Positive feedback between p53 and TRF2 during telomere-damage signalling and cellular senescence

In-gel digestion for mass spectrometric characterization of proteins and proteomes

2006 • 4,732 citations

Shelterin: the protein complex that shapes and safeguards human telomeres

2005 • 2,897 citations

A DNA damage checkpoint response in telomere-initiated senescence

2003 • 2,600 citations

TRF2 Protects Human Telomeres from End-to-End Fusions

1998 • 1,679 citations

Cellular Senescence in Cancer and Aging

2007 • 1,611 citations

Telomeres and human disease: ageing, cancer and beyond

2005 • 1,586 citations

Senescence in premalignant tumours

2005 • 1,394 citations

Evolutionarily Conserved and Nonconserved Cellular Localizations and Functions of Human SIRT Proteins

2005 • 1,305 citations

Telomere Shortening Triggers Senescence of Human Cells through a Pathway Involving ATM, p53, and p21CIP1, but Not p16INK4a

2004 • 1,246 citations

RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

1999 • 1,134 citations

A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity

2009 • 1,004 citations

Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1

2007 • 817 citations

Senescence Induced by Altered Telomere State, Not Telomere Loss

2002 • 787 citations

p53 isoforms can regulate p53 transcriptional activity

2005 • 767 citations

The Tumor Suppressor p53 Regulates Polarity of Self-Renewing Divisions in Mammary Stem Cells

2009 • 666 citations

Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres

2000 • 600 citations

Siah-1, SIP, and Ebi Collaborate in a Novel Pathway for β-Catenin Degradation Linked to p53 Responses

2001 • 586 citations

T-loop assembly in vitro involves binding of TRF2 near the 3' telomeric overhang

2001 • 521 citations

Telomeric localization of TRF2, a novel human telobox protein

1997 • 495 citations

Different telomere damage signaling pathways in human and mouse cells

2002 • 475 citations

Telomeres Acquire Embryonic Stem Cell Characteristics in Induced Pluripotent Stem Cells

2009 • 475 citations

Nuclear-cytoplasmic shuttling of APC regulates β-catenin subcellular localization and turnover

2000 • 472 citations

Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27Kip1 at G1 phase

2004 • 398 citations

Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology

2000 • 393 citations

Multiple C-Terminal Lysine Residues Target p53 for Ubiquitin-Proteasome-Mediated Degradation

2000 • 383 citations

Telomere dysfunction and tumour suppression: the senescence connection

2008 • 382 citations

Phosphorylation-Dependent Ubiquitination of Cyclin D1 by the SCFFBX4-αB Crystallin Complex

2006 • 336 citations

Erosion of the telomeric single-strand overhang at replicative senescence

2003 • 332 citations

Short Telomeres Limit Tumor Progression In Vivo by Inducing Senescence

2007 • 303 citations

p53 isoforms Δ133p53 and p53β are endogenous regulators of replicative cellular senescence

2009 • 295 citations

Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment

2007 • 283 citations

Spontaneous abnormalities in normal fibroblasts from patients with Li-Fraumeni cancer syndrome: aneuploidy and immortalization.

1990 • 256 citations

The ups and downs of p53: understanding protein dynamics in single cells

2009 • 237 citations

Siah-1 N-Terminal RING Domain Is Required for Proteolysis Function, and C-Terminal Sequences Regulate Oligomerization and Binding to Target Proteins

1999 • 234 citations

Lys63-Linked Polyubiquitination of IRAK-1 Is Required for Interleukin-1 Receptor- and Toll-Like Receptor-Mediated NF-κB Activation

2008 • 223 citations

Significant Role for p16INK4a in p53-Independent Telomere-Directed Senescence

2004 • 219 citations

XPF nuclease-dependent telomere loss and increased DNA damage in mice overexpressing TRF2 result in premature aging and cancer

2005 • 217 citations

BLM helicase-dependent transport of p53 to sites of stalled DNA replication forks modulates homologous recombination

2003 • 207 citations

TRF1 is degraded by ubiquitin-mediated proteolysis after release from telomeres

2003 • 200 citations

Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53‐dependent cellular senescence

2007 • 197 citations

Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR

2008 • 177 citations

The molecular programme of tumour reversion: the steps beyond malignant transformation

2009 • 176 citations

POT1 and TRF2 Cooperate To Maintain Telomeric Integrity

2005 • 169 citations

Exploring Mechanisms of the DNA-Damage Response: p53 Pulses and their Possible Relevance to Apoptosis

2007 • 135 citations

SIAH-1 promotes apoptosis and tumor suppression through a network involving the regulation of protein folding, unfolding, and trafficking: Identification of common effectors with p53 and p21 ^Waf1

1999 • 114 citations

p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice

2009 • 98 citations

The cellular level of telomere dysfunction determines induction of senescence or apoptosisin vivo

2005 • 88 citations

Direct Ubiquitination of β-Catenin by Siah-1 and Regulation by the Exchange Factor TBL1

2010 • 85 citations

p53 Suppresses the c-Myb-induced Activation of Heat Shock Transcription Factor 3

2000 • 83 citations

Small Molecule Antagonists of the MDM2 Oncoprotein as Anticancer Agents

2005 • 68 citations

Role of the TRF2 Telomeric Protein in Cancer and Aging

2006 • 61 citations

High Precision NMR Structure and Function of the RING-H2 Finger Domain of EL5, a Rice Protein Whose Expression Is Increased upon Exposure to Pathogen-derived Oligosaccharides

2003 • 60 citations

Lack of TRF2 in ALT cells causes PML-dependent p53 activation and loss of telomeric DNA

2007 • 50 citations

Using mass spectrometry to identify ubiquitin and ubiquitin‐like protein conjugation sites

2009 • 49 citations

Determining the influence of telomere dysfunction and DNA damage on stem and progenitor cell aging – what markers can we use?

2008 • 48 citations

The Shelterin Protein TRF2 Inhibits Chk2 Activity at Telomeres in the Absence of DNA Damage

2009 • 46 citations

Schedule-Dependent Synergy between the Heat Shock Protein 90 Inhibitor 17-(Dimethylaminoethylamino)-17-Demethoxygeldanamycin and Doxorubicin Restores Apoptosis to p53-Mutant Lymphoma Cell Lines

2006 • 39 citations

Functional Diversity of Human Protection of Telomeres 1 Isoforms in Telomere Protection and Cellular Senescence

2007 • 38 citations

Normal p53 Function in Primary Cells Deficient for Siah Genes

2002 • 35 citations