Does transferrin have a special role in the nervous system?

Structure and function of the blood–brain barrier

2009 • 4,310 citations

Comparative aspects of the brain growth spurt

1979 • 2,491 citations

FERRITIN: STRUCTURE, GENE REGULATION, AND CELLULAR FUNCTION IN ANIMALS, PLANTS, AND MICROORGANISMS

1987 • 1,305 citations

Transferrin receptor on endothelium of brain capillaries

1984 • 1,008 citations

Serum-free cell culture: a unifying approach

1980 • 964 citations

Iron-Responsive Elements: Regulatory RNA Sequences That Control mRNA Levels and Translation

1988 • 707 citations

Iron transport and storage

1987 • 688 citations

Peripheral Neuropathy.

1976 • 685 citations

Human cell surface glycoprotein related to cell proliferation is the receptor for transferrin.

1981 • 685 citations

A stem-loop in the 3′ untranslated region mediates iron-dependent regulation of transferrin receptor mRNA stability in the cytoplasm

1988 • 565 citations

Human lactotransferrin: amino acid sequence and structural comparisons with other transferrins

1984 • 531 citations

Receptor‐mediated transcytosis of transferrin across the blood‐brain barrier

1987 • 523 citations

The regional distribution and cellular localization of iron in the rat brain

1984 • 487 citations

Transferrin receptor induction in mitogen-stimulated human T lymphocytes is required for DNA synthesis and cell division and is regulated by interleukin 2.

1983 • 448 citations

The localization of populations of lymphocytes defined by monoclonal antibodies in rat lymphoid tissues.

1981 • 389 citations

Modulation of cell surface iron transferrin receptors by cellular density and state of activation

1979 • 366 citations

Sertoli cells synthesize and secrete transferrin-like protein.

1980 • 360 citations

Human blood-brain barrier transferrin receptor

1987 • 347 citations

The human transferrin receptor gene: genomic organization, and the complete primary structure of the receptor deduced from a cDNA sequence

1984 • 337 citations

Cooperativity between Sertoli cells and testicular peritubular cells in the production and deposition of extracellular matrix components.

1985 • 331 citations

Human transferrin: cDNA characterization and chromosomal localization.

1984 • 320 citations

Biosynthesis of the human transferrin receptor in cultured cells.

1981 • 316 citations

Transferrin, biochemistry, physiology and clinical significance

1981 • 310 citations

Central nervous system demyelination and remyelination in the mouse: an ultrastructural study of cuprizone toxicity.

1978 • 293 citations

Human melanoma-associated antigen p97 is structurally and functionally related to transferrin

1982 • 288 citations

Secretion of Testicular Transferrin by Cultured Sertoli Cells is Regulated by Hormones and Retinoids

1982 • 253 citations

Brain neurons develop in a serum and glial free environment: effects of transferrin, insulin- insulin-like growth factor-I and thyroid hormone on neuronal survival, growth and differentiation

1987 • 249 citations

Development of the brain stem in the rat. V. Thymidine‐radiographic study of the time of origin of neurons in the midbrain tegmentum

1981 • 232 citations

Primary structure of the human melanoma-associated antigen p97 (melanotransferrin) deduced from the mRNA sequence.

1986 • 232 citations

Rat transferrin gene expression: tissue-specific regulation by iron deficiency.

1986 • 222 citations

Noncoding 3′ sequences of the transferrin receptor gene are required for mRNA regulation by iron.

1987 • 220 citations

Isolation and characterization of the transferrin receptor from human placenta.

1979 • 215 citations

Transferrin gene expression visualized in oligodendrocytes of the rat brain by using in situ hybridization and immunohistochemistry.

1985 • 214 citations

Transferrin receptors in rat brain: neuropeptide-like pattern and relationship to iron distribution.

1985 • 209 citations

Coated vesicles from human placenta carry ferritin, transferrin, and immunoglobulin G.

1982 • 208 citations

Embryonic divergence of oligodendrocyte and astrocyte lineages in developing rat cerebrum

1988 • 204 citations

The transferrin receptor

1982 • 202 citations

Human cell-surface glycoprotein with unusual properties

1980 • 201 citations

Molecular cloning and nucleotide sequence of a transforming gene detected by transfection of chicken B-cell lymphoma DNA

1983 • 194 citations

Identification and molecular cloning of the human Blym transforming gene activated in Burkitt's lymphomas

1983 • 192 citations

High prealbumin and transferrin mRNA levels in the choroid plexus of rat brain

1985 • 190 citations

Identification of transferrin receptors on the surface of human cultured cells.

1979 • 185 citations

Transferrin receptor in human placental brush border membranes. Studies on the binding of transferrin to placental membrane vesicles and the identification of a placental brush border glycoprotein with high affinity for transferrin.

1979 • 174 citations

Spatial and temporal patterns of oligodendrocyte differentiation in rat cerebrum and cerebellum

1988 • 174 citations

Development of the brain stem in the rat. I. Thymidine‐radiographic study of the time of origin of neurons of the lower medulla

1980 • 171 citations

Rat choroid plexus specializes in the synthesis and the secretion of transthyretin (prealbumin). Regulation of transthyretin synthesis in choroid plexus is independent from that in liver.

1986 • 167 citations

Translation of ferritin light and heavy subunit mRNAs is regulated by intracellular chelatable iron levels in rat hepatoma cells.

1987 • 165 citations

Both subunits of rat liver ferritin are regulated at a translational level by iron induction

1986 • 164 citations

Regeneration of Oligodendroglia During Recovery from Demyelinating Disease

1977 • 159 citations

The action of estrogen and progesterone on the expression of the transferrin gene. A comparison of the response in chick liver and oviduct.

1978 • 154 citations

The distribution of transferrin immunoreactivity in the rat central nervous system

1986 • 149 citations

Sequence analysis of a Kpnl family member near the 3′ end of human β-globin gene

1985 • 146 citations

Distribution of transferrin synthesis in brain and other tissues in the rat.

1987 • 144 citations

Topographical and cytological localization of iron in rat and monkey brains

1981 • 142 citations

Organization of the human transferrin gene: direct evidence that it originated by gene duplication.

1985 • 136 citations

Effect of iron chelators on the transferrin receptor in K562 cells.

1984 • 134 citations

Adaptive responses of rat tissue isoferritins to iron administration. Changes in subunit synthesis, isoferritin abundance, and capacity for iron storage.

1981 • 131 citations

Transcriptional regulation by iron of the gene for the transferrin receptor.

1986 • 131 citations

Expression of the transferrin gene during development of non-hepatic tissues: High level of transferrin mRNA in fetal muscle and adult brain

1984 • 129 citations

"Retroposon" insertion into the cellular oncogene c-myc in canine transmissible venereal tumor.

1985 • 128 citations

Nonidentical distribution of transferrin and ferric iron in human brain

1988 • 127 citations

Coexistence of α-fetoprotein, albumin and transferrin immunoreactivity in neurones of the developing mouse brain

1980 • 124 citations

Development of transferrin‐positive oligodendrocytes in the rat central nervous system

1987 • 119 citations

An autoradiographic study of cellular proliferation in remyelination of the central nervous system.

1979 • 116 citations

Effects of alterations in cellular iron on biosynthesis of the transferrin receptor in K562 cells.

1985 • 113 citations

�Noir de Diaminobenzidine�: Une nouvelle m�thode histochimique de r�v�lation du fer exog�ne

1980 • 112 citations

Changes in insulin and transferrin requirements of pure brain neuronal cultures during embryonic development.

1986 • 109 citations

Conservation of ferritin heavy subunit gene structure: implications for the regulation of ferritin gene expression.

1987 • 109 citations

Regulation of vertebrate limb regeneration

1985 • 108 citations

Transferrin synthesis by inducer T lymphocytes.

1986 • 107 citations

Identification of transferrin as a lymphocyte growth promoter in human serum

1972 • 105 citations

A myotrophic protein from chick embryo extract: Its purification, identity to transferrin, and indispensability for avian myogenesis

1982 • 103 citations

PRENATAL ONTOGENESIS OF ASTROCYTES

1986 • 99 citations

Transferrin and Its Receptor: Their Roles in Cell Function

1985 • 98 citations

Characterization and evolution of the expressed rat ferritin light subunit gene and its pseudogene family. Conservation of sequences within noncoding regions of ferritin genes.

1987 • 95 citations

Development of the brain stem in the rat. IV. Thymidine‐radiographic study of the time of orgin of neurons in the pontine region

1980 • 94 citations

Role of transferrin, Fe, and transferrin receptors in myeloid leukemia cell growth. Studies with an antitransferrin receptor monoclonal antibody.

1985 • 89 citations

Structure and expression of the chicken ferritin H-subunit gene.

1987 • 85 citations

Synthesis, Processing, and Secretion of Plasma Proteins by the Liver and Other Organs and Their Regulation

1987 • 83 citations

Purification and characterization of testicular transferrin secreted by rat Sertoli cells

1984 • 83 citations

The Development of the Blood-Brain Barrier

1968 • 82 citations

Transferrin Binding to Peripheral Blood Lymphocytes Activated by Phytohemagglutinin Involves a Specific Receptor

1980 • 82 citations

�ber die Entwicklung von Ependym und Plexus chorioideus der Ratte

1967 • 81 citations

The demonstration of recurrent demyelination and remyelination of axons in the central nervous system

1981 • 81 citations

Synthesis of plasma proteins in fetal, adult, and neoplastic human brain tissue

1986 • 80 citations

Transferrin can replace serum forin vitro growth of mitogen-stimulated T lymphocytes

1979 • 80 citations

Transferrin mRNA level in the mouse mammary gland is regulated by pregnancy and extracellular matrix.

1987 • 79 citations

Assignment of the gene for human melanoma-associated antigen p97 to chromosome 3

1983 • 79 citations

A sciatic nerve protein has a trophic effect on development and maintenance of skeletal muscle cells in culture.

1979 • 78 citations

Cell proliferation and expression of the transferrin receptor gene: promoter sequence homologies and protein interactions.

1986 • 76 citations

Differential turnover of rat liver isoferritins.

1980 • 76 citations

Interactions of DNA-binding proteins with the 5′ region of the human transferrin gene.

1988 • 76 citations

Biological effects of transferrin on human lymphocytes in vitro

1972 • 74 citations

Human placental coated vesicles contain receptor-bound transferrin

1981 • 71 citations

The perineuronal satellite oligodendrocyte

1979 • 68 citations

Transferrin gene expression in choroid plexus of the adult rat brain

1987 • 67 citations

Transferrin Receptor in Human Placental Brush Border Membranes

1979 • 67 citations

Glial conditioned medium enables jimpy oligodendrocytes to express properties of normal oligodendrocytes: Production of myelin antigens and membranes

1988 • 65 citations

Interaction of transferrin with iron-loaded rat peritoneal macrophages

1986 • 65 citations

An ultrastructural study of experimental demyelination and remyelination. V. Central and peripheral nervous system lesions caused by diphtheria toxin.

1971 • 59 citations

Immunocytochemical distribution of transferrin and its receptor in the developing chicken nervous system

1986 • 57 citations

Immunohistochemical identification of some plasma proteins in human embryonic and fetal forebrain with particular reference to the development of the neocortex

1984 • 57 citations

The distribution of plasma proteins in the neocortex and early allocortex of the developing sheep brain

1985 • 56 citations

Molecular cloning and sequence analysis of cDNA for human transferrin

1984 • 54 citations

The human transferrin gene: 5′ region contains conserved sequences which match the control elements regulated by heavy metals, glucocorticoids and acute phase reaction

1986 • 54 citations

The identification of neurotrophic factor as a transferrin

1983 • 53 citations

Plasma proteins in fetal sheep brain: blood‐brain barrier and intracerebral distribution.

1981 • 52 citations

Localization of a gene controlling the expression of the human transferrin receptor to the region q12→qter of chromosome 3

1983 • 51 citations

Class specificity of transferrin as a muscle trophic factor

1986 • 51 citations

Iron uptake and regulation of ferritin synthesis by hepatoma cells in hormone-supplemented serum-free media.

1983 • 51 citations

Transferrin is required for early tooth morphogenesis

1984 • 49 citations

Differential immunocytochemical staining for fetuin and transferrin in the developing cortical plate

1984 • 46 citations

Transferrin: An early marker of oligodendrocytes in culture

1988 • 44 citations

Muscular Dystrophy, Biomedical Aspects.

1984 • 43 citations

Effect of iron and transferrin on pure oligodendrocytes in culture; characterization of a high-affinity transferrin receptor at different ages

1987 • 39 citations

Sequence of the chicken ovotransferrin gene

1987 • 39 citations

Transferrin receptor function in hereditary hemochromatosis.

1984 • 39 citations

Chicken serum transferrin duplicates the myotrophic effects of sciatin on cultured muscle cells

1982 • 38 citations

POSTNATAL ONTOGENESIS OF ASTROCYTES

1986 • 33 citations

Myelin basic protein and transferrin characterize different subpopulations of oligodendrocytes in rat primary glial cultures

1988 • 33 citations

Synthesis of the transferrin receptor by cultures of embryonic chicken spinal neurons.

1985 • 32 citations

Regulation of neuroblast proliferation by hormones and growth factors in chemically defined medium

1988 • 32 citations

The structural gene for transferrin (TF) maps to 3q21----3qter.

1984 • 31 citations

Chick embryo spinal cord neurons synthesize a transferrin‐like myotrophic protein

1983 • 31 citations

Chromosomal localization of human lactotransferrin gene (LTF) by in situ hybridization

1988 • 30 citations

An immunocytochemical study of the distribution of some plasma proteins within the developing forebrain of the pig with special reference to the neocortex

1985 • 27 citations

Necessity of transferrin for RNA synthesis in chick myotubes

1986 • 24 citations

Transferrin receptor regulation is coupled to intracellular ferritin in proliferating and differentiating HL60 leukemia cells

1985 • 23 citations

Immunocytochemical Localization of Transferrin and Mitochondrial Malate Dehydrogenase in the Developing Nervous System of the Rat

1988 • 23 citations

Studies on the mechanism of specificity of human natural killer cells for tumor cells: Correlation between target cell transferrin receptor expression and competitive activity

1985 • 20 citations

Specificity of chicken and mammalian transferrins in myogenesis

1985 • 20 citations

Cytochemical demonstration of ferric iron and fluorescence microscopy observations on ‘Gomori positive’ glia grownin vitro

1972 • 19 citations

Iron transfer from ferritin to transferrin

1987 • 15 citations

Receptor‐mediated uptake of labeled transferrin by embryonic chicken dorsal root ganglion neurons in culture

1985 • 12 citations

Transferrin in chick retina: distribution and location during development

1987 • 12 citations

Tumor-promoting, phorbol ester-induced phosphorylation of cell-surface transferrin receptors in human erythroleukemia cells.

1985 • 8 citations

A growth-promoting factor for human myeloid leukemia cells from horse serum identified as horse serum transferrin

1989 • 7 citations