Effect of Sustained Pyridoxine Treatment on Seizure Susceptibility and Regional Brain Amino Acid Levels in Genetically Epilepsy‐Prone BALB/c Mice

The Metabolic Basis of Inherited Disease

1990 • 4,327 citations

Chemical Nature of Synaptic Transmission in Vertebrates

1974 • 1,613 citations

Sensory Neuropathy from Pyridoxine Abuse

1983 • 695 citations

Possible Therapeutic Applications of Antagonists of Excitatory Amino acid Neurotransmitters

1985 • 558 citations

PYRIDOXINE DEPENDENCY: REPORT OF A CASE OF INTRACTABLE CONVULSIONS IN AN INFANT CONTROLLED BY PYRIDOXINE

1954 • 405 citations

Amino acid content of epileptogenic human brain: Focal versus surrounding regions

1972 • 258 citations

High‐Resolution ¹H NMR spectroscopy studies of extracts of human cerebral neoplasms

1992 • 212 citations

Combined use of 1H-NMR and GC-MS for metabolite monitoring and in vivo 1H-NMR assignments

1986 • 152 citations

CONVULSIONS IN YOUNG INFANTS AS A RESULT OF PYRIDOXINE (VITAMIN B6) DEFICIENCY

1954 • 142 citations

Neurotransmitter abnormalities as determinants of seizure susceptibility and intensity in the genetic models of epilepsy

1981 • 131 citations

Atypical presentations of pyridoxine‐dependent seizures: A treatable cause of intractable epilepsy in infants

1985 • 129 citations

Excitatory amino acids are elevated in human epileptic cerebral cortex

1988 • 128 citations

Subcortical mechanisms of audiogenic seizures

1966 • 125 citations

CONTENTS OF SEVERAL AMINO ACIDS IN THE CEREBELLUM, BRAIN STEM AND CEREBRUM OF THE ‘STAGGERER’, ‘WEAVER’ AND ‘NERVOUS’ NEUROLOGICALLY MUTANT MICE¹

1976 • 122 citations

Pyridoxine dependent seizures--a wider clinical spectrum.

1983 • 117 citations

Distribution of gamma-aminobutyric acid, glycine, glutamate and aspartate in the cochlear nucleus of the rat.

1978 • 112 citations

Amino acid abnormalities in epileptogenic foci

1981 • 107 citations

Vitamin B ₆ ‐dependent seizures

1978 • 107 citations

Neurotransmitters, Seizures, and Epilepsy III

1987 • 106 citations

¹H NMR detection of cerebral myo‐inositol

1985 • 105 citations

Increased levels of amino acid neurotransmitters in the inferior colliculus of the genetically epilepsy-prone rat

1988 • 96 citations

Neurobiology of Pyridoxine^a

1990 • 91 citations

FREE AMINO ACID LEVELS IN THE CEREBROSPINAL FLUID OF NORMAL HUMANS AND THEIR VARIATION IN CASES OF EPILEPSY AND SPIELMEYER‐VOGT‐BATTEN DISEASE

1974 • 85 citations

Distribution of putative amino acid transmitters, choline acetyltransferase and glutamate decarboxylase in the inferior colliculus

1979 • 82 citations

Occurrence of fits of an epileptiform nature in rats maintained for long periods on a diet deprived of vitamin B6

1940 • 80 citations

Neuronal response abnormalities in the inferior colliculus of the genetically epilepsy-prone rat

1986 • 75 citations

Brain regional amino acid levels in seizure susceptible rats: Changes related to sound-induced seizures

1986 • 70 citations

Recent Advances in Epilepsy

1989 • 70 citations

Glutamic acid and aspartic acid in subdivisions of the cochlear nucleus after auditory nerve lesion

1978 • 67 citations

Comparison of response properties of inferior colliculus neurons of two inbred mouse strains differing in susceptibility to audiogenic seizures.

1981 • 60 citations

Amino Acids in Human Epileptogenic Foci

1975 • 55 citations

Nuclear magnetic resonance study of regional metabolism after forebrain ischemia in rats.

1989 • 53 citations

PROVOCATION OF CEREBRAL SEIZURES BY DERANGEMENT OF THE NATURAL BALANCE BETWEEN GLUTAMIC ACID AND γ‐AMINOBUTYRIC ACID

1966 • 50 citations

Vitamin B6 Deficiency and Dependency in Man

1967 • 46 citations

Regulation and function of pyridoxal phosphate in CNS

1981 • 46 citations

EXPERIMENTAL STUDY OF THE EFFECTS PRODUCED BY LARGE DOSES OF VITAMIN B6

1942 • 46 citations

Neurotransmitter abnormality in rolling mouse Nagoya, an ataxic mutant mouse

1981 • 45 citations

SIGNS OF PYRIDOXINE DEPENDENCY MANIFEST AT BIRTH IN SIBLINGS

1963 • 42 citations

Pyridoxine-Dependent Seizures Requiring High Doses of Pyridoxine for Control

1979 • 42 citations

Cochlear Morphology of the Audiogenic-Seizure Susceptible (Ags) Or Genetically Epilepsy Prone Rat (Gepr)

1983 • 40 citations

Epilepsy and the concentrations of plasma amino acids in humans

1983 • 38 citations

Pyridoxine deficiency in swine with particular reference to anemia, epileptiform convulsions and fatty liver.

1943 • 38 citations

Henri gastaut and the marseilles school's contribution to the neurosciences

1984 • 37 citations

¹H NMR properties of N‐acetylaspartylglutamate in extracts of nervous tissue of the rat

1992 • 37 citations

Seizure Activity in Pyridoxine‐Deficient Adult Rats

1992 • 36 citations

Fundamental Mechanisms of Human Brain Function

1988 • 30 citations

Epilepsy-Prone Mice

1987 • 27 citations

The synthesis of pyridoxal phosphate in rat brain regions

1978 • 26 citations

Regional excitatory and inhibitory amino acid levels in epileptic El mouse brain

1990 • 24 citations

Increased concentrations of aspartic acid in the cerebrospinal fluid of patients with epilepsy and trigeminal neuralgia: an effect of medication?

2009 • 24 citations

On the 50th Anniversary of Our Society

1974 • 24 citations

Correlations between amino acid concentrations in brains of seizure-susceptible and seizure-resistant rats

1982 • 24 citations

The ultrastructure of the central nucleus of the inferior colliculus of the genetically epilepsy-prone rat

1988 • 20 citations

Amino Acid Changes in a Genetic Strain of Epileptic Beagle Dogs

1980 • 19 citations

Amino acid neurotransmitter alterations in three sublines of Rb mice differing by their susceptibility to audiogenic seizures

1990 • 13 citations

A Possible Role for Aspartic Acid in Neonatal Seizures

1981 • 10 citations

Epilepsy-Prone Mice Genetically Determined Sound-Induced Seizures

2003 • 9 citations

Plasma Amino Acid and Genetic Studies in Epilepsy

1989 • 7 citations

Quantitative proton nuclear magnetic resonance of plasma for screening hepatic metabolism during ethanol infusion in cats

1991 • 4 citations

Pathogenesis of Epilepsy

1869 • 2 citations