A prospective study on the natural history of multiple sclerosis: clues to the conduct and interpretation of clinical trials

PROBLEMS OF EXPERIMENTAL TRIALS OF THERAPY IN MULTIPLE SCLEROSIS: REPORT BY THE PANEL ON THE EVALUATION OF EXPERIMENTAL TRIALS OF THERAPY IN MULTIPLE SCLEROSIS

1965 • 1,402 citations

THE NATURAL HISTORY OF MULTIPLE SCLEROSIS: A GEOGRAPHICALLY BASED STUDY

1989 • 1,387 citations

McAlpine's Multiple Sclerosis

2006 • 768 citations

MRI in the diagnosis of MS

1988 • 650 citations

THE NATURAL HISTORY OF MULTIPLE SCLEROSIS: A GEOGRAPHICALLY BASED STUDY

1989 • 597 citations

Prognostic factors in a multiple sclerosis incidence cohort with twenty-five years of follow-up

1993 • 570 citations

COURSE AND PROGNOSIS OF MULTIPLE SCLEROSIS ASSESSED BY THE COMPUTERIZED DATA PROCESSING OF 349 PATIENTS

1980 • 496 citations

THE NATURAL HISTORY OF MULTIPLE SCLEROSIS: A GEOGRAPHICALLY BASED STUDY

1991 • 409 citations

The significance of brain magnetic resonance imaging abnormalities at presentation with clinically isolated syndromes suggestive of multiple sclerosis

1993 • 359 citations

Interrater variability with the Expanded Disability Status Scale (EDSS) and Functional Systems (FS) in a multiple sclerosis clinical trial

1990 • 302 citations

Correlations between changes in disability and T ₂ ‐weighted brain MRI activity in multiple sclerosis

1995 • 297 citations

Clinical worsening in multiple sclerosis is associated with increased frequency and area of gadopentetate dimeglumine–enhancing magnetic resonance imaging lesions

1993 • 237 citations

McAlpine's Multiple Sclerosis

1991 • 211 citations

Inter‐ and intrarater scoring agreement using grades 1.0 to 3.5 of the Kurtzke Expanded Disability Status Scale (EDSS)

1992 • 208 citations

Optic neuritis

1998 • 194 citations

THE BENIGN FORM OF MULTIPLE SCLEROSIS. A STUDY BASED ON 241 CASES SEEN WITHIN THREE YEARS OF ONSET AND FOLLOWED UP UNTIL THE TENTH YEAR OR MORE OF THE DISEASE

1961 • 181 citations

THE NATURAL HISTORY OF MULTIPLE SCLEROSIS: A GEOGRAPHICALLY BASED STUDY

1991 • 172 citations

Magnetic resonance imaging of the head in the diagnosis of multiple sclerosis: A prospective 2‐year follow‐up with comparison of clinical evaluation, evoked potentials, oligoclonal banding, and CT

1991 • 161 citations

Longitudinal MRI in multiple sclerosis

1994 • 139 citations

Interrater Reliability in Assessing Functional Systems and Disability on the Kurtzke Scale in Multiple Sclerosis

1988 • 139 citations

Long‐term follow‐up of acute partial transverse myelopathy

1992 • 129 citations

An Assessment of Disability Rating Scales Used in Multiple Sclerosis

1991 • 95 citations

Exacerbation Rates and Adherence to Disease Type in a Prospectively Followed-up Population With Multiple Sclerosis

1989 • 89 citations

The predictive value of intrathecal immunoglobulin synthesis and magnetic resonance imaging in acute isolated syndromes for subsequent development of multiple sclerosis

1991 • 88 citations

A prospective study on the predictive value of CSF oligoclonal bands and MRI in acute isolated neurological syndromes for subsequent progression to multiple sclerosis.

1996 • 78 citations

The predictive value of CSF oligoclonal banding for MS 5 years after optic neuritis

1998 • 71 citations

Clinical and magnetic resonance imaging in optic neuritis

1991 • 65 citations

Meta-analysis of the placebo-treated groups in clinical trials of progressive MS

1996 • 64 citations

Correlation of magnetic resonance imaging and CSF findings in patients with acute monosymptomatic optic neuritis

1992 • 46 citations

Clinical parameters and intrathecal IgG synthesis as prognostic features in multiple sclerosis. Part I

1983 • 46 citations

Inter and intra-observer reliability in Kurtzke scoring systems in multiple sclerosis.

1987 • 11 citations

Clinical and CSF Findings in Multiple Sclerosis Patients with or without IgG Oligoclonal Bands at Isoelectric Focusing Examination of CSF and Serum Proteins

1983 • 9 citations

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