Formation of granular cytoplasmic aggregates in COS7 cells expressing mutant Cu/Zn superoxide dismutase associated with familial amyotrophic lateral sclerosis

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1993 • 6,762 citations

Motor Neuron Degeneration in Mice that Express a Human Cu,Zn Superoxide Dismutase Mutation

1994 • 3,959 citations

pEF-BOS, a powerful mammalian expression vector

1990 • 1,641 citations

ALS-Linked SOD1 Mutant G85R Mediates Damage to Astrocytes and Promotes Rapidly Progressive Disease with SOD1-Containing Inclusions

1997 • 1,313 citations

Aggregation of Mutant Cu/Zn Superoxide Dismutase Proteins in a Culture Model of ALS

1997 • 355 citations

A general and fast method to generate multiple site directed mutations

1992 • 219 citations

Mutations in all five exons of SOD‐1 may cause ALS

1998 • 150 citations

Pathological characterization of astrocytic hyaline inclusions in familial amyotrophic lateral sclerosis.

1997 • 113 citations

Identification of a novel S0D1 mutation in an apparently sporadic amyotrophic lateral sclerosis patient and the detection of lle113Thr in three others

1994 • 88 citations

Hereditary Amyotrophic Lateral Sclerosis

1972 • 88 citations

A Novel Mutation in Cu/Zn Superoxide Dismutase Gene in Japanese Familial Amyotrophic Lateral Sclerosis

1994 • 84 citations

Identification of a novel exon 4 SOD1 mutation in a sporadic amyotrophic lateral sclerosis patient

1994 • 47 citations

Instability of mutant Cu/Zn superoxide dismutase (Ala4Thr) associated with familial amyotrophic lateral sclerosis

1996 • 29 citations

Instability of expressed Cu/Zn superoxide dismutase with 2 bp deletion found in familial amyotrophic lateral sclerosis

1997 • 24 citations

A missense mutation in the SOD1 gene in patients with amyotrophic lateral sclerosis from the Kii Peninsula and its vicinity, Japan

1997 • 20 citations

[Familial amyotrophic lateral sclerosis with or without mutation of the Cu/Zn superoxide dismutase gene].

1995 • 10 citations

PRESENCE OF SUPEROXIDE DISMUTASE-1 (SOD1) IMMUNOREACTIVITY IN HYALINE INCLUSION BODIES OF THE SPINAL CORD NEURONS OF TRANSGENIC MICE FOR MUTANT SOD1 GENE

1996 • 4 citations