Cyclooxygenase-2 as a therapeutic target

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

1976 • 3,613 citations

Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing.

1991 • 1,734 citations

The anti‐aggregating properties of vascular endothelium: interactions between prostacyclin and nitric oxide

1987 • 1,171 citations

Inhibition of apoptosis and prolongation of neutrophil functional longevity by inflammatory mediators

1993 • 726 citations

Rous-Whipple Award Lecture. Atherosclerosis: a defense mechanism gone awry.

1993 • 352 citations

Regulation of cyclooxygenase-2 expression in aortic smooth muscle cells.

1994 • 154 citations

The mitogen-activated protein kinase pathway can mediate growth inhibition and proliferation in smooth muscle cells. Dependence on the availability of downstream targets.

1997 • 150 citations

Vascular cell adhesion molecule-1 and smooth muscle cell activation during atherogenesis.

1993 • 87 citations

Differential Induction of Cyclooxygenase-2 in Human Arterial and Venous Smooth Muscle

1998 • 81 citations

Suppression of principal atherosclerotic mechanisms by prostacyclinc and other eicosanoids

1986 • 76 citations