laminin P1 Peptide in Alcoholic Liver Disease

1987 • 58 citations

Laminin production by human endometrial stromal cells relates to the cyclic and pathologic state of the endometrium.

1986 • 58 citations

Regenerating dorsal roots and the nerve entry zone: An immunofluorescence study with neurofilament and laminin antisera

1984 • 58 citations

Serum concentrations of laminin and aminoterminal propeptide of type III procollagen in relation to the portal venous pressure of fibrotic liver diseases

1986 • 58 citations

Antibodies to laminin in preeclampsia

1986 • 57 citations

The extracellular matrix proteins laminin and fibronectin modify the AMPase activity of 5'‐nucleotidase from chicken gizzard smooth muscle

1986 • 57 citations

Post-embedding colloidal gold immunolocalization of laminin to the lamina rara interna, lamina densa, and lamina rara externa of renal glomerular basement membranes.

1986 • 56 citations

The C1q subunit of the first component of complement binds to laminin: a mechanism for the deposition and retention of immune complexes in basement membrane.

1985 • 55 citations

C3d fragment of complement interacts with laminin and binds to basement membranes of glomerulus and trophoblast.

1986 • 55 citations

Macrophages express a plasma membrane receptor for basement membrane laminin.

1986 • 54 citations

Cellular immunity to collagen and laminin in scleroderma

1985 • 52 citations

Expression of a laminin-like substance on the surface of murine natural killer (NK) lymphocytes and its role in NK recognition of tumor target cells.

1985 • 51 citations

Clustering of cell surface laminin enhances its association with the cytoskeleton

1986 • 49 citations

Expression of Fibronectin, Laminin, and Factor VIII-Related Antigen During Development of the Human Cutaneous Microvasculature

1985 • 48 citations

Developmental regulation of laminin accumulation in the extracellular matrix of a mouse muscle cell line

1985 • 47 citations

Laminin and fibronectin in adenoid cystic carcinoma.

1986 • 46 citations

In vivo guidance of regenerating nerve by laminin-coated filaments

1987 • 45 citations

Laminin distribution in human decidua and immature placenta

1985 • 45 citations

Fibronectin, Laminin, Type I, III and IV Collagens in Duchenne's Muscular Dystrophy, Congenital Muscular Dystrophies and Congenital Myopathies: An Immunocytochemical Study

1985 • 41 citations

Binding domain for laminin on type IV collagen

1985 • 39 citations

Distribution of fibronectin and laminin in normal and pathological lymphoid tissue.

1985 • 37 citations

Structural analysis of three subunits of laminin from teratocarcinoma-derived parietal endoderm cells

1983 • 36 citations

Laminin M is Found in Placental Basement Membranes, But Not in Basement Membranes of Neoplastic Origin

1986 • 36 citations

Nephritogenic potential of sheep antibodies against glomerular basement membrane laminin in the rat.

1986 • 32 citations

Laminin-immunoreactive sites are induced by growth-associated triggering factors in injured rabbit optic nerve

1987 • 30 citations

Distinct antigenic characteristics of murine parietal yolk sac laminin

1987 • 30 citations

Isolation, Purification and Characterization of Intact and Pepsin-Derived Fragments of Laminin from Human Placenta

1985 • 30 citations

Effect of adhesion factors fibronectin, laminin, and type IV collagen on spreading and growth of transformed and control rat liver epithelial cells.

1987 • 29 citations

Laminin inhibits the recognition of tumor target cells by murine natural killer (NK) and natural cytotoxic (NC) lymphocytes.

1985 • 29 citations

Serum concentration of laminin, and course of the disease in patients with various malignancies.

1987 • 29 citations

Extracellular Hyaline Bodies Are Basement Membrane Accumulations

1987 • 28 citations

Extensive laminin and basement membrane accumulation occurs at the onset of bleomycin-induced rodent pulmonary fibrosis.

1986 • 26 citations

Response of astrocytes in the visual system to Wallerian degeneration: An immunohistochemical analysis of laminin and glial fibrillary acidic protein (GFAP)

1986 • 23 citations

Localization of Basement Membrane Components in Mucous Membrane Pemphigoid

1985 • 23 citations

Follicular thyroid tumours: a study of laminin and type IV collagen in basement membrane and endothelium.

1985 • 23 citations

The interaction of 5′-nucleotidase purified from chicken gizzard and actin, and the reversible loss of the inhibitory capacity of actin on deoxyribonuclease I

1985 • 21 citations

Laminin immunostaining in hyperplastic, dysplastic, and neoplastic lesions of the endometrium and uterine cervix.

1987 • 21 citations

Butyrate induced reduction of tumor cell laminin receptors.

1986 • 16 citations

Distribution of fibronectin and laminin in oral leukoplakia and carcinoma

1985 • 15 citations

A potential role for the extracellular matrix glycoprotein laminin in macrophage‐tumor‐cell interactions

1985 • 15 citations

Laminin selectively enhances monocyte-macrophage-mediated tumoricidal activity.

1985 • 14 citations

Accumulation of laminin and type IV collagen in the kidney in congenital nephrosis

1985 • 14 citations

Gangliosides indirectly inhibit the binding of laminin to sulfatides

1986 • 11 citations

Abnormal Laminin Secretion from Parietal Endoderm-Like F9 Cells in the Presence of Monensin1

1985 • 11 citations

Mesoblastic nephroma contains fibronectin but lacks laminin.

1985 • 11 citations

Amniotic fluid laminin and type IV collagen in normal and pathological pregnancies

1985 • 9 citations