Transplantation of mesenchymal stem cells to enhance engraftment of hematopoietic stem cells

Multilineage Potential of Adult Human Mesenchymal Stem Cells

1999 • 20,447 citations

CLINICAL MANIFESTATIONS OF GRAFT-VERSUS-HOST DISEASE IN HUMAN RECIPIENTS OF MARROW FROM HL-A-MATCHED SIBLING DONOR,S

1974 • 3,686 citations

Bone Marrow Transplant

2001 • 3,479 citations

Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli

2002 • 3,149 citations

Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells

2004 • 2,658 citations

Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo

2002 • 2,268 citations

Heterotopic of bone marrow. Analysis of precursor cells for osteogenic and hematopoietic tissues.

1968 • 1,917 citations

HLA‐DR typing by PCR amplification with sequence‐specific primers (PCR‐SSP) in 2 hours: An alternative to serological DR typing in clinical practice including donor‐recipient matching in cadaveric transplantation

1992 • 1,846 citations

Mesenchymal progenitor cells in human umbilical cord blood

2000 • 1,599 citations

HETEROTOPIC TRANSPLANTS OF BONE MARROW

1968 • 1,575 citations

Suppression of allogeneic T-cell proliferation by human marrow stromal cells: implications in transplantation

2003 • 1,505 citations

Mesenchymal Stem Cells Inhibit and Stimulate Mixed Lymphocyte Cultures and Mitogenic Responses Independently of the Major Histocompatibility Complex

2003 • 1,361 citations

Identification of mesenchymal stem/progenitor cells in human first-trimester fetal blood, liver, and bone marrow

2001 • 1,337 citations

Characterization of cells with osteogenic potential from human marrow

1992 • 1,289 citations

Comparison of Multi-Lineage Cells from Human Adipose Tissue and Bone Marrow

2003 • 1,160 citations

Mesenchymal Stem Cells for Treatment of Therapy-Resistant Graft-versus-Host Disease

2006 • 1,126 citations

Rapid Hematopoietic Recovery After Coinfusion of Autologous-Blood Stem Cells and Culture-Expanded Marrow Mesenchymal Stem Cells in Advanced Breast Cancer Patients Receiving High-Dose Chemotherapy

2000 • 1,115 citations

Bone marrow-derived mesenchymal stem cells as vehicles for interferon-beta delivery into tumors.

2002 • 899 citations

Cotransplantation of HLA-Identical Sibling Culture-Expanded Mesenchymal Stem Cells and Hematopoietic Stem Cells in Hematologic Malignancy Patients

2005 • 796 citations

Ex vivo expansion and subsequent infusion of human bone marrow-derived stromal progenitor cells (mesenchymal progenitor cells): implications for therapeutic use.

1995 • 733 citations

Mesenchymal stem cells promote engraftment of human umbilical cord blood–derived CD34+ cells in NOD/SCID mice

2002 • 494 citations

Immunobiology of Human Mesenchymal Stem Cells and Future Use in Hematopoietic Stem Cell Transplantation

2005 • 454 citations

Human mesenchymal stem cells support unrelated donor hematopoietic stem cells and suppress T-cell activation

2004 • 451 citations

Mesenchymal stem cells home to injured tissues when co‐infused with hematopoietic cells to treat a radiation‐induced multi‐organ failure syndrome

2003 • 448 citations

A randomized trial comparing busulfan with total body irradiation as conditioning in allogeneic marrow transplant recipients with leukemia: a report from the Nordic Bone Marrow Transplantation Group

1994 • 341 citations

Stromal damage as consequence of high-dose chemo/radiotherapy in bone marrow transplant recipients

1999 • 281 citations

Donor CMV serologic status and outcome of CMV-seropositive recipients after unrelated donor stem cell transplantation: an EBMT megafile analysis

2003 • 248 citations

Bone marrow–derived mesenchymal stem cells remain host-derived despite successful hematopoietic engraftment after allogeneic transplantation in patients with lysosomal and peroxisomal storage diseases

1999 • 242 citations

Cotransplantation of human stromal cell progenitors into preimmune fetal sheep results in early appearance of human donor cells in circulation and boosts cell levels in bone marrow at later time points after transplantation

2000 • 235 citations

What's going on 造血器腫瘍 1)Human mesenchymal stem cells modulate allogeneic immune cell responses. Aggarwal S, Pittenger MF. Blood. 2005;105:1815-22. PMID:15494428. 2)Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells. Le Blanc K, Rasmusson I, Sundberg B, Gotherstrom C, Hassan M, Uzunel M, Ringden O. Lancet. 2004;363:1439-41. PMID:15121408--ヒト骨髄間葉系幹細胞のT細胞、NK細胞、樹状細胞への作用と関与する液性因子を検討した論文

2005 • 223 citations

Improved survival after unrelated donor bone marrow transplantation in children with primary immunodeficiency using a reduced-intensity conditioning regimen

2004 • 215 citations

Cotransplantation of human mesenchymal stem cells enhances human myelopoiesis and megakaryocytopoiesis in NOD/SCID mice

2003 • 193 citations

Peripheral Blood Stem Cell Transplantation From Unrelated Donors: A Comparison With Marrow Transplantation

1999 • 188 citations

Similar incidence of graft-versus-host disease using HLA-A, -B and -DR identical unrelated bone marrow donors as with HLA-identical siblings.

1995 • 186 citations

Dose Study of Thymoglobulin During Conditioning for Unrelated Donor Allogeneic Stem-Cell Transplantation

2004 • 179 citations

Nonexpanded primary lung and bone marrow–derived mesenchymal cells promote the engraftment of umbilical cord blood–derived CD34+ cells in NOD/SCID mice

2003 • 148 citations

Cyclosporine v methotrexate for graft-v-host disease prevention in patients given marrow grafts for leukemia: long-term follow-up of three controlled trials

1988 • 142 citations

Sirolimus and tacrolimus without methotrexate as graft-versus-host disease prophylaxis after matched related donor peripheral blood stem cell transplantation

2004 • 141 citations

Leukemia lineage-specific chimerism analysis is a sensitive predictor of relapse in patients with acute myeloid leukemia and myelodysplastic syndrome after allogeneic stem cell transplantation

2001 • 131 citations

Limited engraftment capacity of bone marrow–derived mesenchymal cells following T-cell–depleted hematopoietic stem cell transplantation

2000 • 109 citations

T CELL MIXED CHIMERISM IS SIGNIFICANTLY CORRELATED TO A DECREASED RISK OF ACUTE GRAFT-VERSUS-HOST DISEASE AFTER ALLOGENEIC STEM CELL TRANSPLANTATION 1

2001 • 101 citations

Failure of adult marrow-derived stem cells to generate marrow stroma after successful hematopoietic stem cell transplantation

2002 • 97 citations

Effect of chemotherapy for acute myelogenous leukemia on hematopoietic and fibroblast marrow progenitors

1997 • 83 citations

N-acetylcysteine for hepatic veno-occlusive disease after allogeneic stem cell transplantation

2000 • 79 citations

PANCREAS AFTER KIDNEY TRANSPLANTATION: A SIGNIFICANT RISK FACTOR FOR RENAL ALLOGRAFT LOSS

2004 • 75 citations

A Comparison of Nonmyeloablative and Reduced-Intensity Conditioning for Allogeneic Stem-Cell Transplantation

2004 • 72 citations

Bone marrow stromal function from patients after bone marrow transplantation.

1995 • 71 citations

Lack of Recovery of Murine Hematopoietic Stromal Cells After Irradiation-induced Damage

1974 • 56 citations

Allogenic stem cell transplantation for nonmalignant disorders using matched unrelated donors

2004 • 20 citations