Development of tolerance to the analgesic effect of clonidine in rats cross-tolerance to morphine

Regulation of noradrenaline release by presynaptic receptor systems

1977 • 1,482 citations

Inhibition of both noradrenergic and serotonergic neurons in brain by the α-adrenergic agonist clonidine

1975 • 1,010 citations

Noradrenergic neurons: Morphine inhibition of spontaneous activity

1974 • 433 citations

Involvement of α-receptors in clonidine-induced inhibition of transmitter release from central monoamine neurones

1973 • 202 citations

Analgesia produced by clonidine in mice and rats

1974 • 190 citations

Possible involvement of central adrenaline neurons in vasomotor and respiratory control. Studies with clonidine and its interactions with piperoxane and yohimbine

1974 • 184 citations

Effects of clonidine on morphine withdrawal signs in the rat

1975 • 177 citations

Behavioural and biochemical effects of 2‐(2,6‐dichlorophenylamino)‐2‐imidazoline hydrochloride (St 155) on the central nervous system

1969 • 156 citations

Clonidine antinociceptive activity: Effects of drugs influencing central monoaminergic and cholinergic mechanisms in the rat

1976 • 156 citations

Influence of morphine and naloxone on the release of noradrenaline from rat brain cortex slices

1974 • 149 citations

Observations on the neuropharmacology of morphine and morphinelike analgesia.

1960 • 143 citations

Sedative effects of α-sympathomimetic drugs and their antagonism by adrenergic and cholinergic blocking drugs

1971 • 134 citations

The Effects of Caffeine and Theophylline on Nociceptive Stimulation in the Rat

1973 • 104 citations

[Pharmacological effects of 2-(2,6-dichlorophenylamino)-2-imidazoline hydrochloride, a new, antihypertensive substance].

1966 • 100 citations

Ascending catecholamine systems and morphine analgesia

1975 • 83 citations

Aggressive behavior induced by large doses of 2-(2,6-dichlorphenylamino)-2-imidazoline hydrochloride (ST 155) in mice

1968 • 76 citations

Sleep produced by clonidine (2‐(2,6‐dichlorophenylamino)‐2‐imidazoline hydrochloride)

1971 • 75 citations

Morphine-induced inhibition of different pain responses in relation to the regional turnover of rat brain noradrenaline and dopamine

1975 • 69 citations

Depression by clonidine of shaking behaviour elicited by nalorphine in morphine-dependent rats

1977 • 48 citations

Influence of morphine and naloxone on the release of noradrenaline from rat cerebellar cortex slices

1975 • 47 citations

Tolerance and dependence after chronic administration of clonidine to the rat

1977 • 32 citations

Discontinuation of chronic clonidine treatment: Evidence for facilitated brain noradrenergic neurotransmission

1977 • 32 citations

Tolerance and Physical Dependence

1971 • 23 citations

Effects of alpha-adrenergic blocking agents on narcotic-induced analgesia.

1974 • 13 citations

The potential role of catecholamines in drug induced changes of central pain responses, with special emphasis on morphine effects in the rat

1976 • 7 citations

CLONIDINE INDUCED INHIBITION OF CENTRAL PAIN RESPONSES

1977 • 3 citations

Evaluation of the antinociceptive effects of 4,α-dimethyl-m-tyramine (H 77/77) in the rat

1976 • 3 citations