Review: Pathogenesis of Type 2 Diabetes Mellitus: An Interpretation of Current Data

Cortisol-Induced Insulin Resistance in Man: Impaired Suppression of Glucose Production and Stimulation of Glucose Utilization due to a Postreceptor Defect of Insulin Action*

1982 • 685 citations

Mechanisms of insulin resistance in human obesity: evidence for receptor and postreceptor defects.

1980 • 665 citations

Receptor and postreceptor defects contribute to the insulin resistance in noninsulin-dependent diabetes mellitus.

1981 • 628 citations

Glucose Intolerance and Aging: Evidence for Tissue Insensitivity to Insulin

1979 • 594 citations

Relationships Between Fasting Plasma Glucose Levels and Insulin Secretion During Intravenous Glucose Tolerance Tests

1976 • 493 citations

The Effect of Insulin Treatment on Insulin Secretion and Insulin Action in Type II Diabetes Mellitus

1985 • 464 citations

Effects of Growth Hormone on Insulin Action in Man: Mechanisms of Insulin Resistance, Impaired Suppression of Glucose Production, and Impaired Stimulation of Glucose Utilization

1982 • 434 citations

Relationships between insulin secretion, insulin action, and fasting plasma glucose concentration in nondiabetic and noninsulin-dependent diabetic subjects.

1984 • 407 citations

Characterization of the insulin resistance of aging.

1983 • 395 citations

Nonketotic diabetes mellitus: Insulin deficiency or insulin resistance?

1976 • 361 citations

Lilly Lecture 1980: Insulin Resistance and Insulin Action: An In Vitro and In Vivo Perspective

1981 • 317 citations

Insulin Treatment Reverses the Insulin Resistance of Type II Diabetes Mellitus

1982 • 219 citations

Arginine-stimulated acute phase of insulin and glucagon secretion in diabetic subjects.

1976 • 208 citations

Insulin Binding in Diabetes: Relationships with Plasma Insulin Levels and Insulin Sensitivity

1977 • 202 citations

Insulin Therapy in Obese, Non-insulin-dependent Diabetes Induces Improvements in Insulin Action and Secretion that Are Maintained for Two Weeks After Insulin Withdrawal

1984 • 189 citations

Insulin Sensitivity and Insulin Binding to Monocytes in Maturity-Onset Diabetes

1979 • 189 citations

A role for alpha-adrenergic receptors in abnormal insulin secretion in diabetes mellitus.

1976 • 178 citations

Type I Diabetes Mellitus in Monozygotic Twins: Chronic Progressive Beta Cell Dysfunction

1983 • 169 citations

The Glucose Receptor A DEFECTIVE MECHANISM IN DIABETES MELLITUS DISTINCT FROM THE BETA ADRENERGIC RECEPTOR

1973 • 166 citations

Mechanism of improvement in glucose metabolism after chronic glyburide therapy

1984 • 164 citations

Potentiation of Insulin Secretory Responses by Plasma Glucose Levels in Man: Evidence That Hyperglycemia in Diabetes Compensates for Impaired Glucose Potentiation*

1979 • 151 citations

The defective glucose sensitivity of the B cell in non insulin dependent diabetes. Improvement after twenty hours of normoglycaemia

1982 • 145 citations

Improvement of Insulin Secretion but Not Insulin Resistance after Short Term Control of Plasma Glucose in Obese Type II Diabetics*

1982 • 114 citations

Continuous Subcutaneous Insulin Infusion Therapy Decreases Insulin Resistance in Type 1 Diabetes*

1984 • 114 citations

Hyperinsulinemia and Hypoinsulinemia: Insulin Responses to Oral Carbohydrate Over a Wide Spectrum of Glucose Tolerance

1975 • 96 citations

Insulin Sensitivity in Newly Diagnosed Type 1 Diabetics after Ketoacidosis and after Three Months of Insulin Therapy*

1984 • 95 citations

Insulin-Mediated Glucose Disposal in Type I Diabetes: Evidence for Insulin Resistance

1983 • 92 citations

Reversal of insulin resistance in type I diabetes after treatment with continuous subcutaneous insulin infusion.

1983 • 83 citations

The Pathogenic Role of an Insulin-receptor Defect in Diabetes Mellitus of the Obese

1978 • 80 citations

Insulin Binding and Responsiveness in Fat Cells from Patients with Reduced Glucose Tolerance and Type II Diabetes

1983 • 73 citations

Clinical Significance of Altered Insulin Sensitivity in Diabetes Mellitus Assessed by Glucose, Insulin, and Somatostatin Infusion

1981 • 69 citations

Postreceptor Defects Causing Insulin Resistance in Normoinsulinemic Non-insulin-dependent Diabetes Mellitus

1982 • 67 citations

Prolonged sulfonylurea administration decreases insulin resistance and increases insulin secretion in non-insulin-dependent diabetes mellitus: evidence for improved insulin action at a postreceptor site in hepatic as well as extrahepatic tissues.

1984 • 60 citations

DIABETES MELLITUS-DIAGNOSIS AND TREATMENT

1968 • 58 citations

Differential effects of insulin therapy on hepatic and peripheral insulin sensitivity in Type 2 (non-insulin-dependent) diabetes

1982 • 57 citations

Lack of in Vivo Insulin Resistance in Controlled Insulin-Dependent, Type I, Diabetic Patients*

1984 • 50 citations

Insulin Binding, Internalization, and Insulin Receptor Regulation in Fibroblasts from Type II, Non-insulin-dependent Diabetic Subjects

1981 • 48 citations

Improved In Vivo Insulin Effect During Continuous Subcutaneous Insulin Infusion in Patients with IDDM

1984 • 46 citations

Insulin Response to Glucagon: The Opposing Effects of Diabetes and Obesity

1969 • 43 citations

Impaired Insulin Secretion in Human Diabetes Mellitus: The Effect of Naloxone-Induced Opiate Receptor Blockade

1982 • 40 citations

On the Pathogenesis of Maturity-Onset Diabetes

1981 • 39 citations

Decreased insulin sensitivity due to a postreceptor defect as a consequence of ATP‐deficiency in fat cells

1981 • 29 citations

Does day-long absolute hypoinsulinemia characterize the patient with non-insulin-dependent diabetes mellitus?

1983 • 29 citations

Augmented Insulin Responses to Glucose after Secretin Priming in Diabetic Subjects*

1979 • 18 citations

Reversal of Insulin Resistance in Type 1 Diabetes following Initiation of Insulin Treatment

1986 • 16 citations

Abnormal coupling of insulin receptor binding in noninsulin-dependent diabetes

1984 • 16 citations

Pathogenesis of impaired glucose tolerance and type II diabetes mellitus--current status.

1985 • 15 citations

Hyperglycemia and β-Cell Adaptation During Prolonged Somatostatin Infusion with Glucagon Replacement in Man

1983 • 14 citations

Insulin Binding and Insulin Action in Fibroblasts from Patients with Maturity-onset Diabetes of the Young

1981 • 13 citations

Impaired insulin secretion in human diabetes mellitus. I. The effect of alpha-adrenergic inhibition

1982 • 10 citations

Plasma insulin and C-peptide in relation to glucose intolerance in middle-aged men

1982 • 7 citations

Insulin binding to erythrocytes in diabetic patients.

1981 • 7 citations

Role of Insulin Receptors in Obesity-Related Diabetes

1982 • 3 citations

Determination by factor analysis of the relative importance of impaired insulin secretion and insulin resistance in the type ii diabetes

1984 • 1 citations

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