Construction of a model for the three-dimensional structure of human renal renin.

<scp>CHARMM</scp>: A program for macromolecular energy, minimization, and dynamics calculations

1983 • 14,615 citations

The interpretation of protein structures: Estimation of static accessibility

1971 • 5,771 citations

On the size of the active site in proteases. I. Papain

1967 • 5,150 citations

A graphics model building and refinement system for macromolecules

1978 • 1,858 citations

Energy parameters in polypeptides. VII. Geometric parameters, partial atomic charges, nonbonded interactions, hydrogen bond interactions, and intrinsic torsional potentials for the naturally occurring amino acids

1975 • 1,532 citations

Principles of protein–protein recognition

1975 • 1,028 citations

THE PREPARATION AND FUNCTION OF THE HYPERTENSIN-CONVERTING ENZYME

1956 • 994 citations

Structural invariants in protein folding

1975 • 865 citations

A possible three-dimensional structure of bovine α-lactalbumin based on that of hen's egg-white lysozyme

1969 • 517 citations

Structure and refinement of penicillopepsin at 1.8 Å resolution

1983 • 405 citations

Cloning and sequence analysis of cDNA for human renin precursor.

1983 • 266 citations

Potent new inhibitors of human renin

1982 • 239 citations

Computation of structures of homologous proteins. .alpha.-Lactalbumin from lysozyme

1974 • 230 citations

Isolation and characterization of renin-like enzymes from mouse submaxillary glands

1972 • 215 citations

Three-dimensional structure, specificity and catalytic mechanism of renin

1983 • 207 citations

Complete amino acid sequence and maturation of the mouse submaxillary gland renin precursor

1982 • 190 citations

Three-dimensional structure of the complex of the Rhizopus chinensis carboxyl proteinase and pepstatin at 2.5 .ANG. resolution

1982 • 185 citations

Penicillopepsin from Penicillium janthinellum crystal structure at 2.8 Å and sequence homology with porcine pepsin

1977 • 168 citations

EFFECT OF PEPSTATIN ON ACID PROTEASES

1971 • 160 citations

The Mechanism of the Catalytic Action of Pepsin and Related Acid Proteinases

1976 • 159 citations

Conformational flexibility in the active sites of aspartyl proteinases revealed by a pepstatin fragment binding to penicillopepsin.

1982 • 148 citations

Isolation of pure and stable renin from hog kidney

1975 • 127 citations

Human renal renin. Complete purification and characterization.

1980 • 125 citations

Homology among acid proteases: comparison of crystal structures at 3A resolution of acid proteases from Rhizopus chinensis and Endothia parasitica.

1977 • 119 citations

Mechanism of acid protease catalysis based on the crystal structure of penicillopepsin

1977 • 115 citations

Amino acid sequence of mouse submaxillary gland renin.

1982 • 103 citations

Pure human renin. Identification and characterization and of two major molecular weight forms.

1981 • 94 citations

Model for haptoglobin heavy chain based upon structural homology.

1980 • 92 citations

Complete purification of dog renal renin

1979 • 79 citations

Molecular cloning and nucleotide sequence of a human renin cDNA fragment

1983 • 79 citations

Membrane-bound Angiotensin-converting Enzyme from Rat Lung

1974 • 72 citations

Competitive inhibitors of renin. Inhibitors effective at physiological pH

1975 • 71 citations

Human angiotensinogen. Purification partial characterization, and a comparison with animal prohormones.

1977 • 56 citations

THE CHEMISTRY OF RENIN SUBSTRATE.

1964 • 41 citations

Biochemistry and kinetics of the renin-angiotensin system.

1967 • 39 citations

Antibodies as Specific Renin Inhibitors: Studies with Polyclonal and Monoclonal Antibodies and Fab Fragments

1983 • 33 citations

On the specificity of human renin. Studies with peptide inhibitors

1976 • 31 citations

Specific Chemical Modifications of Acid Proteases in the Presence and Absence of Pepstatin*

1973 • 26 citations

Amino acid sequence of penicillopepsin. IV. Myxobacter AL-1 protease II and Staphylococcus aureus protease fragments and homology with pig pepsin and chymosin

1976 • 22 citations

Structural aspects of thrombin specificity

1975 • 21 citations

Molecular structure: Computer cues to combat hypertension

1983 • 9 citations