Turnover of brush-border glycoproteins in human intestinal absorptive cells: Do lysosomes have a regulatory function?

Methods in Enzymology , Vol

1966 • 26,261 citations

Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents.

1978 • 2,146 citations

Mise en evidence des polysaccharides sur coupes fines en microscopie electronique

1967 • 1,751 citations

LYSOSOME FUNCTION IN THE REGULATION OF THE SECRETORY PROCESS IN CELLS OF THE ANTERIOR PITUITARY GLAND

1966 • 951 citations

Uptake and transport of macromolecules by the intestine. Possible role in clinical disorders.

1974 • 483 citations

Inhibition of the Lysosomal Pathway of Protein Degradation in Isolated Rat Hepatocytes by Ammonia, Methylamine, Chloroquine and Leupeptin

1979 • 466 citations

Use of colloidal gold particles in double-labeling immunoelectron microscopy of ultrathin frozen tissue sections.

1981 • 387 citations

MIGRATION OF GLYCOPROTEIN FROM THE GOLGI APPARATUS TO THE SURFACE OF VARIOUS CELL TYPES AS SHOWN BY RADIOAUTOGRAPHY AFTER LABELED FUCOSE INJECTION INTO RATS

1974 • 324 citations

Uptake and Transport of Macromolecules by the Intestine

1974 • 311 citations

Biogenesis of intestinal plasma membrane: Posttranslational route and cleavage of sucrase—isomaltase

1979 • 216 citations

FORMATION OF CELL COAT MATERIAL FOR THE WHOLE SURFACE OF COLUMNAR CELLS IN THE RAT SMALL INTESTINE, AS VISUALIZED BY RADIOAUTOGRAPHY WITH <scp>L</scp>-FUCOSE-3H

1970 • 190 citations

The possible role of pancreatic proteases in the turnover of intestinal brush border proteins

1975 • 161 citations

Inactivation of lysosomal function in normal cultured human fibroblasts by chloroquine

1973 • 153 citations

MIGRATION OF GLYCOPROTEIN FROM GOLGI APPARATUS TO CELL COAT IN THE COLUMNAR CELLS OF THE DUODENAL EPITHELIUM

1970 • 109 citations

Biosynthesis of sucrase-isomaltase. Purification and NH2-terminal amino acid sequence of the rat sucrase-isomaltase precursor (pro-sucrase-isomaltase) from fetal intestinal transplants.

1982 • 104 citations

Monoclonal antibodies to sucrase/isomaltase: probes for the study of postnatal development and biogenesis of the intestinal microvillus membrane.

1980 • 103 citations

The site of incorporation of sialic acid residues into glycoproteins and the subsequent fates of these molecules in various rat and mouse cell types as shown by radioautography after injection of [3H]N-acetylmannosamine. I. Observations in hepatocytes.

1981 • 99 citations

Synthesis of membrane glycoproteins in rat small-intestinal villus cells. Effect of colchicine on the redistribution of <scp>l</scp>-[1,5,6-3H]fucose-labelled membrane glycoproteins among Golgi, lateral basal and microvillus membranes

1979 • 93 citations

PASSAGE OF FUCOSE-3H LABEL FROM THE GOLGI APPARATUS INTO DENSE AND MULTIVESICULAR BODIES IN THE DUODENAL COLUMNAR CELLS AND HEPATOCYTES OF THE RAT

1971 • 86 citations

Synthesis of membrane glycoproteins in rat small-intestinal villus cells. Redistribution of <scp>l</scp>-[1,5,6-3H]-fucose-labelled membrane glycoproteins among Golgi, lateral basal and microvillus membranes in vivo

1979 • 78 citations

[5] Perturbation of the structure and function of the golgi complex by monovalent carboxylic ionophores

1983 • 75 citations

Distribution and content of microtubules in relation to the transport of lipid. An ultrastructural quantitative study of the absorptive cell of the small intestine.

1977 • 67 citations

Proton-translocating Mg2+-dependent ATPase activity in insulin-secretory granules

1982 • 67 citations

The effect of colchicine on the intracellular transport of 3H-fucose-labelled glycoproteins in the absorptive cells of cultured human small-intestinal tissue

1981 • 55 citations

Immuno-electronmicroscopical localization of a microvillus membrane disaccharidase in the human small-intestinal epithelium with monoclonal antibodies.

1985 • 51 citations

Biosynthesis of intestinal microvillar proteins. Role of the Golgi complex and microtubules

1983 • 50 citations

Cell‐free synthesis of the one‐chain precursor of a major intrinsic protein complex of the small‐intestinal brush border membrane (pro‐sucrase—isomaltase)

1981 • 48 citations

[9] Overview: Role of intracellular membrane systems in glycosylation of proteins

1983 • 46 citations

Effect of colchicine on rat small intestinal absorptive cells

1983 • 46 citations

Endocytosis in absorptive cells of cultured human small-intestinal tissue: Horseradish peroxidase, lactoperoxidase, and ferritin as markers

1981 • 44 citations

Effects of colchicine on the intestinal transport of endogenous lipid

1983 • 43 citations

Biosynthesis of intestinal microvillar proteins. Pulse-chase labelling studies on maltase-glucoamylase, aminopeptidase A and dipeptidyl peptidase IV

1983 • 37 citations

Antigen uptake in the gut: immunologic implications

1981 • 32 citations

Effect of colchicine on rat small intestinal absorptive cells

1983 • 30 citations

Differential sensitivity of intestinal brush border enzymes to pancreatic and lysosomal proteases

1976 • 29 citations

Purification and molecular characterization of rat intestinal brush border membrane dipeptidyl aminopeptidase IV

1983 • 28 citations

Endocytosis in absorptive cells of cultured human small-intestinal tissue: Effect of cytochalasin B and D

1982 • 26 citations

Effect of monensin on the Golgi apparatus of absorptive cells in the small intestine of the rat

1984 • 26 citations

Morphometry of the small intestinal enterocytes of the fasted rat and the effects of colchicine

1983 • 26 citations

Structure of Microvillar Enzymes in Different Phases of Their Life Cycles

1983 • 26 citations

Biosynthesis of intestinal microvillar proteins

1981 • 25 citations

The effect of chloroquine on lysosomal function and cell-coat glycoprotein transport in the absorptive cells of cultured human small-intestinal tissue

1981 • 23 citations

Fine structure and silver-staining patterns of lysosome-like bodies in absorptive cells of the small intestine in normal children and children with a lysosomal storage disease

1973 • 21 citations

Biosynthesis of intestinal microvillar proteins. Processing of aminopeptidase N by microsomal membranes

1983 • 21 citations

Effects of some antimalarials and related substances on intralysosomal proteolysis

1979 • 17 citations

Biosynthesis and Transport of Plasma Membrane Glycoproteins in the Rat Intestinal Epithelial Cell: Studies with Sucrase–Isomaltase

1983 • 15 citations

Effects of colchicine on the intestinal transport of endogenous lipid

1983 • 15 citations

Fucosidosis and I-cell disease: a fine structural and silver-staining study of abnormal inclusion bodies in small-intestinal cells.

1978 • 12 citations

The effects of colchicine on the distribution of glycoprotein-containing vesicles in epithelial cells of the murine colon

1983 • 10 citations

The effect of chloroquine on the intralysosomal degradation of cell-coat glycoproteins in the absorptive cells of cultured human small-intestinal tissue as shown by silver proteinate staining

1981 • 6 citations