Therapeutic efficacy of the non-peptide AVP antagonist OPC-31260 in cirrhotic rats

Pathogenesis of Sodium and Water Retention in High-Output and Low-Output Cardiac Failure, Nephrotic Syndrome, Cirrhosis, and Pregnancy

1988 • 486 citations

[1-(.beta.-mercapto-.beta.,.beta.-cyclopentamethylenepropionic acid),2-(O-methyl)tyrosine]arginine-vasopressin and [1-(.beta.-mercapto-.beta.,.beta.-cyclopentamethylenepropionic acid)]arginine-vasopressin, two highly potent antagonists of the vasopressor response to arginine-vasopressin

1980 • 449 citations

Potential Role of Increased Sympathetic Activity in Impaired Sodium and Water Excretion in Cirrhosis

1982 • 354 citations

Characterization of a novel aquaretic agent, OPC‐31260, as an orally effective, nonpeptide vasopressin V₂ receptor antagonist

1992 • 350 citations

Pathogenesis of Sodium and Water Retention in High-Output and Low-Output Cardiac Failure, Nephrotic Syndrome, Cirrhosis, and Pregnancy

1988 • 333 citations

Role of Vasopressin in Abnormal Water Excretion in Cirrhotic Patients

1982 • 308 citations

Sympathetic nervous activity, renin‐angiotensin system and renal excretion of prostaglandin E₂ in cirrhosis. Relationship to functional renal failure and sodium and water excretion

1983 • 212 citations

Prognostic value of spontaneous hyponatremia in cirrhosis with ascites

1976 • 199 citations

Discovery, development, and some uses of vasopressin and oxytocin antagonists.

1989 • 154 citations

Evidence that renal prostaglandins are involved in renal water metabolism in cirrhosis

1984 • 137 citations

Vasopressin Analogs That Antagonize Antidiuretic Responses by Rats to the Antidiuretic Hormone

1981 • 114 citations

Vascular Effects of Arginine Vasopressin during Fluid Deprivation in the Rat

1981 • 112 citations

Interrelationship between cardiac output and vascular resistance as determinants of effective arterial blood volume in cirrhotic patients

1985 • 102 citations

Effect of arginine vasopressin antagonist on renal water excretion in glucocorticoid and mineralocorticoid deficient rats

1982 • 99 citations

Mechanism of Effect of Thoracic Inferior Vena Cava Constriction on Renal Water Excretion

1974 • 94 citations

Therapeutic efficacy of non-peptide ADH antagonist OPC-31260 in SIADH rats

1993 • 92 citations

Effect of V1-vasopressin receptor blockade on arterial pressure in conscious rats with cirrhosis and ascites

1991 • 82 citations

Role of vasopressin in impaired water excretion in conscious rats with experimental cirrhosis

1981 • 80 citations

Design of more potent antagonists of the antidiuretic responses to arginine-vasopressin

1982 • 78 citations

Synthetic antagonists of in vivo antidiuretic and vasopressor responses to arginine-vasopressin

1981 • 76 citations

Mechanisms of improvement of water and sodium excretion by immersion in decompensated cirrhotic patients

1983 • 75 citations

Mechanisms of portal hypertension-induced alterations in renal hemodynamics, renal water excretion, and renin secretion.

1976 • 71 citations

Potent and selective antagonists of the antidiuretic responses to arginine-vasopressin based on modifications of [1-(.beta.-mercapto-.beta.,.beta.-pentamethylenepropionic acid), 2-D-isoleucine, 4-valine]arginine-vasopressin at position 4

1984 • 70 citations

Blockade of the hydroosmotic effect of vasopressin normalizes water excretion in cirrhotic rats

1989 • 66 citations

Effect of vasopressin antagonist on water excretion in inferior vena cava constriction

1986 • 59 citations

Antagonists of the antidiuretic activity of vasopressin

1988 • 58 citations

Role of Antidiuretic Hormone in Impaired Urinary Dilution Associated with Chronic Bile-Duct Ligation

1980 • 54 citations

A Simple and Highly Sensitive Radioimmunoassay for 8-A : rginine Vasopressin in Human Plasma Using a Reversed-Phase C<SUB>18</SUB> Silica Column

1985 • 51 citations

Neurohypophyseal vasopressor principle: Vasopressor hormone as well as antidiuretic hormone?

1978 • 49 citations

Design of more potent and selective antagonists of the antidiuretic responses to arginine-vasopressin devoid of antidiuretic agonism

1982 • 49 citations

Hyponatremia and arginine vasopressin secretion in patients with refractory hepatic ascites undergoing peritoneovenous shunting

1983 • 47 citations

Metabolic Clearance Rate of Arginine Vasopressin in Patients With Cirrhosi

1992 • 27 citations

Natriuretic, diuretic and anti-arginine-vasopressin (ADH) effects of two analogs of oxytocin: [4-leucine]-oxytocin and [2,4-diisoleucine]-oxytocin.

1970 • 25 citations

4-Leucine-Oxytocin: Natriuretic, Diuretic, and Antivasopressin Polypeptide

1968 • 25 citations

SK&F 105494 is a potent antidiuretic hormone antagonist in the rhesus monkey (Macaca mulatta).

1988 • 22 citations

Chronic Blockade of Vasopressin Receptors in Rats

1986 • 22 citations

Vascular effects of arginine vasopressin, angiotensin II, and norepinephrine in adrenal insufficiency

1984 • 22 citations

Critical Differences Between Species in the In Vivo and In Vitro Renal Responses to Antidiuretic Hormone Antagonists

1983 • 21 citations

In vivo diuretic effect of a new non-peptide arginine vasopressin antagonist, OPC-31260, in conscious rats

1994 • 20 citations

An investigation of the natriuretic, antidiuretic and oxytocic actions of neurohypophysial hormones and related peptides: delineation of separate mechanisms of action and assessment of molecular requirements.

1976 • 19 citations

Antidiuretic Hormone and Renal Function after Water Loading in Patients with Cirrhosis of the Liver

1991 • 18 citations

Prevention of hyponatraemia and cerebral oedema by the vasopressin antagonist d/CH2/5Tyr/Et/VAVP in rats treated with pitressin tannate

1984 • 17 citations

Discovery and Therapeutic Utility of Vasopressin Antagonists in Rats

1986 • 16 citations

Cyclooxygenase inhibition unmasks the full antidiuretic agonist activity of the vasopressin antagonist, SK&F 101926, in dogs.

1989 • 15 citations

[4-Phenylalanine]oxytocin, an inhibitor of the antidiuretic effect of 8-arginine-vasopressin

1975 • 14 citations

Further in vivo evidence for antagonist-to-antidiuretic action of arginine vasopressin

1983 • 14 citations

Evaluation of the pharmacologic properties of a vasopressin antagonist in Brattleboro rats.

1988 • 11 citations

ChemInform Abstract: POTENT AND SELECTIVE ANTAGONISTS OF THE ANTIDIURETIC RESPONSES TO ARGININE‐VASOPRESSIN BASED ON MODIFICATIONS OF (1‐(β‐MERCAPTO‐β,β‐PENTAMETHYLENEPROPIONIC ACID), 2‐D‐ISOLEUCINE, 4‐VALINE)ARGININE‐VASOPRESSIN AT POSITION 4

1984 • 7 citations