Celecoxib, a Cyclooxygenase 2 Inhibitor as a Potential Chemopreventive to UV-Induced Skin Cancer

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

1971 • 8,596 citations

Statistical Methods for Survival Data Analysis.

1993 • 2,960 citations

Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas

1994 • 2,553 citations

Suppression of Intestinal Polyposis in ApcΔ716 Knockout Mice by Inhibition of Cyclooxygenase 2 (COX-2)

1996 • 2,387 citations

Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2

1995 • 2,308 citations

Treatment of Colonic and Rectal Adenomas with Sulindac in Familial Adenomatous Polyposis

1993 • 1,739 citations

Increased expression of cyclooxygenase 2 occurs frequently in human lung cancers, specifically in adenocarcinomas.

1998 • 825 citations

Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines.

1993 • 710 citations

Cyclooxygenase-2 expression is up-regulated in human pancreatic cancer.

1999 • 692 citations

Cyclooxygenase-2 expression in human esophageal carcinoma.

1999 • 670 citations

Expression of Cyclooxygenase-1 and Cyclooxygenase-2 in Human Breast Cancer

1998 • 665 citations

COX-2 expression is induced by UVB exposure in human skin: implications for the development of skin cancer

1998 • 596 citations

Arachidonic Acid Oxygenation by COX-1 and COX-2

1999 • 519 citations

Increased cyclooxygenase-2 levels in carcinogen-induced rat colonic tumors

1996 • 438 citations

Effect of anti-inflammatory drugs on overall risk of common cancer: case-control study in general practice research database

2000 • 426 citations

Low-Dose Aspirin and Incidence of Colorectal Tumors in a Randomized Trial

1993 • 423 citations

Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, and indomethacin against ultraviolet light-induced skin carcinogenesis

1999 • 413 citations

Evidence for Involvement of NF-κB in the Transcriptional Control of COX-2 Gene Expression by IL-1β

1997 • 390 citations

Nonsteroidal Antiinflammatory Drugs and Breast Cancer

1996 • 352 citations

An overview of skin cancers

1995 • 348 citations

Reduction of UV-induced skin tumors in hairless mice by selective COX-2 inhibition

1999 • 334 citations

Cyclooxygenase-2 Overexpression Enhances Lymphatic Invasion and Metastasis in Human Gastric Carcinoma

1999 • 281 citations

Cyclooxygenase-2 gene expression in human breast cancer

1997 • 274 citations

Use of Nonsteroidal Anti-inflammatory Drugs and Incidence of Colorectal Cancer

1999 • 265 citations

Epidemiology of solar keratoses

2006 • 255 citations

Involvement of nuclear factor kB in the regulation of cyclooxygenase‐2 expression by interleukin‐1 in rheumatoid synoviocytes

1997 • 252 citations

Differential expression and regulation of cyclooxygenase-1 and -2 in two human breast cancer cell lines.

1996 • 244 citations

Size- and invasion-dependent increase in cyclooxygenase 2 levels in human colorectal carcinomas

1999 • 224 citations

Differential expression of prostaglandin h synthase isozymes during multistage carcinogenesis in mouse epidermis

1995 • 149 citations

Association between coronary heart disease and cancers of the breast, prostate, and colon.

1998 • 141 citations

Expression of cyclooxygenase-2 protein in gastric adenocarcinoma

1998 • 127 citations

Adverse effects of nonsteroidal anti-inflammatory drugs on the gastrointestinal system.

1998 • 126 citations

A Method for Bioassay of an Epidermal Chalone-Like Inhibitor

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Tumor Necrosis Factor-α Promotes Sustained Cyclooxygenase-2 Expression: Attenuation by Dexamethasone and NSAIDs

1997 • 101 citations

Relation of antioxidants and level of dietary lipid to epidermal lipid peroxidation and ultraviolet carcinogenesis.

1985 • 98 citations

INFLUENCE OF DIETARY OMEGA‐6, ‐3 FATTY ACID SOURCES ON THE INITIATION AND PROMOTION STAGES OF PHOTOCARCINOGENESIS

1992 • 91 citations

Ibuprofen-induced inhibition of cyclooxygenase isoform gene expression and regression of rat mammary carcinomas

1998 • 89 citations

Increased synthesis of high-molecular-weight cPLA2 mediates early UV-induced PGE2 in human skin

1996 • 87 citations

The 1994 Merck Frosst Award. Mechanisms of nonsteroidal anti-inflammatory drug (NSAID) induced gastrointestinal damage—potential for development of gastrointestinal tract safe NSAIDs

1994 • 85 citations

MODIFICATION OF MEMBRANE COMPOSITION, EICOSANOID METABOLISM, AND IMMUNORESPONSIVENESS BY DIETARY OMEGA‐3 AND OMEGA‐6 FATTY ACID SOURCES, MODULATORS OF ULTRAVIOLET‐CARCINOGENESIS

1991 • 69 citations

LAMP/FILTER SYSTEMS FOR SIMULATION OF SOLAR UV IRRADIANCE UNDER REDUCED ATMOSPHERIC OZONE

1975 • 57 citations

The protective effect of indomethacin on photocarcinogenesis in hairless mice

1995 • 48 citations

Inhibition of ultraviolet-B epidermal ornithine decarboxylase induction and skin carcinogenesis in hairless mice by topical indomethacin and triamcinolone acetonide.

1982 • 29 citations

Growth arrest of DMBA-induced mammary carcinogenesis with ibuprofen treatment in female Sprague-Dawley rats

1997 • 24 citations

[Non-steroidal anti-inflammatory drugs and cyclooxygenase-2 selectivity in gastroenterology].

1999 • 9 citations

Effects of systemic indomethacin on photocarcinogenesis in hairless mice

1995 • 7 citations