Development of predictive pharmacokinetic simulation models for drug discovery

A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability.

1995 • 5,050 citations

The Merck index

1998 • 2,867 citations

Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells

1991 • 1,787 citations

Dissolution testing as a prognostic tool for oral drug absorption: immediate release dosage forms.

1998 • 1,060 citations

Physician's desk reference

1987 • 1,036 citations

Managing the drug discovery/development interface

1997 • 505 citations

Pharmaceutical innovation by the seven UK‐owned pharmaceutical companies (1964‐1985).

1988 • 467 citations

9-(1,3-Dihydroxy-2-propoxymethyl)guanine: a new potent and selective antiherpes agent

1983 • 338 citations

Estimating human oral fraction dose absorbed: a correlation using rat intestinal membrane permeability for passive and carrier-mediated compounds.

1988 • 290 citations

Anti-herpesvirus activity of the acyclic nucleoside 9-(1,3-dihydroxy-2-propoxymethyl)guanine

1983 • 262 citations

Absorption Potential: Estimating the Fraction Absorbed for Orally Administered Compounds

1985 • 218 citations

Mixing-Tank Model for Predicting Dissolution Rate Control of Oral Absorption

1986 • 145 citations

Simulation models to predict oral drug absorption from in vitro data

1997 • 108 citations

The absolute oral bioavailability of selected drugs.

1989 • 108 citations

Pharmacokinetic, Safety, and Antiviral Profiles of Oral Ganciclovir in Persons Infected with Human Immunodeficiency Virus: A Phase I/II Study

1995 • 107 citations

Prediction of dissolution–absorption relationships from a dissolution/Caco-2 system

1999 • 90 citations

Novel Approach to the Analysis of in Vitro–in Vivo Relationships**Presented in part at the Ninth Annual Meeting and Exposition of the American Association of Pharmaceutical Scientists, San Diego, CA, November 1994.

1996 • 83 citations

Ganciclovir absolute bioavailability and steady-state pharmacokinetics after oral administration of two 3000-mg/d dosing regimens in human immunodeficiency virus— and cytomegalovirus-seropositive patients

1995 • 82 citations

Saturable small intestinal drug absorption in humans: modeling and interpretation of cefatrizine data

1998 • 78 citations

Convolution-Based Approaches for in Vivo-in Vitro Correlation Modeling

1997 • 62 citations

Permeability characteristics of various intestinal regions of rabbit, dog, and monkey.

1992 • 58 citations

The effect of in vivo dissolution, gastric emptying rate, and intestinal transit time on the peak concentration and area-under-the-curve of drugs with different gastrointestinal permeabilities.

1999 • 49 citations

Pharmacokinetics of naproxen in the dog.

1981 • 39 citations

A new approach to modelling the relationship betweenin vitro andin vivo drug dissolution/absorption

1999 • 35 citations

Effect of Food on the Relative Bioavailability of Oral Ganciclovir

1996 • 34 citations

Selection of a derivative of the antiviral agent 9-[(1,3-dihydroxy-2-propoxy)-methyl]guanine (DHPG) with improved oral absorption.

1987 • 21 citations

Pharmacokinetic studies with atenolol in the dog

1983 • 18 citations

In Vitro Dissolution Tests Corresponding to the in Vivo Dissolution of Clarithromycin Tablets in the Stomach and Intestine.

1995 • 10 citations