Total synthesis of (+)-monacolin K (mevinolin)

Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.

1980 • 1,607 citations

Synthesis of .alpha.,.beta.-unsaturated carbonyl compounds by palladium(II)-catalyzed dehydrosilylation of silyl enol ethers

1978 • 827 citations

Monacolin K, a new hypocholesterolemic agent produced by a Monascus species.

1979 • 667 citations

Monacolin K, a new hypocholesterolemic agent that specifically inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase.

1980 • 236 citations

A chiral total synthesis of compactin

1982 • 108 citations

Rapid and substantial lowering of human serum cholesterol by mevinolin (MK-803), an inhibitor of hydroxymethylglutaryl-coenzyme a reductase

1982 • 94 citations

Cram rule selectivity in the Lewis acid catalyzed cyclocondensation of chiral aldehydes. A convenient route to chiral systems of biological interest

1982 • 87 citations

8,9-Epoxyarachinodic acid: a cytochrome P-450 metabolite

1982 • 47 citations

Carbamate mediated 1,3-asymmetric induction. A stereoselective synthesis of acyclic 1,3-diol systems

1982 • 45 citations

Synthesis of the hexahydronaphthalene moiety of (.+-.)-compactin (ML-236B)

1982 • 44 citations

Mevinic acids and analogues: preparation of a key chiral intermediate

1982 • 41 citations

Structural modification of mevinolin

1982 • 37 citations

The total synthesis of (±) compactin and its natural (+) enantiomer

1982 • 27 citations

Synthesis and biological activity of the hexalin moiety of compactin (ML-236B)

1982 • 17 citations