Experimental adenomas and carcinomas of the large intestine behave as distinct entities: Most carcinomas arisede novo in flat mucosa

ÆTIOLOGY OF ADENOMA—CARCINOMA SEQUENCE IN LARGE BOWEL

1978 • 409 citations

PRIMARY SEX-RATIO AND SIZE OF FAMILY

1970 • 366 citations

Relationship of Polyps of the Colon to Colonic Cancer

1958 • 283 citations

Morphogenesis of chemically induced neoplasms of the colon and small intestine in rats.

1974 • 257 citations

Induction of adenocarcinomas of the colon in mice by weekly injections of 1,2-dimethylhydrazine.

1973 • 229 citations

Carcinoma of the Colon and Antecedent Epithelium.

1971 • 213 citations

Mucous secretion in rat colonic mucosa during carcinogenesis induced by dimethylhydrazine. A morphological and histochemical study

1975 • 189 citations

Screening for Colon Cancer

1976 • 164 citations

A rat model for studying colonic cancer: Effect of cholestyramine on induced tumors

1973 • 161 citations

Polyunsaturated fat, cholesterol and large bowel tumorigenesis

1977 • 160 citations

Colon carcinogenesis in germ-free rats with 1,2-dimethylhydrazine and N-methyl-n'-nitro-N-nitrosoguanidine.

1974 • 139 citations

Induction by dimethylhydrazine of intestinal carcinoma in normal rats and rats fed high or low levels of vitamin A.

1973 • 136 citations

Effects of Dietary Fat Level and Dimethylhyd,razine on Fecal Acid and Neutral Sterol Excretion and Colon Carcinogenesis in Rats 2

1974 • 132 citations

Dimethylhydrazine-induced colon tumors in rats fed diets containing beef fat or corn oil with and without wheat bran

1977 • 131 citations

The epidemiology of colorectal polyps.Prevalence in New Orleans and International comparisons

1977 • 125 citations

Histogenesis and growth pattern of 1,2-dimethylhydrazine-induced rat colon adenocarcinoma.

1976 • 114 citations

Pathology of Intestinal Neoplasms and Other Lesions in Rats Exposed to Azoxymethane

1973 • 111 citations

The significance of nonspecific injury for colon carcinogenesis in rats.

1975 • 110 citations

Morphology and Morphogenesis of Experimental Epithelial Tumors of the Intestine

1975 • 109 citations

Brief Communication: Inhibition of Dimethylhydrazine-Induced Neoplasia of the Large Intestine by Disulfiram2

1975 • 103 citations

Morphogenesis of early 1, 2-dimethylhydrazine-induced lesions and latent period reduction of colon carcinogenesis in mice by a variant of Citrobacter freundii.

1977 • 88 citations

PROTECTIVE EFFECT OF DIETARY FIBRE AGAINST CHEMICALLY INDUCED BOWEL TUMOURS IN RATS

1978 • 84 citations

Morphological and autoradiographical investigations on experimental carcinogenesis and polyp development in the intestinal tract of rats and mice

1973 • 82 citations

Histogenesis of Symmetrical 1,2-Dimethylhydrazine-Induced Neoplasms of the Colon in the Mouse 2

1978 • 77 citations

Evaluation of Dimethylhydrazine Induced Tumours in Mice as a Model System for Colorectal Cancer

1973 • 76 citations

Cell proliferation in the descending colon of dimethylhydrazine treated rats and in dimethylhydrazine induced adenocarcinomata

1976 • 75 citations

The small carcinoma of the large bowel

1979 • 65 citations

Promotion of azoxymethane-induced colonic neoplasia by resection of the proximal small bowel.

1978 • 63 citations

Production of intestinal and other tumors by 1, 2-dimethylhydrazine dihydrochloride in mice. I. A light and transmission electron microscopic study of colonic neoplasms.

1976 • 63 citations

Early changes in the dynamics of crypt cell populations in mouse colon following administration of 1,2-dimethylhydrazine.

1977 • 61 citations

Antagonistic Action of Aerosols of Prostaglandins F2 and E2 on Bronchial Muscle Tone in Man

1972 • 61 citations

Inhibitory effects of selenium on 1,2- dimethylhydrazine and methylazoxymethanol colon carcinogenesis.Correlative studies on selenium effects on the mutagenicity and sister chromatid exchange rates of selected carcinogens

1977 • 61 citations

Brief Communication: Differential Susceptibility of Four Mouse Strains to Induction of Multiple Large-Bowel Neoplasms by 1,2-Dimethylhydrazine2

1974 • 56 citations

Tumorigenesis studies with 1,2-dimethylhydrazine dihydrochloride, hydrazine sulfate, and isonicotinic acid in golden hamsters.

1972 • 55 citations

Dietary Enhancement of Intestinal Carcinogenesis by Dimethylhydrazine in Rats

1973 • 50 citations

Influence of gonadal hormones and age on 1,2- dimethylhydrazine-induced colon carcinogenesis

1977 • 50 citations

Glycoprotein metabolism in normal proximal and distal rat colon and changes associated with 1,2-dimethylhydrazine-induced colonic neoplasia.

1978 • 49 citations

Surface changes in the descending colon of rats treated with dimethylhydrazine.

1977 • 48 citations

Erzeugung von Darmtumoren bei Mäusen durch 1,2-Dimethylhydrazin

1969 • 48 citations

Effects of diet on colon carcinogenesis and the immune system in rats treated with 1,2-dimethylhydrazine.

1978 • 48 citations

Effects of Cholestyramine on 1,2-Dimethylhydrazine-Induced Enteric Carcinoma in Germfree Rats

1975 • 47 citations

[The early stages of the 1,2-dimethylhydrazine-induced carcinoma of the small and large intestine of rats].

1970 • 46 citations

Colon carcinogenesis in germ-free rats with intrarectal 1,2-dimethylhydrazine and subcutaneous azoxymethane.

1976 • 43 citations

Experimental induction of tumors of the large bowel of rats: A review of the experience with 3–2′ dimethyl-4-aminobiphenyl

1971 • 41 citations

Colonic Neoplasms in Mice Produced with Six Injections of 1,2-Dimethylhydrazine

1977 • 40 citations

Cancerisierung des Rattendarmes durch 1,2-Dimethylhydrazin

1969 • 37 citations

Experimental investigations on the influence upon the chemical carcinogenesis

1976 • 32 citations

Ultrastructure of 1,2-Dimethylhydrazine-Induced Adenocarcinomas in Rat Colon2

1978 • 32 citations

Die Vorstufen des 1,2-Dimethylhydrazin-induzierten Dick- und D�nndarmcarcinoms der Ratte

1970 • 32 citations

Experimental investigations on the influence upon the chemical carcinogenesis

1974 • 28 citations

Dose Response to Intrarectal Administration of N -Methyl- N -nitrosourea and Histopathologic Evaluation of the Effect of Two Retinoids on Colon Lesions Induced in Rats 2

1978 • 28 citations

Glycosidases in Normal and Dimethylhydrazine-Treated Rats and Mice with Special Reference to the Colonic Tumours

1974 • 27 citations

Short Communications. Increased transfer ribonucleic acid methylase activity in tumours induced in the mouse colon by the administration of 1,2-dimethylhydrazine

1971 • 26 citations

Colonic protection from dimethylhydrazine by a high fiber diet.

1978 • 23 citations

Chemotherapy studies in autochthonous rat tumors intestinal cancer

1978 • 21 citations

Kinetics of changes in the crypts of the jejunal mucosa of dimethylhydrazine-treated rats

1978 • 21 citations

Inhibition of 1,2-Dimethylhydrazine-Induced Neoplasia of the Large Intestine in Female CF 1 Mice by Carbon Disulfide: Brief Communication 2

1978 • 20 citations

Immunologic Surveillance Against Chemically Induced Primary Colon Carcinoma in Rats 2

1978 • 19 citations

Corynebacterium parvum enhances colonic cancer in dimethylhydrazine-treated rats

1978 • 18 citations

Glycosidases Heterogeneity Among Dimethylhydrazine Induced Rat Colonic Tumours

1974 • 18 citations

Methylazoxymethanol acetate: induction of tumors and early effects of RNA synthesis.

1972 • 17 citations

Effect of BCG on Dimethylhydrazine Induction of Colon Tumors in Rats<xref ref-type="fn" rid="fn2">2</xref>

1975 • 17 citations

A new and advantageous model for colorectal cancer: its comparison with previous models for a common human disease

1978 • 17 citations

Intestinal carcinogenesis in rats using 1,2-dimethylhydrazine with or without degraded carrageenan

1975 • 16 citations

Stimulation of cell proliferation by histamine H receptors in dimethylhydrazine-induced adenocarcinomata

1978 • 16 citations

Pathogenesis of Rat Colon Carcinomas Induced by &lt;italic&gt;N&lt;/italic&gt;-Methyl-&lt;italic&gt;N&lt;/italic&gt;-nitrosourea&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;

1978 • 15 citations

Effect of Colostomy on Intestinal Carcinogenesis by Methylazoxymethanol Acetate in Rats

1978 • 14 citations

Lysosomal enzymes in macrophages of colonic tumors induced in rats by 1,2-dimethylhydrazine dihydrochloride.

1978 • 13 citations

Comparative morphological and histoautoradiographic study of multiple experimental intestinal tumours.

1974 • 12 citations

The induction of multiple large bowel neoplasms in mice.

1972 • 11 citations

New aspects of intestinal carcinogenesis by 1,2-dimethylhydrazine dihydrochloride (DMH) and the Influence of antilymphocyte globuline (ALG) on its on its progress

1978 • 11 citations

Generationszeitzyklus von 1,2-Dimethylhydrazin-induzierten Adenocarcinomen des Rattencolon

1971 • 10 citations

Effect of hepatotoxic or nephrotoxic agents on the induction of colon cancers in rats by 1,2-dimethylhydrazine

1977 • 10 citations

Der Einfluß der Hemicolektomie auf die Ausbildung von Dickdarmtumoren nach subkutaner Injektion von 1,2 — Dimethylhydrazin

1974 • 7 citations

Species variation in response to dimethylhydrazine

1976 • 6 citations

Effect of Unblocking Therapy and Levamisole on Primary Gastrointestinal Tumors in Rats: Immunologic and Histologic Correlation2

1978 • 6 citations

Experimental studies on polypogenesis and carcinogenesis of the large intestine

1974 • 5 citations

Effects of Oral and Rectal BCG Administration on Chemically-Induced Rat Intestinal Carcinoma

1977 • 4 citations

Induction of Colonic Adenocarcinomas by 1,2-Dimethylhydrazine Intrarectally Administered in Rats

1978 • 2 citations

Cell proliferation in dimethylhydrazine-induced colonie adenocarcinomata following cytotoxic drug treatment

1978 • 2 citations

Histological and autoradiographical studies on intestinal tumors of rat induced by oral administration of N,N'-2,7-fluorenylenebisacetamide.

1971 • 2 citations