Lipid peroxidation as molecular mechanism of liver cell injury during reperfusion after ischemia

Neutrophils contribute to ischemia/reperfusion injury in rat liver in vivo

1990 • 739 citations

Neutrophil and Kupffer cell-induced oxidant stress and ischemia-reperfusion injury in rat liver

1991 • 663 citations

Noncyclooxygenase oxidative formation of a series of novel prostaglandins: Analytical ramifications for measurement of eicosanoids

1990 • 480 citations

Plasma glutathione and glutathione disulfide in the rat: regulation and response to oxidative stress.

1983 • 463 citations

Reactive oxygen and ischemia/reperfusion injury of the liver

1991 • 325 citations

Formation of novel non-cyclooxygenase-derived prostanoids (F2-isoprostanes) in carbon tetrachloride hepatotoxicity. An animal model of lipid peroxidation.

1992 • 319 citations

Functional inactivation of neutrophils with a Mac-1 (CD11b/CD18) monoclonal antibody protects against ischemia-reperfusion injury in rat liver

1993 • 290 citations

Role of free radicals in ischemic rat liver cell injury: prevention of damage by alpha-tocopherol administration.

1986 • 276 citations

Hydroperoxide‐Metabolizing Systems in Rat Liver

1975 • 266 citations

Oxidation in the NADP system and release of GSSG from hemoglobin‐free perfused rat liver during peroxidatic oxidation of glutathione by hydroperoxides

1972 • 257 citations

Superoxide Generation by Kupffer Cells and Priming of Neutrophils During Reperfusion After Hepatic Ischemia

1991 • 254 citations

Complement activates Kupffer cells and neutrophils during reperfusion after hepatic ischemia

1993 • 252 citations

Reactive oxygen species during ischemia-reflow injury in isolated perfused rat liver.

1988 • 237 citations

tert-Butyl hydroperoxide kills cultured hepatocytes by peroxidizing membrane lipids

1989 • 222 citations

Superoxide generation by neutrophils and Kupffer cells during in vivo reperfusion after hepatic ischemia in rats

1992 • 213 citations

Drug-induced lipid peroxidation in mice—II

1982 • 122 citations

The role of acrolein in allyl alcohol-induced lipid peroxidation and liver cell damage in mice

1987 • 122 citations

Trolox protects rat hepatocytes against oxyradical damage and the ischemic rat liver from reperfusion injury

1991 • 107 citations

Prevention of postischaemic lipid peroxidation and liver cell injury by iron chelation.

1989 • 107 citations

O2-. release by activated Kupffer cells upon hypoxia-reoxygenation

1991 • 103 citations

[83] Use of isolated perfused organs in hypoxia and ischemia/reperfusion oxidant stress

1990 • 102 citations

Oxidant stress during reperfusion of ischemic liver: No evidence for a role of xanthine oxidase

1988 • 97 citations

Enhanced sinusoidal glutathione efflux during endotoxin-induced oxidant stress in vivo

1992 • 77 citations

Quantitation of lipid peroxidation products by gas chromatography-mass spectrometry

1986 • 77 citations

Vascular Oxidant Stress and Hepatic Ischemia/Reperfusion Injury

1991 • 75 citations

Glutathione disulfide as index of oxidant stress in rat liver during hypoxia

1990 • 70 citations

NADH-Dependent reductive stress and ferritin-bound iron in allyl alcohol-induced lipid peroxidation in vivo: The protective effect of vitamin E

1992 • 63 citations

Breath ethane: A specific indicator of free-radical-mediated lipid peroxidation following reperfusion of the ischemic liver

1992 • 57 citations

Role of leukotriene B4 in the pathogenesis of hepatic ischemia-reperfusion injury in the rat

1992 • 56 citations

Creatine kinase-BB: A marker of liver sinusoidal damage in ischemia-reperfusion

1993 • 55 citations

Mechanism and prevention of ischemia-reperfusion-induced liver injury in rats

1991 • 55 citations

Inhibition of ischemia and reflow-induced liver injury by an SOD derivative that circulates bound to albumin

1990 • 52 citations

Quantitation of Hydroperoxy-Eicosatetraenoic Acids and Hydroxy-Eicosatetraenoic Acids as Indicators of Lipid Peroxidation Using Gas Chromatography-Mass Spectrometry

1993 • 48 citations

Lipid peroxidation is a nonparenchymal cell event with reperfusion after prolonged liver ischemia

1990 • 42 citations

Conjugated desferoxamine attenuates hepatic microvascular injury following ischemia/reperfusion.

1991 • 41 citations

Glutathione and ischemia-reperfusion injury in the perfused rat liver

1992 • 36 citations

Neutrophil chemotactic responses to aldehydes.

1982 • 35 citations

Pathophysiological consequences of enhanced intracellular superoxide formation in isolated perfused rat liver

1992 • 31 citations

Chemiluminescence-HPLC assay of phosphatidylcholine hydroperoxide generated by ischemia-reperfusion in the liver of rats

1992 • 30 citations

Role of lipid peroxidation in tissue injury after hepatic ischemia

1983 • 23 citations

Lipid peroxidation in transplanted rat liver.

1990 • 18 citations

Glutathione disulfide formation and lipid peroxidation during cardiac ischemia and reflow in the dog in vivo

1989 • 11 citations

Cytochemical studies of hydrogen peroxide generation in postischemic hepatocytes

1991 • 11 citations

Radiochemical quantitation of conjugated dienes during ischemia and reperfusion in the rat liver

1991 • 9 citations

Role of free Fe++ in lipid peroxidation during ischemia and reoxygenation of the liver

1987 • 6 citations

Effect of free radical scavengers in UW solution on pig liver preservation--a comparison with EC solution.

1990 • 5 citations

[Lipid peroxidation and free Fe2+ during ischemia and reoxygenation of the liver].

1987 • 3 citations