The present status of malaria chemotherapy: Mefloquine, a novel antimalarial

Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique

1979 • 2,481 citations

Space-Time Relationships in Somesthetic Localization

1956 • 859 citations

Observations on Two Plasmodium Falciparum Infections with an Abnormal Response to Chloroquine

1961 • 263 citations

Spectrophotometric Studies of the Interaction of Chloroquine with Deoxyribonucleic Acid

1965 • 207 citations

Mefloquine (WR 142,490) in the Treatment of Human Malaria

1975 • 172 citations

2,4,7-Triamino-6-ortho-substituted Arylpteridines. A New Series of Potent Antimalarial Agents

1967 • 155 citations

Antimalarials. 7. Bis(trifluoromethyl)-.alpha.-(2-piperidyl)-4-quinolinemethanols

1971 • 152 citations

Reactions of quinine, chloroquine, and quinacrine with DNA and their effects on the DNA and RNA polymerase reactions.

1966 • 149 citations

Chloroquine-resistant Plasmodium falciparum malaria in Kenya

1979 • 130 citations

3. TOXICITY OF PRIMAQUINE IN CAUCASIANS

1952 • 118 citations

Kinetics of a new antimalarial, mefloquine

1979 • 102 citations

Evidence for intercalation of chloroquine into DNA

1966 • 97 citations

The treatment of malaria.

1976 • 95 citations

Studies on Modes of Action of Chloroquine, Quinacrine, and Quinine and on Chloroquine Resistance

1966 • 88 citations

Optical isomers of aryl-2-piperidylmethanol antimalarial agents. Preparation, optical purity, and absolute stereochemistry

1974 • 87 citations

Molecular structural effects involved in the interaction of quinolinemethanolamines with DNA. Implications for antimalarial action

1977 • 80 citations

Antimalarial Activities of Various 4-Quinolinemethanols with Special Attention to WR-142,490 (Mefloquine)

1978 • 77 citations

The suppression of malarial parasitaemia by pyrimethamine in combination with dapsone or sulphormethoxine

1969 • 73 citations

Single-dose therapy of falciparum malaria with mefloquine or pyrimethamine-sulfadoxine.

1979 • 73 citations

The chemotherapy of rodent malaria, XXVIII

1977 • 71 citations

Chloroquine-Resistant Falciparum Malaria From Africa

1979 • 61 citations

Prophylactic activity of mefloquine hydrochloride (WR 142490) in drug-resistant malaria.

1974 • 59 citations

The chemotherapy of rodent malaria, XXVII Studies on mefloquine (WR 142,490)

1977 • 58 citations

Sequential treatment with quinine and mefloquine or quinine and pyrimethamine-sulfadoxine for falciparum malaria.

1977 • 55 citations

Studies of the disposition and metabolism of mefloquine HCl (WR 142,490), a quinolinemethanol antimalarial, in the rat. Limited studies with an analog, WR 30,090.

1975 • 54 citations

Mefloquine, a clinically useful quinolinemethanol antimalarial which does not significantly bind to DNA

1975 • 52 citations

The inhibitory effect of a drug combination on the development of mefloquine resistance inPlasmodium berghei

1980 • 52 citations

Laboratory evaluation of the photoxic potency of quinolylmethanols

1968 • 51 citations

New Experimental Antimalarial Drugs

1979 • 49 citations

Clinical testing of new antimalarial compounds.

1974 • 42 citations

Quantitation of the Antimalarial Agent, Mefloquine, in Blood, Plasma, and Urine Using High-Pressure Liquid Chromatography

1977 • 41 citations

Recent developments in chromatography and electrophoresis

1981 • 41 citations

Quarterly Progress Reports

1955 • 37 citations

Chloroquine Resistance in Malaria: Accessibility of Drug Receptors to Mefloquine

1979 • 35 citations

The absorption, distribution, and excretion in mice of the antimalarial mefloquine, erythro-2,8-bis(trifluoromethyl)-alpha-(2-piperidyl)-4-quinolinemethanol hydrochloride.

1978 • 35 citations

Falciparum malaria cured by quinine followed by sulfadoxine-pyrimethamine.

1975 • 33 citations

Single-Dose Therapy of Falciparum Malaria Using Pyrimethamine in Combination with Diformyldapsone or Sulfadoxine *

1976 • 33 citations

The chemotherapy of rodent malaria, XXI

1975 • 31 citations

The effects of mefloquine on

1979 • 30 citations

Chloroquine-resistant falciparum malaria from Africa

1979 • 26 citations

GLC Determination of Whole Blood Antimalarial Concentrations

1979 • 25 citations

Structure and Antimalarial Activity o Aminoalcohols and 2-(p-Chlorophenyl)-2-(4-piperidyl)tetrahydrofuran

1971 • 24 citations

The Army Malaria Research Program

1969 • 21 citations

Possible Chloroquine-Resistant Plasmodium Falciparum in Nigeria

1979 • 17 citations

Difference in antimalarial activity between certain amino alcohol diastereomers

1976 • 16 citations

Malaria suppression with fortnightly doses of pyrimethamine with sulfadoxine in the Gambia.

1970 • 16 citations

Analysis of Hydrophobic Amine Antimalarials in Biological Fluids with The Plastic Ion-Selective Electrode

1979 • 15 citations

Effect of ring and side chain substituents on the binding of naphthothiopheneethanolamines to deoxyribonucleic acid. Spectrophotometric studies

1973 • 14 citations

Complex formation between naphthothiopheneethanolamines and deoxyribonucleic acids

1975 • 13 citations

Comparison of diaminodiphenylsulphonepyrimethamine and sulfadoxine-pyrimethamine combinations in the treatment of falciparum malaria in Thailand

1975 • 13 citations

Further side-chain modification of antimalarial phenanthrene amino alcohols

1973 • 12 citations

Conformational studies of a family of related antimalarial phenanthrene amino alcohols

1977 • 12 citations

[Sulfadoxine-pyrimethamine resistant falciparum malaria from Cambodia].

1980 • 9 citations

¹⁴C‐labeled antimalarials. I. Synthesis of dl‐erythro‐ and threo‐α(2‐piperidyl)‐2,8‐bis(trifluoromethyl)‐4‐quinolinemethanol‐α‐¹⁴C

1980 • 6 citations

Some promising leads in experimental anti-malarial drugs.

1979 • 1 citations