Copper in biological systems. A report from the 6th Manziana conference, September 23–27, 1990

X-ray absorption edge determination of the oxidation state and coordination number of copper. Application to the type 3 site in Rhus vernicifera laccase and its reaction with oxygen

1987 • 976 citations

Novel thioether bond revealed by a 1.7 Å crystal structure of galactose oxidase

1991 • 734 citations

A New Redox Cofactor in Eukaryotic Enzymes: 6-Hydroxydopa at the Active Site of Bovine Serum Amine Oxidase

1990 • 650 citations

The blue oxidases, ascorbate oxidase, laccase and ceruloplasmin Modelling and structural relationships

1990 • 436 citations

X-ray crystal structure of the blue oxidase ascorbate oxidase from Zucchini

1989 • 416 citations

.mu.-.eta.2:.eta.2-Peroxo binuclear copper complex, [Cu(HB(3,5-(Me2CH)2pz)3)]2(O2)

1989 • 381 citations

Copper activates metallothionein gene transcription by altering the conformation of a specific DNA binding protein

1988 • 365 citations

The 2.3 Angstrom X-Ray Structure of Nitrite Reductase from Achromobacter cycloclastes

1991 • 352 citations

Specific detection of quinoproteins by redox-cycling staining.

1991 • 336 citations

ACE1 regulates expression of the Saccharomyces cerevisiae metallothionein gene.

1988 • 321 citations

Control of Escherichia coli superoxide dismutase (sodA and sodB) genes by the ferric uptake regulation (fur) locus

1990 • 268 citations

Acta Crystallographica

1947 • 260 citations

Electronic structure of plastocyanin: excited state spectral features

1988 • 252 citations

Chemical nucleases

1990 • 241 citations

Bovine serum amine oxidase: a mammalian enzyme having covalently bound PQQ as prosthetic group

1984 • 230 citations

A Cu(I)-semiquinone state in substrate-reduced amine oxidases

1991 • 228 citations

Copper-dioxygen chemistry: a bioinorganic challenge

1989 • 210 citations

The active site of galactose oxidase.

1988 • 209 citations

A predictive theoretical model for electron tunneling pathways in proteins

1990 • 209 citations

The nuclear modulation effect in electron spin echoes for complexes of Cu2+ and imidazole with 14N and 15N

1978 • 187 citations

Reaction aspects of a .mu.-peroxo binuclear copper(II) complex

1990 • 186 citations

A tyrosine-derived free radical in apogalactose oxidase.

1990 • 184 citations

Involvement of the hydrophobic patch of azurin in the electron‐transfer reactions with cytochrome c₅₅₁ and nitrite reductase

1990 • 183 citations

Reconstitution of Cu,Zn-superoxide dismutase by the Cu(I).glutathione complex.

1990 • 155 citations

An electronic structural comparison of copper-peroxide complexes of relevance to hemocyanin and tyrosinase active sites

1991 • 151 citations

The copper, zinc-superoxide dismutase gene of Saccharomyces cerevisiae: cloning, sequencing, and biological activity.

1988 • 147 citations

Nitrous oxide reductase from Pseudomonas stutzeri

1989 • 143 citations

Spectroscopic and chemical studies of the laccase trinuclear copper active site: geometric and electronic structure

1990 • 141 citations

X-ray crystal structure of the two site-specific mutants His35Gln and His35Leu of azurin from Pseudomonas aeruginosa

1991 • 139 citations

CHEMICAL NUCLEASES: NEW REAGENTS IN MOLECULAR BIOLOGY

1990 • 135 citations

Multifrequency EPR evidence for a bimetallic center at the Cu_A site in cytochrome c oxidase

1990 • 132 citations

Low-temperature magnetic circular dichroism studies of native laccase: confirmation of a trinuclear copper active site

1986 • 132 citations

Properties of a copper-containing cytochrome ba3: a second terminal oxidase from the extreme thermophile Thermus thermophilus.

1988 • 126 citations

Point charge distributions and electrostatic steering in enzyme/substrate encounter: Brownian dynamics of modified copper/zinc superoxide dismutases

1990 • 123 citations

Covalent attachment of proteins to polysaccharide carriers by means of benzoquinone

1975 • 122 citations

Electron spin-echo studies of the copper binding site in phenylalanine hydroxylase from Chromobacterium violaceum

1988 • 119 citations

Low-temperature magnetic circular dichroism studies of native laccase: spectroscopic evidence for exogenous ligand bridging at a trinuclear copper active site.

1985 • 117 citations

Resonance Raman evidence for tyrosine involvement in the radical site of galactose oxidase

1989 • 114 citations

Structure of the Gene for the Arylphorin-type Storage Protein SP 2 of Bombyx mori

1989 • 111 citations

Nuclear quadrupole interactions in copper(II)-diethylenetriamine-substituted imidazole complexes and in copper(II) proteins

1990 • 111 citations

cDNA and gene sequence of Manduca sexta arylphorin, an aromatic amino acid-rich larval serum protein

1989 • 110 citations

Chemical Conversion of a DNA-Binding Protein into a Site-Specific Nuclease

1987 • 110 citations

Site-directed mutagenesis reveals that the hydrophobic patch of azurin mediates electron transfer

1990 • 108 citations

Selective removal of type 2 copper from Rhus vernicifera laccase

1976 • 100 citations

pH-dependent redox activity and fluxionality of the copper site in amicyanin from Thiobacillus yersutus as studied by 300- and 600- MHz 1H NMR.

1990 • 98 citations

The reaction of Pseudomonas nitrite reductase and nitrite. A stopped-flow and EPR study.

1990 • 97 citations

Evidence for co-regulation of Cu,Zn superoxide dismutase and metallothionein gene expression in yeast through transcriptional control by copper via the ACE 1 factor

1991 • 94 citations

Synthesis and reactivity of a family of copper monooxygenase model systems

1988 • 94 citations

Kinetic studies of Rhus vernicifera laccase

1976 • 90 citations

Peptides in the nervous system

1986 • 88 citations

Covalently bound pyrroloquinoline quinone is the organic prosthetic group in human placental lysyl oxidase

1986 • 88 citations

Cooperative activation of a eukaryotic transcription factor: interaction between Cu(I) and yeast ACE1 protein.

1989 • 86 citations

NMR study of structure and electron transfer mechanism of Pseudomonas aeruginosa azurin.

1988 • 83 citations

Human copper-zinc superoxide dismutase complements superoxide dismutase-deficient Escherichia coli mutants.

1987 • 81 citations

Structure and function of copper proteins Report, on the fourth La Cura Conference held at Villa Giulia, Manziana, Rome, Italy, 4-8 September 1979

1980 • 80 citations

Sequence similarity between dopamine β‐hydroxylase and peptide α‐amidating enzyme: Evidence for a conserved catalytic domain

1989 • 75 citations

Oxidation-state assignments for galactose oxidase complexes from x-ray absorption spectroscopy. Evidence for copper(II) in the active enzyme

1990 • 75 citations

Chemical and spectroscopic properties of the binuclear copper active site in Rhus laccase: direct confirmation of a reduced binuclear type 3 copper site in type 2 depleted laccase and intramolecular coupling of the type 3 to the type 1 and type 2 copper sites

1981 • 75 citations

Hydrazone formation of 2,4‐dinitrophenylhydrazine with pyrroloquinoline quinone in porcine kidney diamine oxidase

1986 • 74 citations

Electron transfer between cytochrome a and copper A in cytochrome c oxidase: a perturbed equilibrium study

1989 • 74 citations

Copper transport from ceruloplasmin: characterization of the cellular uptake mechanism

1990 • 74 citations

Kinetic studies of Rhus vernicifera laccase

1976 • 73 citations

Molecular cloning and nucleotide sequence of full-length cDNA for ascorbate oxidase from cultured pumpkin cells

1990 • 72 citations

Long-range intramolecular electron transfer in azurins.

1989 • 69 citations

Amino acid sequence of nitrite reductase: a copper protein from Achromobacter cycloclastes

1991 • 69 citations

Reductive trapping of substrate to bovine plasma amine oxidase.

1987 • 67 citations

Different origins of metal binding sites in binuclear copper proteins, tyrosinase and hemocyanin

1986 • 65 citations

Electron transfer process in cytochrome oxidase after pulse radiolysis

1989 • 63 citations

Phenylalanine hydroxylase from Chromobacterium violaceum is a copper-containing monooxygenase. Kinetics of the reductive activation of the enzyme

1986 • 62 citations

Heterocyclic 1,2,4,6-thia- and 1,2,4,6-selenatriazinyl radicals: spin distributions and modes of association

1990 • 60 citations

Electron spin-echo studies of the copper(II) binding sites in dopamine .beta.-hydroxylase

1988 • 58 citations

A mixed-metal derivative of laccase containing mercury(II) in the type 1 binding site

1984 • 56 citations

Cloning and sequencing of the structural gene for the small subunit of methylamine dehydrogenase from Methylobacteriumextorquens AM1: Evidence for two tryptophan residues involved in the active center

1990 • 56 citations

Dioxygen-copper reactivity. Comparisons of the reactions of electrophiles and other reagents with three classes of peroxo-dicopper(II), {Cu2-O2}n+, species

1989 • 55 citations

The copper sites of dopamine .beta.-hydroxylase: an x-ray absorption spectroscopic study

1988 • 55 citations

Electronic structure of peroxide bridged copper dimers of relevance to oxyhemocyanin

1990 • 52 citations

Chicken ceruloplasmin. Evidence in support of a trinuclear cluster involving type 2 and 3 copper centers.

1988 • 51 citations

Copper and the ACE1 regulatory protein reversibly induce yeast metallothionein gene transcription in a mouse extract.

1989 • 50 citations

Cytochrome oxidase genes from Thermus thermophilus. Nucleotide sequence and analysis of the deduced primary structure of subunit IIc of cytochrome caa3.

1991 • 49 citations

Detailed spectroscopic analysis of half-met hemocyanins: mixed-valent contributions to electronic properties and structure

1989 • 48 citations

Measurement of 14N superhyperfine frequencies in stellacyanin by an electron spin echo method.

1979 • 48 citations

Proton NMR studies of the cobalt(II)-metallothionein system

1989 • 45 citations

Methylamine oxidase from Arthrobacter P1. A bacterial copper-quinoprotein amine oxidase

1986 • 45 citations

Activation and induction by copper of Cu/Zn superoxide dismutase in Saccharomyces cerevisiae

1991 • 44 citations

Cobalt tyrosinase: replacement of the binuclear copper of Neurospora tyrosinase by cobalt

1981 • 44 citations

Characterization of a carbon monoxide complex of reduced dopamine beta-hydroxylase. Evidence for inequivalence of the Cu(I) centers.

1990 • 43 citations

Electron transfer to the binuclear center in cytochrome oxidase: catalytic significance and evidence for an additional intermediate.

1990 • 41 citations

Chemical and spectroscopic studies of the coupled binuclear copper site in type 2 depleted Rhus laccase. Comparison to the hemocyanins and tyrosinase

1987 • 39 citations

Status of the cofactor identity in copper oxidative enzymes

1991 • 39 citations

Studies on the active site of pig plasma amine oxidase

1989 • 38 citations

Roles of the two copper ions in bovine serum amine oxidase

1986 • 38 citations

Characterization of the Bacillus stearothermophilus manganese superoxide dismutase gene and its ability to complement copper/zinc superoxide dismutase deficiency in Saccharomyces cerevisiae

1990 • 38 citations

Cloning and characterization of two alternatively spliced rat α-amidating enzyme cDNAs from rat medullary thyroid carcinoma

1990 • 38 citations

The reaction of nitric oxide with ceruloplasmin

1973 • 37 citations

Peptide substrate specificity of the α‐amidating enzyme isolated from rat medullary thyroid CA‐77 cells

1990 • 37 citations

Pulsed ENDOR study of the native and high pH perturbed forms of the blue copper site in stellacyanin

1991 • 36 citations

Yeast copper-thionein can reconstitute the Japanese-lacquer-tree (Rhus vernicifera) laccase from the Type 2-copper-depleted enzyme via a direct copper(I)-transfer mechanism

1983 • 36 citations

Reactions of bovine serum amine oxidase with NN-diethyldithiocarbamate. Selective removal of one copper ion

1987 • 36 citations

Mechanistic studies on phenylalanine hydroxylase from Chromobacterium violaceum. Evidence for the formation of an enzyme-oxygen complex

1989 • 34 citations

Isolation and characterization of cytochrome c₅₅₀ from the methylamine‐oxidizing electron‐transport chain of Thiobacillus versutus

1990 • 33 citations

Spectral Studies of Bovine Dopamine β-Hydroxylase

1989 • 33 citations

EXAFS analysis of the pH dependence of the blue-copper site in amicyanin from Thiobacillus versutus

1991 • 33 citations

The role of copper in the stability of ascorbate oxidase towards denaturing agents

1990 • 33 citations

Heterogeneity of the Type 3 copper in Japanese-lacquer-tree (Rhus vernicifera) laccase

1982 • 32 citations

X-ray Absorption Spectroscopic Study of the Active Copper Sites in Dopamine β-Hydroxylase

1989 • 32 citations

Structural characterization of mercury-substituted copper proteins. Results from x-ray absorption spectroscopy

1989 • 32 citations

The copper site in nitrous oxide reductase

1990 • 31 citations

Adduct formation between the cupric site of phenylalanine hydroxylase from Chromobacterium violaceum and 6,7-dimethyltetrahydropterin

1987 • 31 citations

Changes in CuZn-superoxide dismutase during induced differentiation of murine erythroleukemia cells.

1988 • 31 citations

Direct electrochemistry of the blue copper proteins pseudoazurin, plantacyanin, and stellacyanin

1990 • 30 citations

Immunohistochemical localization of ascorbate oxidase in cucurbita pepo medullosa

1989 • 29 citations

Benzylhydrazine as a pseudo-substrate of bovine serum amine oxidase

1989 • 28 citations

Cloned yeast and mammalian transcription factor TFIID gene products support basal but not activated metallothionein gene transcription.

1990 • 27 citations

Coordination chemistry of copper-containing amine oxidases: nuclear magnetic relaxation dispersion studies of copper binding, solvent-water exchange, substrate and inhibitor binding, and protein aggregation

1991 • 26 citations

The reaction of CN− with the binuclear copper site of Neurospora tyrosinase: its relevance for a comparison between tyrosinase and hemocyanin active sites

1990 • 25 citations

Temperature and anation studies of the type 2 site in Rhus vernicifera laccase

1990 • 25 citations

Dependence on freezing of the geometry and redox potential of type 1 and type 2 copper sites of Japanese-lacquer-tree (Rhus vernicifera) laccase

1981 • 25 citations

Inhibition of copper-dependent amine oxidases by some hydrazides of pyrrol-1-ylbenzoic and pyrrol-1-ylphenylacetic acids

1988 • 24 citations

Characterization of the gene encoding the hemocyanin subunit e from the tarantula Eurypelma californicum.

1990 • 24 citations

Primary amino acid sequence of bovine dopamine beta-hydroxylase.

1990 • 24 citations

Pulsed electron-nuclear-electron triple resonance spectroscopy

1990 • 24 citations

The nature of Cux in cytochrome c oxidase

1991 • 24 citations

Proton NMR spectra of the Co4S11 cluster in metallothioneins: a theoretical model

1989 • 23 citations

On the spectral features associated with peroxide reactivity of the coupled binuclear copper active site in type 2 depleted and native Rhus laccase

1984 • 23 citations

Anion binding to Rhus vernicifera laccase

1974 • 23 citations

Purification and characterization of functional recombinant alpha-amidating enzyme secreted from mammalian cells.

1990 • 23 citations

The multidomain structure of ceruloplasmin from calorimetric and limited proteolysis studies.

1990 • 22 citations

Antiinflammatory reactivity of copper(I)-thionein

1990 • 22 citations

Single-crystal electron spin-echo envelope modulation study of copper(II)-doped zinc bis(1,2-dimethylimidazole) dichloride

1990 • 22 citations

Domains in bovine serum amine oxidase

1988 • 20 citations

Removal of type 2 Cu from ascorbate oxidase and laccase by reaction with n,n-diethyldithiocarbamate

1987 • 20 citations

Copper-thionein in melanoma

1989 • 19 citations

Resonance Raman spectroscopy of methylamine dehydrogenase from bacterium W3A1

1991 • 19 citations

Reductive trapping of substrate to methylamine oxidase from Arthrobacter P1

1990 • 19 citations

Active site labeling of dopamine beta-hydroxylase by two mechanism-based inhibitors: 6-hydroxybenzofuran and phenylhydrazine.

1990 • 18 citations

Metals of Bovine Heart Cytochrome c Oxidasea

1988 • 18 citations

Unusual stability properties of a reptilian ceruloplasmin

1990 • 18 citations

Failure to verify the presence of pyrroloquinoline quinone (PQQ) in bovine plasma amine oxidase by gas chromatography/mass spectrometry

1990 • 18 citations

A study of the biochemical pharmacology of 3,5-ethoxy-4-aminomethylpyridine (B24), a novel amine oxidase inhibitor with selectivity for tissue bound semicarbazide-sensitive amine oxidase enzymes

1990 • 18 citations

Crystallization of nitrite reductase from Achromobacter cycloclastes

1988 • 16 citations

Conservation of local electric fields in the evolution of Cu,Zn superoxide dismutase

1989 • 15 citations

Cobalt(II)-hemocyanin: a model for the cuprous deoxy protein giving evidence for a bridging ligand in the active site

1986 • 15 citations

Cu(I)-thionein release from copper-loaded yeast cells

1989 • 15 citations

A method for the isolation and identification of pyridoxal phosphate in proteins

1990 • 15 citations

Some Properties of Nitrosomonas europaea Cytochrome c Oxidase (aa3-Type) Which Lacks CuA

1989 • 15 citations

Ready to use p-Benzoquinone activated supports for biochemical coupling, with special applications for laccase immobilization

1989 • 14 citations

The role of copper in bovine serum amine oxidase

1990 • 14 citations

Kinetic features of ascorbic acid oxidase after partial deglycation

1989 • 14 citations

Nature of the organic cofactor of pig plasma benzylamine oxidase

1990 • 13 citations

Isolation and Partial Sequence of the A‐Protein Gene of Thermus thermophilus Cytochrome c₁aa₃a

1988 • 13 citations

Efficiency of nitrilotriacetate in the removal of type 2 copper from laccase and ascorbate oxidase

1990 • 13 citations

Preparation, spectroscopic characterization and anion binding studies of a mononuclear Co(II) derivative of carcinus maenas hemocyanin

1986 • 12 citations

Copper-thionein in leucocytes

1989 • 12 citations

Release of copper from yeast copper-thionein after S-alkylation of copper-thiolate clusters

1988 • 12 citations

Specific immobilization of laccase onp-benzoquinone-activated supports

1990 • 10 citations

A room temperature electron paramagnetic resonance study of native and fluoride-reacted vietnamese and japanese lacquer-tree laccases: differences from liquid-nitrogen spectra

1985 • 10 citations

Model mono-oxygenase reaction by binuclear copper(I) complexes involves an oxygen protonated intermediate

1988 • 9 citations

Copper transfer through the intestinal wall Serosal release of metallothionein

1990 • 9 citations

Cobalt(II)-substituted Limulus polyphemus hemocyanin: cobalt equilibria, ligand binding, and oxygenation chemistry

1990 • 7 citations

The reaction of nitrite with the haemocyanin of the Roman snail (Helix pomatia)

1990 • 5 citations

Copper amine oxidases: Current state of knowledge

1990 • 3 citations

The kinetics of electron entry in cytochromec oxidase

1990 • 2 citations