Ligand-induced Conformational Changes in the Apical Domain of the Chaperonin GroEL

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Protein folding in the cell

1992 • 4,138 citations

The crystal structure of the bacterial chaperonln GroEL at 2.8 Å

1994 • 1,322 citations

Homologous plant and bacterial proteins chaperone oligomeric protein assembly

1988 • 1,316 citations

Chaperonin-mediated protein folding at the surface of groEL through a 'molten globule'-like intermediate

1991 • 853 citations

Reconstitution of active dimeric ribulose bisphosphate carboxylase from an unfolded state depends on two chaperonin proteins and Mg-ATP

1989 • 737 citations

GroE heat-shock proteins promote assembly of foreign prokaryotic ribulose bisphosphate carboxylase oligomers in Escherichia coli

1989 • 703 citations

Residues in chaperonin GroEL required for polypeptide binding and release

1994 • 645 citations

Purification and properties of groE, a host protein involved in bacteriophage assembly

1979 • 426 citations

Chaperonin-facilitated refolding of ribulose bisphosphate carboxylase and ATP hydrolysis by chaperonin 60 (groEL) are potassium dependent

1990 • 384 citations

A new ultrasensitive method for the determination of proteolytic activity

1968 • 365 citations

Location of a folding protein and shape changes in GroEL–GroES complexes imaged by cryo-electron microscopy

1994 • 334 citations

Crystalline Rhodanese. I. Purification and Physicochemical Examination.

1953 • 313 citations

Nested cooperativity in the ATPase activity of the oligomeric chaperonin GroEL

1995 • 308 citations

Chaperonins facilitate the in vitro folding of monomeric mitochondrial rhodanese

1991 • 298 citations

The covalent and tertiary structure of bovine liver rhodanese

1978 • 292 citations

The reaction cycle of GroEL and GroES in chaperonin-assisted protein folding

1993 • 288 citations

Binding and hydrolysis of nucleotides in the chaperonin catalytic cycle: Implications for the mechanism of assisted protein folding

1993 • 266 citations

Purified chaperonin 60 (groEL) interacts with the nonnative states of a multitude of Escherichia coli proteins

1992 • 239 citations

ATP induces large quaternary rearrangements in a cage-like chaperonin structure

1993 • 212 citations

Hydrolysis of adenosine 5'-triphosphate by Escherichia coli GroEL: Effects of GroES and potassium ion

1993 • 192 citations

Symmetric Complexes of GroE Chaperonins as Part of the Functional Cycle

1994 • 190 citations

The Origins and Consequences of Asymmetry in the Chaperonin Reaction Cycle

1995 • 176 citations

On the role of groES in the chaperonin-assisted folding reaction. Three case studies.

1994 • 166 citations

Characterization of a Functional GroEL ₁₄ (GroES ₇ ) ₂ Chaperonin Hetero-Oligomer

1994 • 154 citations

Asymmetrical Interaction of GroEL and GroES in the ATPase Cycle of Assisted Protein Folding

1995 • 142 citations

Promotion of the in vitro renaturation of dodecameric glutamine synthetase from Escherichia coli in the presence of GroEL (chaperonin-60) and ATP

1992 • 139 citations

Two Lines of Allosteric Communication in the Oligomeric Chaperonin GroEL are Revealed by the Single Mutation Arg196→Ala

1994 • 107 citations

Affinity of chaperonin-60 for a protein substrate and its modulation by nucleotides and chaperonin-10

1994 • 92 citations

Functional Significance of Symmetrical Versus Asymmetrical GroEL-GroES Chaperonin Complexes

1995 • 81 citations

Hydrophobic Surfaces That Are Hidden in Chaperonin Cpn60 Can Be Exposed by Formation of Assembly-Competent Monomers or by Ionic Perturbation of the Oligomer

1995 • 80 citations

The stability and hydrophobicity of cytosolic and mitochondrial malate dehydrogenases and their relation to chaperonin‐assisted folding

1994 • 75 citations

Thermodynamic Partitioning Model for Hydrophobic Binding of Polypeptides by GroEL

1994 • 68 citations

Thermodynamic Partitioning Model for Hydrophobic Binding of Polypeptides by GroEL

1994 • 67 citations

Gas-phase sequencing after electroblotting on polyvinylidene difluoride membranes assigns correct molecular weights to myoglobin molecular weight markers

1989 • 63 citations

A mutation in GroEL interferes with protein folding by reducing the rate of discharge of sequestered polypeptides.

1992 • 54 citations

Effect of Divalent Cations on the Molecular Structure of the GroEL Oligomer

1994 • 51 citations

Characterization of a stable, reactivatable complex between chaperonin 60 and mitochondrial rhodanese.

1992 • 43 citations

Recombinant bovine rhodanese: purification and comparison with bovine liver rhodanese

1992 • 42 citations

Magnesium and Manganese Content of Halophilic Bacteria

1986 • 41 citations

Photoincorporation of 4,4'-Bis(1-anilino-8-naphthalenesulfonic Acid) into the Apical Domain of GroEL: Specific Information from a Nonspecific Probe

1995 • 37 citations

Inactive GroEL Monomers Can Be Isolated and Reassembled to Functional Tetradecamers That Contain Few Bound Peptides

1995 • 33 citations

ATP induces non-identity of two rings in chaperonin GroEL.

1994 • 33 citations

The Molecular Chaperonin cpn60 Displays Local Flexibility That Is Reduced after Binding with an Unfolded Protein

1995 • 30 citations

Improved design of one‐dimensional vertical polyacrylamide slab gel electrophoresis avoids lateral streaking

1986 • 29 citations

Effect of Free and ATP-bound Magnesium and Manganese Ions on the ATPase Activity of Chaperonin GroEL14

1995 • 26 citations

Correlation between the stability of the GroEL-protein ligand complex and the release mechanism.

1994 • 24 citations

The Chaperonin GroEL Is Destabilized by Binding of ADP

1995 • 22 citations

Bound substrate polypeptides can generally stabilize the tetradecameric structure of Cpn60 and induce its reassembly from monomers

1994 • 19 citations

Limited tryptic digestion near the amino terminus of bovine liver rhodanese produces active electrophoretic variants with altered refolding

1993 • 8 citations