DnaK as a thermometer: threonine-199 is site of autophosphorylation and is critical for ATPase activity.

Spectroscopic Determination of Tryptophan and Tyrosine in Proteins^*

1967 • 3,423 citations

Prediction of protein conformation

1974 • 3,327 citations

Speculations on the functions of the major heat shock and glucose-regulated proteins

1986 • 1,574 citations

Interaction of Hsp 70 with Newly Synthesized Proteins: Implications for Protein Folding and Assembly

1990 • 1,293 citations

Heat shock, from bacteria to man

1982 • 1,260 citations

Three-dimensional structure of the ATPase fragment of a 70K heat-shock cognate protein

1990 • 1,035 citations

Polypeptide chain binding proteins: Catalysts of protein folding and related processes in cells

1989 • 884 citations

Conserved features of eukaryotic hsp70 genes revealed by comparison with the nucleotide sequence of human hsp70.

1985 • 860 citations

Escherichia coli DnaJ and GrpE heat shock proteins jointly stimulate ATPase activity of DnaK.

1991 • 835 citations

Physiology of the bacterial cell : a molecular approach

1990 • 806 citations

Physiology of the bacterial cell — A molecular approach

1991 • 770 citations

Peptide Binding and Release by Proteins Implicated as Catalysts of Protein Assembly

1989 • 763 citations

Is hsp70 the cellular thermometer?

1991 • 586 citations

Production of abnormal proteins in E. coli stimulates transcription of ion and other heat shock genes

1985 • 521 citations

Major heat shock gene of Drosophila and the Escherichia coli heat-inducible dnaK gene are homologous.

1984 • 513 citations

Stress proteins in biology and medicine

1990 • 502 citations

The E. coli dnaK gene product, the hsp70 homolog, can reactivate heat-inactivated RNA polymerase in an ATP hydrolysis-dependent manner

1990 • 407 citations

Levels of major proteins of Escherichia coli during growth at different temperatures

1979 • 372 citations

DnaK, DnaJ, and GrpE heat shock proteins negatively regulate heat shock gene expression by controlling the synthesis and stability of sigma 32.

1990 • 356 citations

Similarity of the three-dimensional structures of actin and the ATPase fragment of a 70-kDa heat shock cognate protein.

1991 • 352 citations

T. Maniatis, E. F. Fritsch and J. Sambrook, Molecular Cloning: A Laboratory Manual, X + 545 S., 61 Abb., 28 Tab. Cold Spring Harbor, N. Y. 1982. Cold Spring Harbor Laboratory

1984 • 349 citations

Genetic control of heat-shock protein synthesis and its bearing on growth and thermal resistance in Escherichia coli K-12.

1982 • 322 citations

The dnaK protein of Escherichia coli possesses an ATPase and autophosphorylating activity and is essential in an in vitro DNA replication system.

1983 • 260 citations

Transient rates of synthesis of individual polypeptides in E. coli following temperature shifts

1978 • 257 citations

Sigma 32 synthesis can regulate the synthesis of heat shock proteins in Escherichia coli.

1987 • 249 citations

Interactions of bacteriophage and host macromolecules in the growth of bacteriophage lambda

1984 • 246 citations

Cellular defects caused by deletion of the Escherichia coli dnaK gene indicate roles for heat shock protein in normal metabolism

1989 • 234 citations

Escherichia coli dnaK null mutants are inviable at high temperature

1987 • 231 citations

Identity of the immunoglobulin heavy-chain-binding protein with the 78,000-dalton glucose-regulated protein and the role of posttranslational modifications in its binding function.

1988 • 211 citations

Function of DnaJ and DnaK as chaperones in origin-specific DNA binding by RepA

1991 • 204 citations

Induction of a heat shock-like response by unfolded protein in Escherichia coli: dependence on protein level not protein degradation.

1989 • 180 citations

Induction of the heat shock regulon does not produce thermotolerance in Escherichia coli.

1987 • 177 citations

Heat shock protein GroE of Escherichia coli: key protective roles against thermal stress.

1988 • 171 citations

Altering the conserved nucleotide binding motif in the Salmonella typhimurium MutS mismatch repair protein affects both its ATPase and mismatch binding activities.

1991 • 164 citations

Murine 86- and 84-kDa Heat Shock Proteins, cDNA Sequences, Chromosome Assignments, and Evolutionary Origins

1989 • 154 citations

The 90-kDa heat shock protein (hsp-90) possesses an ATP binding site and autophosphorylating activity.

1991 • 147 citations

Mutations altering heat shock specific subunit of RNA polymerase suppress major cellular defects of E. coli mutants lacking the DnaK chaperone.

1990 • 146 citations

Characterization of the phosphorylation sites and the surrounding amino acid sequences of the p21 transforming proteins coded for by the Harvey and Kirsten strains of murine sarcoma viruses.

1982 • 135 citations

Practical protein chemistry : a handbook

1986 • 132 citations

Temperature-induced synthesis of specific proteins in Escherichia coli: evidence for transcriptional control

1980 • 129 citations

Purification and structure of the intact Ada regulatory protein of Escherichia coli K12, O6-methylguanine-DNA methyltransferase.

1985 • 124 citations

Delta dnaK52 mutants of Escherichia coli have defects in chromosome segregation and plasmid maintenance at normal growth temperatures

1989 • 117 citations

The dnaK gene of Escherichia coli functions in initiation of chromosome replication

1988 • 113 citations

The activity of sigma 32 is reduced under conditions of excess heat shock protein production in Escherichia coli.

1989 • 109 citations

Reconstitution of a nine-protein system that initiates bacteriophage λ DNA replication

1989 • 98 citations

Functional domains of the Escherichia coli dnaK heat shock protein as revealed by mutational analysis

1989 • 82 citations

Transcriptional regulation of the heat-shock response: a plant perspective

1991 • 81 citations

Identity of the Immunoglobulin Heavy-Chain-Binding Protein with the 78,000-Dalton Glucose-Regulated Protein and the Role of Posttranslational Modifications in Its Binding Function

1988 • 73 citations

A member of the Hsp70 family is localized in mitochondria and resembles Escherichia coli DnaK.

1989 • 71 citations

Tyrosine 264 in the recA protein from Escherichia coli is the site of modification by the photoaffinity label 8-azidoadenosine 5'-triphosphate.

1985 • 61 citations

Escherichia coli DnaK and GrpE heat shock proteins interact both in vivo and in vitro

1989 • 61 citations

Practical Protein Chemistry-A Handbook

1986 • 57 citations

Phosphorylation of the major heat shock protein of Dictyostelium discoideum.

1982 • 45 citations

Nucleotide sequence of the cDNA of a bovine 70 kilodalton heat shock cognate protein

1990 • 34 citations

Effect of bacteriophage M13 infection on phosphorylation of dnaK protein and other Escherichia coli proteins

1987 • 26 citations

Interaction of DnaK with ATP: Binding, hydrolysis and Ca+2-stimulated autophosphorylation

1990 • 19 citations

Phosphorylation of glutaminyl-tRNA synthetase and threonyl-tRNA synthetase by the gene products of dnaK and dnaJ in Escherichia coli K-12 cells

1989 • 15 citations

Biochemical properties of the Escherichia coli dnaK heat shock protein and its mutant derivatives

1989 • 8 citations

Phosphorylation of the Major Heat Shock Protein of Dictyostelium discoideum

1982 • 8 citations