Effects of angiotensin-converting enzyme and neutral endopeptidase inhibitors: influence of bradykinin

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1986 • 874 citations

Hoe 140 a new potent and long acting bradykinin‐antagonist: in vivo studies

1991 • 841 citations

Neutral endopeptidase 24.11: structure, inhibition, and experimental and clinical pharmacology.

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Human kidney "enkephalinase", a neutral metalloendopeptidase that cleaves active peptides

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Renal kallikrein-kinin system

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Role of renal endopeptidase 24.11 in kinin metabolism in vitro and in vivo

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1984 • 132 citations

Kinins, nitric oxide, and the hypotensive effect of captopril and ramiprilat in hypertension.

1992 • 121 citations

Kinins act on B₁ or B₂ receptors to release conjointly endothelium‐derived relaxing factor and prostacyclin from bovine aortic endothelial cells

1989 • 118 citations

Ultrastructural localization of angiotensin I-converting enzyme (EC 3.4.15.1) and neutral metalloendopeptidase (EC 3.4.24.11) in the proximal tubule of the human kidney.

1988 • 115 citations

Mechanism of natriuretic action of bradykinin

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Chronic kinin receptor blockade attenuates the antihypertensive effect of ramipril.

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Measurement of urinary kallikrein activity species differences in kinin production

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Effect of a kinin antagonist on the acute antihypertensive activity of enalaprilat in severe hypertension.

1988 • 97 citations

Effect of an angiotensin II and a kinin receptor antagonist on the renal hemodynamic response to captopril.

1991 • 89 citations

Complete differentiation between enkephalinase and angiotensin-converting enzyme inhibition by retro-thiorphan.

1983 • 86 citations

Kinin actions on renal papillary blood flow and sodium excretion.

1993 • 86 citations

Effects of converting enzyme inhibitor and neutral endopeptidase inhibitor on blood pressure and renal function in experimental hypertension.

1993 • 84 citations

Neurohormonal inhibition and hemodynamic unloading during prolonged inhibition of ANF degradation in patients with severe chronic heart failure.

1992 • 80 citations

Identification and characterization of neutral endopeptidase in endothelial cells from venous or arterial origins.

1992 • 79 citations

Micropuncture evidence of rapid hydrolysis of bradykinin by rat proximal tubule

1976 • 74 citations

Binding of [3H]bradykinin in isolated nephron segments of the rabbit

1984 • 73 citations

Urinary cGMP as biological marker of the renal activity of atrial natriuretic factor

1988 • 69 citations

Atrial natriuretic factor-potentiating and antihypertensive activity of SCH 34826. An orally active neutral metalloendopeptidase inhibitor.

1990 • 64 citations

Production of cyclic GMP via activation of B1 and B2 kinin receptors in cultured bovine aortic endothelial cells.

1992 • 62 citations

Increased vascular responsiveness to bradykinin in kidneys of spontaneously hypertensive rats. Effect of N omega-nitro-L-arginine.

1991 • 60 citations

A 94-kDa protein, identified as neutral endopeptidase-24.11, can inactivate atrial natriuretic peptide in the vascular endothelium.

1992 • 59 citations

The role of B1- and B2-kinin receptors in the renal tubular and hemodynamic response to bradykinin

1992 • 55 citations

Evidence that intrarenal bradykinin plays a role in regulation of renal function

1993 • 53 citations

Repression of angiotensin II and potentiation of bradykinin contribute to the synergistic effects of dual metalloprotease inhibition in heart failure.

1995 • 53 citations

Na+ transport in isolated rat CCD: effects of bradykinin, ANP, clonidine, and hydrochlorothiazide

1991 • 52 citations

Effect of angiotensin-converting-enzyme inhibition on bradykinin metabolism by vascular endothelial cells

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Effects of Hoe 140, a bradykinin B₂‐receptor antagonist, on renal function in conscious normotensive rats

1992 • 46 citations

Bradykinin action on the efflux of luminal 22Na in the rat nephron.

1980 • 46 citations

Hypotensive and natriuretic effects of RB 105, a new dual inhibitor of angiotensin converting enzyme and neutral endopeptidase in hypertensive rats.

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Role of endogenous atrial natriuretic peptide in DOCA-salt hypertensive rats. Effects of a novel nonpeptide antagonist for atrial natriuretic peptide receptor.

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Interaction of ANP and bradykinin during endopeptidase 24.11 inhibition: renal effects

1990 • 36 citations

Role of endogenous atrial natriuretic peptide in regulating sodium excretion in spontaneously hypertensive rats. Effects of neutral endopeptidase inhibition.

1991 • 32 citations

Potentiation of the renal responses to bradykinin by inhibition of neutral endopeptidase 3.4.24.11 and angiotensin-converting enzyme in anesthetized dogs.

1994 • 26 citations

Effects of the Selective Neutral Endopeptidase Inhibitor, Retrothiorphan, on Renal Function and Blood Pressure in Conscious Normotensive Wistar and Hypertensive DOCA-Salt Rats

1992 • 23 citations

Effects of captopril on urinary excretion of prostaglandins and electrolytes in spontaneously hypertensive rats

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ANF and bradykinin synergistically inhibit transport in M-1 cortical collecting duct cell line

1992 • 19 citations

Kinins inhibit conductive Na+ uptake by rabbit inner medullary collecting duct cells

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1991 • 10 citations

Thiorphan-induced natriuresis in volume-expanded rats: Roles of endogenous atrial natriuretic factor and kinins

1991 • 5 citations