Bovine Insulin and Porcine or Human Insulin Prime Distinct CD4+ T Cell Subsets in C57BL/6 Mice

Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes

1993 • 1,087 citations

An improved colorimetric assay for cell proliferation and viability utilizing the tetrazolium salt XTT

1991 • 994 citations

Induction of T _H 1 and T _H 2 Immunity in Neonatal Mice

1996 • 671 citations

Production of interferon gamma, interleukin 2, interleukin 4, and interleukin 10 by CD4+ lymphocytes in vivo during healing and progressive murine leishmaniasis.

1991 • 528 citations

Simultaneous production of IL-2, IL-4, and IFN-gamma by activated human CD4+ and CD8+ T cell clones.

1988 • 509 citations

A new murine CD4+ T cell subset with an unrestricted cytokine profile.

1989 • 374 citations

Enhanced Dissociation of HLA-DR-Bound Peptides in the Presence of HLA-DM

1996 • 327 citations

Insulin‐specific T cells are a predominant component of islet infiltrates in pre‐diabetic NOD mice

1994 • 279 citations

Editing of the HLA-DR-peptide repertoire by HLA-DM.

1996 • 273 citations

Antigen-reactive T cell clones. I. Transcomplementing hybrid I-A-region gene products function effectively in antigen presentation.

1980 • 252 citations

Heterogeneity of single cell cytokine gene expression in clonal T cell populations.

1994 • 173 citations

Selective Activation of Th1‐ and Th2‐like Cells in vivo– Response to Human Collagen IV

1991 • 129 citations

Major histocompatibility complex (MHC) control of CD4 T cell subset activation. II. A single peptide induces either humoral or cell‐mediated responses in mice of distinct MHC genotype

1992 • 120 citations

Ir-gene control of immunogenicity of insulin and A-chain loop as a carrier determinant

1975 • 112 citations

Selective loss of antigen-specific Ir gene function in IA mutant B6.C-H-2bm12 is an antigen presenting cell defect.

1981 • 84 citations

Regulation of human insulin gene expression in transgenic mice

1986 • 82 citations

Generation, persistence, and modulation of Th0 effector cells: role of autocrine IL-4 and IFN-gamma.

1998 • 72 citations

Generation, Persistence, and Modulation of Th0 Effector Cells: Role of Autocrine IL-4 and IFN-γ

1998 • 56 citations

Functional CD4 T cell subset interplay in an intact immune system.

1993 • 53 citations

Inverse Ir gene control of the antibody and T cell proliferative responses to human basement membrane collagen.

1987 • 46 citations

Regulatory mechanisms in immune responses to heterologous insulins. II. Suppressor T cell activation associated with nonresponsiveness in H-2b mice.

1984 • 44 citations

Ir gene control of carrier recognition III.cooperative recognition of two or more carrier determinants on insulins of different lspecies

1977 • 44 citations

Tolerance induced by physiological levels of secreted proteins in transgenic mice expressing human insulin.

1989 • 15 citations

Comparison of the T cell receptors on insulin-specific hybridomas from insulin transgenic and nontransgenic mice. Loss of a subpopulation of self-reactive clones.

1992 • 15 citations

Helper T-cell clones that recognize autologous insulin are stimulated in nonresponder mice by pork insulin.

1988 • 12 citations