Natural amino acid polymorphisms of the circumsporozoite protein of Plasmodium falciparum abrogate specific human CD4⁺ T cell responsiveness

General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids.

1985 • 1,650 citations

Structure of the Gene Encoding the Immunodominant Surface Antigen on the Sporozoite of the Human Malaria Parasite Plasmodium falciparum

1984 • 716 citations

γ Interferon, CD8+ T cells and antibodies required for immunity to malaria sporozoites

1987 • 699 citations

Molecular analysis of the association of HLA-B53 and resistance to severe malaria

1992 • 645 citations

Cloned cytotoxic T cells recognize an epitope in the circumsporozoite protein and protect against malaria

1989 • 505 citations

A hypothesis to relate the specificity of T lymphocytes and the activity of I region-specific Ir genes in macrophages and B lymphocytes.

1978 • 488 citations

Limiting Dilution Analysis of Cells in the Immune System

1979 • 384 citations

Structural characteristics of an antigen required for its interaction with Ia and recognition by T cells

1987 • 367 citations

Limiting Dilution Analysis of Cells in the Immune System

1980 • 325 citations

Inhibition of Development of Exoerythrocytic Forms of Malaria Parasites by γ-Interferon

1986 • 315 citations

Identification of the T-cell and Ia contact residues of a T-cell antigenic epitope

1987 • 297 citations

Opinion

1978 • 283 citations

Human T-cell recognition of the circumsporozoite protein of Plasmodium falciparum: immunodominant T-cell domains map to the polymorphic regions of the molecule.

1988 • 264 citations

Oral Salmonella typhimurium Vaccine Expressing Circumsporozoite Protein Protects Against Malaria

1988 • 250 citations

Peptide binding to HLA-DR1: a peptide with most residues substituted to alanine retains MHC binding.

1990 • 248 citations

Synthetic peptide vaccine confers protection against murine malaria.

1987 • 232 citations

CD8⁺ cytolytic T cell clones derived against the Plasmodium yoelii circumsporozoite protein protect against malaria

1991 • 215 citations

Oral Salmonella: malaria circumsporozoite recombinants induce specific CD8+ cytotoxic T cells.

1990 • 207 citations

Cytotoxic T cells specific for the circumsporozoite protein of Plasmodium falciparum

1988 • 180 citations

Functional consequences of engagement of the T cell receptor by low affinity ligands.

1993 • 171 citations

Interferon-gamma inhibits the intrahepatocytic development of malaria parasites in vitro.

1987 • 157 citations

Human cytotoxic T lymphocytes against the Plasmodium falciparum circumsporozoite protein.

1991 • 147 citations

Circumsporozoite protein genes of malaria parasites (Plasmodium spp.): evidence for positive selection on immunogenic regions.

1991 • 126 citations

The importance of dominant negative effects of amino acid side chain substitution in peptide-MHC molecule interactions and T cell recognition.

1993 • 117 citations

Effector functions of circumsporozoite peptide-primed CD4+ T cell clones against Plasmodium yoelii liver stages.

1993 • 113 citations

Wild isolates of Plasmodium falciparum show extensive polymorphism in T cell epitopes of the circumsporozoite protein

1989 • 112 citations

Sequence variation in putative functional domains of the circumsporozoite protein of Plasmodium falciparum. Implications for vaccine development.

1987 • 111 citations

A T cell clone directed at the circumsporozoite protein which protects mice against both Plasmodium yoelii and Plasmodium berghei.

1992 • 109 citations

Immunity to sporozoite-induced malaria infeciton in mice. I. The effect of immunization of T and B cell-deficient mice.

1977 • 109 citations

Structural requirements for class I MHC molecule-mediated antigen presentation and cytotoxic T cell recognition of an immunodominant determinant of the human immunodeficiency virus envelope protein.

1989 • 102 citations

The T Cell Response to the Malaria Circumsporozoite Protein: An Immunological Approach to Vaccine Development

1988 • 99 citations

In situ distribution of major histocompatibility complex products and viral antigens in chronic hepatitis B virus infection: Evidence that HBc-containing hepatocytes may express HLA-DR antigens

1986 • 85 citations

Recombinant human gamma interferon inhibits simian malaria

1986 • 83 citations

Strain variation in the circumsporozoite protein gene of Plasmodium falciparum

1987 • 80 citations

Cytotoxic CD4+ T cells from a sporozoite-immunized volunteer recognize the Plasmodium falciparum CS protein

1991 • 79 citations

Competitor analogs for defined T cell antigens: Peptides incorporating a putative binding motif and polyproline or polyglycine spacers

1990 • 79 citations

Structural analysis of a peptide-HLA class II complex: identification of critical interactions for its formation and recognition by T cell receptor

1989 • 78 citations

Immunity to Sporozoite-Induced Malaria Infection in Mice

1977 • 76 citations

CD4+ T cell clones obtained from Plasmodium falciparum sporozoite-immunized volunteers recognize polymorphic sequences of the circumsporozoite protein.

1993 • 75 citations

Ubiquity of the repetitive epitope of the CS protein in different isolates of human malaria parasites.

1985 • 74 citations

Structure of the circumsporozoite protein gene in 18 strains of Plasmodium falciparum

1985 • 71 citations

Naturally acquired CD8+ cytotoxic T lymphocytes against the Plasmodium falciparum circumsporozoite protein.

1992 • 68 citations

Functionally distinct agretopic and epitopic sites. Analysis of the dominant T cell determinant of moth and pigeon cytochromes c with the use of synthetic peptide antigens.

1987 • 65 citations

Human T cells recognize polymorphic and non-polymorphic regions of the Plasmodium falciparum circumsporozoite protein.

1988 • 56 citations

Geographically restricted heterogeneity of the Plasmodium falciparum circumsporozoite protein: relevance for vaccine development

1992 • 56 citations

Analysis of peptide binding patterns in different major histocompatibility complex/T cell receptor complexes using pigeon cytochrome c-specific T cell hybridomas. Evidence that a single peptide binds major histocompatibility complex in different conformations.

1989 • 56 citations

Location of human cytotoxic T cell epitopes within a polymorphic domain of the Plasmodium falciparum circumsporozoite protein

1991 • 55 citations

Inhibitory activity of IL‐6 on malaria hepatic stages

1991 • 54 citations

Human T clones reactive to the sexual stages of Plasmodium falciparum malaria. High frequency of gamete-reactive T cells in peripheral blood from nonexposed donors.

1987 • 54 citations

High frequency of malaria‐specific T cells in non‐exposed humans

1992 • 53 citations

Analysis of peptide residues interacting with MHC molecule or T cell receptor. Can a peptide bind in more than one way to the same MHC molecule?

1990 • 51 citations

Major population differences in T cell response to a malaria sporozite vaccine candidate

1990 • 48 citations

Circumsporozoite gene of a Plasmodium falciparum strain from Thailand

1987 • 45 citations

Malarial immunity: current trends and prospects

1987 • 45 citations

Lack of cross-reactivity between variant T cell determinants from malaria circumsporozoite protein.

1988 • 42 citations

Human T lymphocyte clones specific for malaria (Plasmodium falciparum) antigens.

1985 • 38 citations

Plasmodium berghei sporozoites are mitogenic for murine T cells, induce interferon, and activate natural killer cells.

1984 • 38 citations

Plasmodium falciparum: Restricted polymorphism of T cell epitopes of the circumsporozoite protein in Brazil

1990 • 34 citations

Reconstruction of the immunogenic peptide RNase(43-56) by identification and transfer of the critical residues into an unrelated peptide backbone.

1989 • 29 citations

Host-parasite interactions and immunity to irradiated sporozoites

1990 • 28 citations

Modification of the T cell responsiveness to synthetic peptides by substituting amino acids on agretopes

1990 • 27 citations

Role of single amino acids in the recognition of a T cell epitope.

1991 • 26 citations

Cloning and characterization of an abundant Plasmodium knowlesi antigen which cross reacts with Gambian sera

1987 • 4 citations