Sequential change of the hypervariable region of the hepatitis C virus genome in acute infection

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Isolation of a cDNA cLone Derived from a Blood-Borne Non-A, Non-B Viral Hepatitis Genome

1989 • 6,910 citations

Avoiding false positives with PCR

1989 • 3,564 citations

An Assay for Circulating Antibodies to a Major Etiologic Virus of Human Non-A, Non-B Hepatitis

1989 • 3,401 citations

Genetic organization and diversity of the hepatitis C virus.

1991 • 1,717 citations

Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis.

1990 • 1,208 citations

Evidence for immune selection of hepatitis C virus (HCV) putative envelope glycoprotein variants: potential role in chronic HCV infections.

1992 • 712 citations

Gene mapping of the putative structural region of the hepatitis C virus genome by in vitro processing analysis.

1991 • 636 citations

Variable and hypervariable domains are found in the regions of HCV corresponding to the flavivirus envelope and NS1 proteins and the pestivirus envelope glycoproteins

1991 • 611 citations

Nucleotide sequence and mutation rate of the H strain of hepatitis C virus.

1991 • 609 citations

The 5'-terminal sequence of the hepatitis C virus genome.

1990 • 481 citations

Nucleotide sequence of the genomic RNA of hepatitis C virus isolated from a human carrier: comparison with reported isolates for conserved and divergent regions

1991 • 476 citations

Neutralization of the AIDS Retrovirus by Antibodies to a Recombinant Envelope Glycoprotein

1986 • 362 citations

Hypervariable regions in the putative glycoprotein of hepatitis C virus

1991 • 353 citations

The degree of variability in the amino terminal region of the E2/NS1 protein of hepatitis C virus correlates with responsiveness to interferon therapy in viremic patients

1992 • 295 citations

Non-A, non-B hepatitis specific antibodies directed at host-derived epitope: implication for an autoimmune process

1990 • 226 citations

Marked sequence diversity in the putative envelope proteins of hepatitis C viruses

1992 • 177 citations

Structural proteins of hog cholera virus expressed by vaccinia virus: further characterization and induction of protective immunity

1991 • 166 citations

Evolution of sequences encoding the principal neutralization epitope of human immunodeficiency virus 1 is host dependent, rapid, and continuous.

1990 • 143 citations