Consensus-based recommendations for investigating clinical heterogeneity in systematic reviews

Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement

2009 • 78,446 citations

Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement

2009 • 53,927 citations

Measuring inconsistency in meta-analyses

2003 • 53,662 citations

Cochrane Handbook for Systematic Reviews of Interventions

2008 • 18,785 citations

Meta-analysis of Observational Studies in Epidemiology<SUBTITLE>A Proposal for Reporting</SUBTITLE>

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Introduction to Meta‐Analysis

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Introduction to Meta‐Analysis

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A simulation study of the number of events per variable in logistic regression analysis

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Cochrane Handbook for Systematic Reviews of Interventions, Version 5.1.0. The Cochrane Collaboration

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Systematic reviews: CRD's guidance for undertaking reviews in health care

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Quantitative Synthesis in Systematic Reviews

1997 • 2,428 citations

Updated Method Guidelines for Systematic Reviews in the Cochrane Collaboration Back Review Group

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Systematic reviews in health care: Investigating and dealing with publication and other biases in meta-analysis

2001 • 1,976 citations

Avoidable waste in the production and reporting of research evidence

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Importance of events per independent variable in proportional hazards regression analysis II. Accuracy and precision of regression estimates

1995 • 1,854 citations

Methods for Meta-Analysis in Medical Research

2000 • 1,803 citations

Explaining heterogeneity in meta-analysis: a comparison of methods

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2009 Updated Method Guidelines for Systematic Reviews in the Cochrane Back Review Group

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Controlling the risk of spurious findings from meta‐regression

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Systematic Reviews and Meta-Analysis

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Systematic Review: Why sources of heterogeneity in meta-analysis should be investigated

1994 • 947 citations

Meta‐Analysis Of Controlled Clinical Trials

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Geometric Interpretation of Gene Coexpression Network Analysis

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Importance of events per independent variable in proportional hazards analysis I. Background, goals, and general strategy

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Statistical heterogeneity in systematic reviews of clinical trials: a critical appraisal of guidelines and practice

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Methodologic guidelines for systematic reviews of randomized control trials in health care from the potsdam consultation on meta-analysis

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Avoidable Waste in the Production and Reporting of Research Evidence

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What is missing from descriptions of treatment in trials and reviews?

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Recent developments in meta‐analysis

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Meta-analysis of individual patient data from randomized trials: a review of methods used in practice

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Impact of allocation concealment on conclusions drawn from meta-analyses of randomized trials

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Individual patient‐ versus group‐level data meta‐regressions for the investigation of treatment effect modifiers: ecological bias rears its ugly head

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Testing Methodological Guidance on the Conduct of Narrative Synthesis in Systematic Reviews

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Understanding heterogeneity in meta-analysis: the role of meta-regression

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A comparison of summary patient-level covariates in meta-regression with individual patient data meta-analysis

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Performance of logistic regression modeling: beyond the number of events per variable, the role of data structure

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Meta‐analysis of continuous outcomes combining individual patient data and aggregate data

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How to review the evidence: systematic identification and review of the scientific literature

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Meta-regression detected associations between heterogeneous treatment effects and study-level, but not patient-level, factors

2004 • 231 citations

An empirical study of the effect of the control rate as a predictor of treatment efficacy in meta-analysis of clinical trials

1998 • 213 citations

Systematic Reviews to Support Evidence-Based Medicine: How to Review and Apply Findings of Healthcare Research.

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Taking healthcare interventions from trial to practice

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Investigating clinical heterogeneity in systematic reviews: a methodologic review of guidance in the literature

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Can meta-analysis help target interventions at individuals most likely to benefit?

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Meta-analysis and the exploration of causal mediating processes: A primer of examples, methods, and issues.

1996 • 164 citations

Frequency of Selecting Noise Variables in Subset Regression Analysis: A Simulation Study

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Attention should be given to multiplicity issues in systematic reviews

2008 • 129 citations

The Way in Which Intervention Studies Have “Personality” and why it is Important to Meta-Analysis

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Systematic reviews and knowledge translation

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Method guidelines for Cochrane Musculoskeletal Group systematic reviews.

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Testing overall and moderator effects in random effects meta‐regression

2010 • 95 citations

Can meta-analysis help target interventions at individuals most likely to benefit?

2005 • 91 citations

Comparative Effectiveness Review Methods: Clinical Heterogeneity

2010 • 88 citations

Knowledge for knowledge translation: The role of the Cochrane Collaboration

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Exploring Heterogeneity in Meta-Analysis

1999 • 73 citations

MULTIPLE-OUTCOME META-ANALYSIS OF CLINICAL TRIALS

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Bench-to-bedside review: Avoiding pitfalls in critical care meta-analysis – funnel plots, risk estimates, types of heterogeneity, baseline risk and the ecologic fallacy

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Interpreting and Evaluating Meta-Analysis

1995 • 66 citations

Phenomics: Expanding the Role of Clinical Evaluation in Genomic Studies

2010 • 50 citations

Predictive modeling and heterogeneity of baseline risk in meta-analysis of individual patient data

2001 • 48 citations

An overview of methods and empirical comparison of aggregate data and individual patient data results for investigating heterogeneity in meta‐analysis of time‐to‐event outcomes

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Return to a Note on Screening Regression Equations

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Creating clinically relevant knowledge from systematic reviews: the challenges of knowledge translation

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The Problem of Underestimating the Residual Error Variance in Forward Stepwise Regression

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DERIVING TREATMENT RECOMMENDATIONS FROM EVIDENCE WITHIN RANDOMIZED TRIALS The Role and Limitation of Meta-Analysis

1999 • 28 citations

Clinical heterogeneity was a common problem in Cochrane reviews of physiotherapy and occupational therapy

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An empirical study using permutation-based resampling in meta-regression

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CoPlot: A tool for visualizing multivariate data in medicine

2007 • 24 citations

Heterogeneity can impair the results of Cochrane meta‐analyses despite accordance with statistical guidelines

2008 • 7 citations

Deleted Work

1955 • 0 citations